A5060518014- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Bioactive Natural Diterpenoids Research
- Nitric Oxide and Endothelin Effects
- Inflammatory mediators and NSAID effects
Universidade Estadual Paulista (Unesp)
2016-2022
Eugenia spp. are used in popular medicine the treatment of pain, diabetes, intestinal disorders and cough. The aim work is to evaluate, ex vivo vivo, anti-inflammatory activity hydroethanolic extracts leaves aurata (EA) punicifolia HBK (EP) upon neutrophils.Ex isolated human neutrophils were sensitized by (0.1-1000 μg/mL) stimulated PMA. In these conditions, different neutrophil activities related inflammatory process measured: adhesion, degranulation NET release. Neutrophil viability tumor...
Neutrophil extracellular traps (NETs) were first reported as a microbicidal strategy for activated neutrophils. Through an immunologic response against several stimuli, neutrophils release their DNA together with proteins from granules, nucleus, and cytoplasm (e.g., elastase myeloperoxidase). To date, NETs have been implicated in tissue damage during intense inflammatory processes, mainly when is dependent on oxygen radical generation. Flavonoids are antioxidant anti-inflammatory agents; of...