Abstract Background In the present study, we aim to assess a novel silk‐fibroin (SF) chitosan (CH) film treat oral mucosa wounds. Methods The SF/CH films, sterilized with 130 Gy in gamma cell, were subjected tests for thickness, water vapor permeability, tensile strength, elongation, and swelling as well scanning electron microscopy. Additionally, vitro cytotoxicity genotoxicity evaluated using human epidermal keratinocytes, foreskin fibroblasts, gingival fibroblasts. A pilot clinical trial...

Green propolis may represent a promising therapeutic alternative against dental anaerobic pathogens because of its antimicrobial action. This study aimed to evaluate the and antibiofilm actions Brazilian green aqueous extract (BGP-AqExt) bacteria. The minimum inhibitory concentration (MIC) microbicide (MMC) were determined standard strains (ATCC)

(1) Background: In hospitals, medical and dental clinics, antiseptics or disinfectants play an essential role in the control of nosocomial infections. This study aimed to evaluate R. officinalis P. paniculata glycolic extracts regarding: (I) their antimicrobial action on planktonic biofilm (monotypic cutaneous model—S. aureus, S. epidermidis C. acnes); (II) cytotoxicity human keratinocytes (HaCaT). (2) Methods: Minimum inhibitory concentration (MIC) minimum bactericidal (MBC) were performed...

Over the past few years, several tridimensional synthetic bone grafts, known as scaffolds, are being developed to overcome autologous grafts limitations. Among materials used on production of 45S5 bioglass stands out due its capacity bonding hard and soft tissues. Silver nanoparticles well-known for their antimicrobial properties incorporation scaffold may promote response, avoiding microorganism proliferation surface. This study proposes a simple way coat bioglass-based scaffolds with...

This study evaluates the antimicrobial activity of glycolic extract G. sylvestre against anaerobic pathogens, along with its cytotoxicity, genotoxicity, anti-inflammatory activity, antioxidant effects, and phytochemical composition. Phytochemical analysis was conducted using high-performance liquid chromatography chromatography-mass spectrometry, while effect assessed through a DPPH assay. Antimicrobial action tested on planktonic cultures biofilms Porphyromonas gingivalis, endodontalis,...

Periodontal disease (PD) is a significant global health concern, affecting approximately 19% of the world’s population. It one most prevalent diseases today, causing substantial socio-economic impacts and diminished quality life. Recent research has also revealed potential link between PD Alzheimer’s disease. This study investigated antimicrobial effects Juglans regia Pfaffia paniculata extracts against P. endodontalis gingivalis , bacteria that cause are related to risk. The assessed impact...

Background/Objectives: Colorectal neoplasms rank as the third most prevalent cancer globally and stand second leading cause of cancer-related mortality. Its etiology is multifaceted, pointing to role microorganisms within human microbiota in its development. Notably, high prevalence oral pathogens like Fusobacterium nucleatum Parvimonas micra implicated inducing gut dysbiosis stimulating proliferation metastasis cells. Therefore, this study aimed evaluate vitro biological effects extracts...

This study evaluated the action of Pfaffia paniculata K., Juglans regia L., and Rosmarius officinalis L. extracts against planktonic form biofilm Klebsiella pneumoniae (ATCC 4352). Minimum inhibitory concentration (MIC) minimum microbicidal (MMC) values were determined for each extract by microdilution broth method, according to Clinical Laboratory Standards Institute. Next, antimicrobial activity on was analyzed. For this, standardized suspension at 10 7 UFC/mL K. distributed into 96-well...

This study aimed to evaluate sodium hypochlorite (NaOCl), limewater (LW), and Polymyxin B (PMB) as irrigants over MMP-3, MMP-8 MMP-9. Thirty-three patients with apical periodontitis of single-rooted teeth were treated according three-experimental groups (n=11): group-1: 2.5% NaOCl was used irrigant; group-2: for the first two files LW: [0.14% Ca(OH)2] last files; group-3: PMB files. The association Ca(OH)2 CHX an intracanal medication in all groups. Four root canal samplings (S) collected:...

Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential glycolic extract Curcuma longa (C. longa); antifungal activity C. longa, curcumin, and photodynamic therapy (aPDT) with blue light-emitting diodes "LED" on albicans tropicalis vitro; toxicity curcumin Galleria mellonella model. In order confirm light absorption capacity extract, its was evaluated. The effect aPDT evaluated over...

This study aimed to evaluate the antimicrobial effect of four herbal plants glycolic extracts over mixed-species biofilm composed Candida albicans (C. albicans) and another pathogenic bacterium as alternative therapy be investigated. Four extract Pfaffia paniculata roots; Hamamelis virginiana leaf, Stryphnodendron barbatiman tree bark Gymnema sylvestre stem leaves were tested multi-species C. (ATCC 18804) Streptococcus mutans 35688), Staphylococcus aureus 6538), Enterococcus faecalis 4083)...

The accumulated dental biofilm can be a source of oral bacteria that are aspirated into the lower respiratory tract causing ventilator-associated pneumonia in hospitalized patients. aim this study was to evaluate synergistic antibiofilm action produced and phytochemically characterized extracts Cinnamomum verum Brazilian green propolis (BGP) hydroethanolic against multidrug-resistant clinical strains Acinetobacter baumannii Pseudomonas aeruginosa, addition their biocompatibility on human...

Abstract Calcium silicate-based cements have diverse applications in endodontics. This study aimed to evaluate the antibiofilm action, biocompatibility, morphological structure, chemical composition and radiopacity of Five Mineral Oxides (5MO), Trioxide Aggregate Repair High Plasticity (MTA HP), (MTA) cements. MTT analysis was used test action these against five anaerobic microorganisms, their biocompatibility with mouse macrophage (RAW 264.7) osteoblasts (MG-63) cultures. Their structure...

Candida albicans can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs delivery systems. In this study, caffeic acid phenethyl ester (CAPE) gellan gum (GG) were studied as an antifungal agent carrier system, respectively. First, we observed that different GG formulations (0.6 1.0% wt/vol) able incorporate release CAPE, reaching a...

The World Health Organization (WHO) has prioritized developing new drugs against specific bacteria and fungi, such as Enterobacteriaceae Candida spp. While Pfaffia paniculata is commonly called the “cure-everything”, its scientifically proven benefits are limited to anti-inflammatory antioxidant actions. Therefore, this study aims determine spectrum of antimicrobial activity assess cytotoxicity. Thus, broth microdilution test was conducted according CLSI M7-A9 M27-A3 reference methods. After...

Temporomandibular disorders (TMD) are a public health problem that affects around 12% of the global population. The treatment is based on analgesics, non-steroidal anti-inflammatory, corticosteroids, anticonvulsants, or arthrocentesis associated with hyaluronic acid-based viscosupplementation. However, use acid alone in viscosupplementation does not seem to be enough regulate intra-articular inflammatory process. So, we propose develop and evaluate physicochemical biological properties vitro...

This study is aimed at evaluating five mineral oxides (5MO), trioxide aggregate repair high plasticity (MTA HP), and (MTA) in relation to the antimicrobial action over

Propolis could represent an alternative therapeutic agent for targeting multidrug-resistant bacteria due to its antimicrobial potential. The effect of Brazilian green propolis (BGP) aqueous extract (AqExt) was evaluated on eight clinical strains Klebsiella pneumoniae and Pseudomonas aeruginosa, as well one reference strain each bacterial species. minimum bactericidal concentration (MBC) determined optimal concentrations were further in comparison with 0.12% chlorhexidine. natural chemically...