A5076649716- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Nanoparticles: synthesis and applications
- Photodynamic Therapy Research Studies
- Studies on Chitinases and Chitosanases
- Complementary and Alternative Medicine Studies
- Herbal Medicine Research Studies
- Click Chemistry and Applications
- Oral microbiology and periodontitis research
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Toxin Mechanisms and Immunotoxins
- Plant-Microbe Interactions and Immunity
- Legionella and Acanthamoeba research
- Botanical Research and Applications
- Gut microbiota and health
- Graphene and Nanomaterials Applications
- Planarian Biology and Electrostimulation
- Diverse Scientific Research Studies
- Skin Protection and Aging
- Medicinal Plant Extracts Effects
- Phytochemistry Medicinal Plant Applications
Universidade Estadual Paulista (Unesp)
2022-2025
Universidade Federal de Minas Gerais
2018-2024
Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
2023
Universidade do Vale do Paraíba
2023
Brf (Brazil)
2023
Vanillin is the main component of natural vanilla extract and responsible for its flavoring properties. Besides well-known applications as an additive in food cosmetics, it has also been reported that vanillin can inhibit fungi clinical interest, such Candida spp., Cryptococcus Aspergillus well dermatophytes. Thus, present work approaches synthesis a series derivatives with 1,2,3-triazole fragments evaluation their antifungal activities against albicans, glabrata, parapsilosis, tropicalis,...
The development of engineered nanomaterials has been considered a promising strategy to control oral infections. In this study, silver-embedded carbon nitrides (Ag@g-CN) were synthesized and tested against Candida albicans, investigating their antifungal action biocompatibility in animal cells. Ag@g-CN was by simple one-pot thermal polymerization technique characterized various analytical techniques. X-ray diffraction (XRD) analysis revealed slight alterations the crystal structure g-CN upon...
Candida albicans is an opportunistic yeast capable of causing a wide range mucosal, cutaneous, and systemic infections. However, therapeutic strategies are limited to few antifungal agents. Inorganic nanoparticles have been investigated as carrier systems for antifungals potential new treatments. In this study, we focused on the activity gold nanorods, specific rod-shaped nanoparticle, produced by green synthesis using resveratrol metal-reducing agent. The method resulted in stable control...
Strategies focusing on natural compounds and nanotechnology have been explored to overcome the limitations of conventional therapies in managing Candida infections. In this context, metal nanoparticles, both non-functionalised combined with gallic acid, may offer a promising alternative. This study investigated effects gold nanoparticles (AuNp) associated acid (AuNpGA) against planktonic cells biofilms Nakaseomyces glabratus, Pichia kudriavzevii, parapsilosis, tropicalis. Both AuNp AuNpGA...
Abstract Galleria mellonella larvae are widely used for microbiological and toxicological studies due to their reproducibility of results, low costs, ease handling. Despite these advantages, the maintenance homogeneous colonies G. in laboratory rearing can face many challenges. We proposed a standardized protocol incubation eggs, aiming enhance larval development provide consistent accessible experimental model research. One Basic Protocol two Alternate Protocols were established simulate...
Introduction Galleria mellonella is widely used as an in vivo model microbiological and toxicological studies due to its reproducibility, low cost, ease of handling. However, maintaining homogeneous laboratory colonies presents challenges. This study evaluated whether different incubation methods influence the larval immune response against Staphylococcus aureus, Candida albicans , Escherichia coli . Methods Four experimental groups were established: (1) Traditional group (TG), eggs stored...
Candida albicans can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs delivery systems. In this study, caffeic acid phenethyl ester (CAPE) gellan gum (GG) were studied as an antifungal agent carrier system, respectively. First, we observed that different GG formulations (0.6 1.0% wt/vol) able incorporate release CAPE, reaching a...
This study investigated the antimicrobial activity of surface pre-reacted glass ionomer eluate (S-PRG) against oral microcosm biofilms collected from cavity patients. Dental biofilm samples were three volunteers to form in vitro. Initially, screening tests carried out determine treatment conditions with S-PRG eluate. The effects a daily for 5 min using different patients was then evaluated. For this, formed on tooth enamel specimens 120 h. Biofilms treated 100% per day days showed reduction...
Onychomycosis is a nail infection caused by Trichophyton interdigitale and other fungi, which can be treated with topical amorolfine (AMR) ciclopirox olamine (CPX). Although these drugs are widely used, little known about the role of reactive oxygen (ROS) nitrogen (RNS) in their mechanism action. To better understand effects AMR CPX dermatophytes, we evaluated whether they act through production ROS peroxynitrite (PRN). We tested set strains, all susceptible to CPX, antifungals significantly...
Cryptococcus gattii (Cg) is one of the agents cryptococcosis, a severe systemic mycosis with higher prevalence in men than women, but influence female sex hormone, 17-β-estradiol (E2), on cryptococcosis remains unclear. Our study shows that mice presented delayed mortality, increased neutrophil recruitment bronchoalveolar lavage fluid, and reduced fungal load after 24 hr infection compared to male ovariectomised (OVX). E2 replacement restored OVX survival. Female macrophages have more...
Cryptococcosis is an invasive mycosis caused by Cryptococcus spp. that affects the lungs and central nervous system (CNS). Due to severity of disease, it may occur concomitantly with other pathogens, as a coinfection. Pseudomonas aeruginosa (Pa), opportunistic pathogen, can also cause pneumonia. In this work, we studied interaction C. gattii (Cg) Pa, both in vitro vivo. Pa reduced growth Cg secretion inhibitory molecules vitro. Macrophages previously stimulated presented increased fungicidal...
Abstract Cryptococcus gattii, an environmental yeast isolated from plants, is one of the agents cryptococcosis. Here, we aimed to develop a plant model study C. gattii–plant interaction, since it unclear how affects and yeast. We tested three inoculation methods (scarification, infiltration, abrasion) in species: Arabidopsis thaliana, Nicotiana tabacum, N. benthamiana. gattii was able grow all models, with peak cell burden after 7 days, without any pathological effects. Furthermore, fungal...
Abstract Dermatophytosis is the most common human skin infection worldwide caused by dermatophytes, such as Trichophyton interdigitale and rubrum. Itraconazole (ITZ) one of main antifungals used to treat these infections. However, especially for onychomycosis, treatment requires long-term regimens, increasing possibility drug resistance. We evaluated effects ITZ in physiology, virulence, interaction T. with phagocytes mice cutaneous infection. In a screening test, fungal growth presence led...
Abstract Cryptococcosis is a life-threatening fungal infection, and its current treatment toxic subject to resistance. Drug repurposing represents an interesting approach find drugs reduce the toxicity of antifungals. In this study, we evaluated combination N-acetylcysteine (NAC) with amphotericin B (AMB) for cryptococcosis. We examined effects NAC on morphophysiology macrophage fungicidal activity 3 24 hours post inoculation. The therapeutic AMB were investigated in murine model daily...
The trypanosomatids, such as the protozoan Leishmania spp., have a demand by ergosterol, which is not present in membrane from mammal cells. suppression of synthesis ergosterol would be new target compounds with leishmanicidal activity, and bistriazole has shown trypanocidal activity this mechanism. incidence fungal infections increased at an alarming rate over last decades. This related both to growing population immune-compromised individuals emergence strains that are resistant available...
Abstract Pantoea ananatis is the causal agent of maize white spot, a foliar disease responsible for significant yield reduction worldwide, especially in Brazil. In general, diseases control involves adoption resistant genotypes and pesticides application. However, use agrochemicals can significantly cause increase production costs, damage to human health negative environmental impacts. this sense, biological agents has been considered among most promising eco-friendly technologies...
Cryptococcosis is a systemic mycosis that causes pneumonia and meningoencephalitis. Strongyloidiasis chronic gastrointestinal infection caused by parasites of the genus Strongyloides. strongyloidiasis affect lungs are more prevalent in same world regions, i.e., Africa tropical countries such as Brazil. It undeniable those coincidences may lead to occurrence coinfections. However, there no studies focused on interaction between Cryptococcus spp. Strongyloides In this work, we aimed...
Abstract Microorganisms that cause pneumonia and translocate to the central nervous system (CNS) are responsible for high mortality worldwide. The fungus Cryptococcus gattii (Cg) bacteria Streptococcus pneumoniae (Sp) target same infection organs. This study aimed investigate consequences of secondary Sp during murine cryptococcosis. Mice infected with after Cg showed significantly increased lethality a drop in scores motor behaviour, neuropsychiatric status autonomous function. Previous...