M. F. Costa

ORCID: 0000-0003-1237-0538
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About
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Research Areas
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Phytochemistry and Biological Activities
  • Microbial infections and disease research
  • Bacteriophages and microbial interactions
  • Fungal Biology and Applications
  • Polysaccharides and Plant Cell Walls
  • Aquaculture disease management and microbiota
  • Nitric Oxide and Endothelin Effects
  • Seed Germination and Physiology
  • Pharmacological Effects of Natural Compounds
  • Bioactive Natural Diterpenoids Research
  • Blood groups and transfusion
  • Respiratory viral infections research
  • Plant tissue culture and regeneration
  • Essential Oils and Antimicrobial Activity
  • Biological and pharmacological studies of plants
  • Ginseng Biological Effects and Applications
  • Academic Research in Diverse Fields
  • Inflammatory mediators and NSAID effects
  • Immune cells in cancer
  • Seaweed-derived Bioactive Compounds
  • Facial Trauma and Fracture Management

Universidade Estadual Paulista (Unesp)
2014-2025

Universidade de São Paulo
2016

American Society of Safety Professionals
2016

Eugenia spp. are used in popular medicine the treatment of pain, diabetes, intestinal disorders and cough. The aim work is to evaluate, ex vivo vivo, anti-inflammatory activity hydroethanolic extracts leaves aurata (EA) punicifolia HBK (EP) upon neutrophils.Ex isolated human neutrophils were sensitized by (0.1-1000 μg/mL) stimulated PMA. In these conditions, different neutrophil activities related inflammatory process measured: adhesion, degranulation NET release. Neutrophil viability tumor...

10.1186/s12906-016-1375-7 article EN cc-by BMC Complementary and Alternative Medicine 2016-10-22

Strategies focusing on natural compounds and nanotechnology have been explored to overcome the limitations of conventional therapies in managing Candida infections. In this context, metal nanoparticles, both non-functionalised combined with gallic acid, may offer a promising alternative. This study investigated effects gold nanoparticles (AuNp) associated acid (AuNpGA) against planktonic cells biofilms Nakaseomyces glabratus, Pichia kudriavzevii, parapsilosis, tropicalis. Both AuNp AuNpGA...

10.1080/08927014.2025.2504026 article EN Biofouling 2025-05-19

Neutrophil extracellular traps (NETs) were first reported as a microbicidal strategy for activated neutrophils. Through an immunologic response against several stimuli, neutrophils release their DNA together with proteins from granules, nucleus, and cytoplasm (e.g., elastase myeloperoxidase). To date, NETs have been implicated in tissue damage during intense inflammatory processes, mainly when is dependent on oxygen radical generation. Flavonoids are antioxidant anti-inflammatory agents; of...

10.1590/1519-6984.252936 article EN cc-by Brazilian Journal of Biology 2022-04-15

The main phenolic constituents of <italic>S. obovatum</italic> leaf extracts, analyzed by FT-ICR MS, were correlated with their antioxidant and <italic>in vitro</italic> antiproliferative activities.

10.1039/c6ay01272h article EN Analytical Methods 2016-01-01

Abstract Contamination of primary and cell cultures by mycoplasmas is one the main economic biological pitfalls in basic research, diagnosis manufacture biotechnological products. It a common issue which may be difficult to conduct surveillance on. Mycoplasma presence affect several physiological parameters cell, besides being considered an important source inaccurate and/or non-reproducible scientific results. Each type presents characteristical symptoms, mainly morphological, that indicate...

10.1590/1519-6984.215721 article EN cc-by Brazilian Journal of Biology 2020-04-22

Human Respiratory Syncytial Virus (hRSV) infection results in death and hospitalization of thousands people worldwide each year. Unfortunately, there are no vaccines or specific treatments for hRSV infections. Screening hundreds even promising molecules is a challenge science. We integrated biological, structural, physicochemical properties to train apply the concept artificial intelligence (AI) able predict flavonoids with potential anti-hRSV activity. During training simulation steps, AI...

10.1590/1519-6984.270776 article EN PubMed 2023-01-01
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