A5046993013- Parasites and Host Interactions
- Eosinophilic Esophagitis
- Parasitic infections in humans and animals
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Parasite Biology and Host Interactions
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
- Research on Leishmaniasis Studies
- Diet and metabolism studies
- Mosquito-borne diseases and control
- Malaria Research and Control
- Whipple's Disease and Interleukins
- Child Nutrition and Water Access
- Ginseng Biological Effects and Applications
- Wound Healing and Treatments
- Herbal Medicine Research Studies
- Salmonella and Campylobacter epidemiology
- Moringa oleifera research and applications
- Amoebic Infections and Treatments
- Mesenchymal stem cell research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Tea Polyphenols and Effects
Universidade de São Paulo
2016-2025
Universidade Federal de Minas Gerais
2015-2024
Universidade de Ribeirão Preto
2022
Irvine University
2016
University of California, Irvine
2016
Diabetes mellitus (DM) is a chronic disease and major cause of mortality morbidity worldwide. The hyperglycemia caused by DM induces micro macrovascular complications that lead, among other consequences, to wounds amputations. Cell therapy tissue engineering constitute recent therapeutic alternatives improve wound healing in diabetic patients. current study aimed analyze the effectiveness biocuratives containing human mesenchymal stem cells (MSCs) associated with hydrogel matrix process...
Increased oxidative stress and apoptosis are key mechanisms of thymic atrophy induced by cyclophosphamide (CYP). Atrophy leads to changes in the microenvironment disrupts T cell maturation. The hormone melatonin displays antioxidant antiapoptotic effects. Here, we tested hypothesis that would act as a cytoprotective agent against harmful effects CYP thymus. A single dose (300 mg/kg; ip) was injected male C57BL/6 mice pretreated or not with (10 mg/kg/day, for 4 days. Atrophy, markers,...
Background: Gut microbiota impacts host homeostasis and diseases. Chronic plus binge ethanol consumption has been linked to increased injuries than chronic or intake alone. We hypothesized that distinct shapes in gut composition are induced by chronic, the association of these treatments, thereby affecting functions contributing sex-based differences alcohol use disorders. Methods: Male female C57BL/6J mice were submitted feeding. DNA was extracted from fecal microbiota, followed analysis...
Abstract Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affects T1D remains uncertain. Using streptozotocin-induced (STZ) mouse model, we studied INU's protective effects. Remarkably, STZ + mice resisted T1D, with none developing disease. They had lower blood glucose, reduced pancreatic inflammation, and...
Helminth infection can reduce the severity of inflammatory bowel disease. However, modulatory mechanisms elicited by helminth are not yet fully understood and vary depending on experimental model. Herein we evaluated effect acute BALB/c mice with Strongyloides venezuelensis clinical course ulcerative colitis induced Dextran Sulfate Sodium (DSS) treatment these animals. For experiments, S. venezuelensis-infected were treated orally 4% DSS solution for seven days. As controls, used untreated...
Intestinal permeability and bacterial translocation are increased in obesity metabolic syndrome (MS). ILC3 cells contribute to the integrity of intestinal epithelium by producing IL-22 via IL-1β IL-23. This study investigates role IL-1R1 inducing conferring protection during MS. For this purpose, C57BL/6 wild-type (WT) IL-1R1-deficient mice were fed a standard diet (SD) or high-fat (HFD) for 16 weeks. Weight blood glucose levels monitored, adipose tissue samples collected evaluate...
Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis on immune response, schistosome burden, and associated pathology schistosomiasis in mice. Co-infection did not alter parasite reduced IL-4/IL-10 ratio during acute schistosomiasis, indicating induction modulatory mechanisms. Simultaneous infection with S. mansoni increased liver concentration IFN-γ altered Th2/Th1 balance, leading to...
Cryptococcosis is a systemic mycosis that causes pneumonia and meningoencephalitis. Strongyloidiasis chronic gastrointestinal infection caused by parasites of the genus Strongyloides. strongyloidiasis affect lungs are more prevalent in same world regions, i.e., Africa tropical countries such as Brazil. It undeniable those coincidences may lead to occurrence coinfections. However, there no studies focused on interaction between Cryptococcus spp. Strongyloides In this work, we aimed...
Wild mammals, especially rodents, can participate in the life cycle of
The aim of the present study was to perform histopathological and enzymatic evaluation intestines Swiss mice infected with Strongyloides venezuelensis after oral administration fungus Duddingtonia flagrans (AC001). Twenty were used, all previously dewormed kept in individual cages granulated feed drinking water provided ad libitum. After this period, animals randomly divided into four experimental groups: Group 1 (animals 700 L3 S. venezuelensis), 2 + orally treated 500 chlamydospores...
Schistosomiasis is a neglected tropical disease caused by worms of the genus Schistosoma spp. The progression results in intense tissue fibrosis and high mortality rate. After egg deposition adult worms, inflammatory response characterized robust activation type 2 immunity. Monocytes macrophages play critical roles during schistosomiasis. Inflammatory Ly6Chigh monocytes are recruited from blood to foci differentiate into alternatively activated (AAMs), which promote repair. common chain...
Species of Strongyloides infect a wide range hosts worldwide. Due to their complex life cycle, it is hard control the transmission these parasites. Several species show evidence vertical transmission; however, impact this route on susceptibility offspring has been poorly investigated. Herein, we used venezuelensis infected mice evaluate transplacental and transmammary parasite effect offspring. Swiss female were at end gestation or during breastfeeding period, examined for presence one week...