A5022481664- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Blood properties and coagulation
- Cutaneous Melanoma Detection and Management
- Sphingolipid Metabolism and Signaling
- Hemophilia Treatment and Research
- Dermatology and Skin Diseases
- Integrated Circuits and Semiconductor Failure Analysis
- Nonmelanoma Skin Cancer Studies
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Congenital heart defects research
- Microfluidic and Bio-sensing Technologies
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Nail Diseases and Treatments
- Erythrocyte Function and Pathophysiology
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cell Adhesion Molecules Research
- Cardiovascular Disease and Adiposity
Ludwig-Maximilians-Universität München
2014-2015
Center for NanoScience
2015
German Centre for Cardiovascular Research
2015
Goethe University Frankfurt
2015
University Hospital Frankfurt
2015
University of Bern
2015
Shanghai East Hospital
2015
Novartis (Switzerland)
2015
Novartis Institutes for BioMedical Research
2015
Max Planck Institute for Heart and Lung Research
2002-2014
Platelets are known to play a crucial role in hemostasis. Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine bioactive metabolite 1-phosphate (S1P). Although platelets able secrete S1P on activation, little is about potential intrinsic effect platelet function.To investigate Sphk1- Sphk2-derived regulation function.We found 100-fold reduction intracellular levels derived from Sphk2(-/-) mutants compared with Sphk1(-/-) or wild-type mice, as analyzed by mass...
Keratinocyte cancers, also referred to as non-melanoma skin cancers (NMSCs), are one of the most common malignant tumors. We performed a retrospective analysis lesions from patients private dermatology practice evaluate use electrical impedance spectroscopy (EIS) in detecting keratinocyte malignancies. The aim study is assess accuracy technique and rate its supportive tool NMSC diagnosis.The period evaluated ranges September 2015 November 2019. In total, 1712 951 were included. All...
An athlete's skin has to cope with various stressors that influence integrity. This study investigated the effect of intense sporting activity at a competitive level on health, independent type sport. The prevalence dermatoses in elite athletes who exercise 8 or more hours per week was compared recreational athletes. By applying questionnaire, we acquired data from n=492 recruited and regarding dermatoses, extent physical activity, sports discipline practiced. Compared reference group,...
There has recently been an increased interest in the use of novel automated technologies for early detection skin malignancies. We performed a retrospective analysis clinical effectiveness electrical impedance spectroscopy (EIS) detecting malignancies everyday setting. After thorough visual examination and dermoscopy, 909 abnormal lesions suspicious malignancy were detected 481 patients who presented private dermatology practice between 2015 2017 evaluated with EIS system. The...
Various models exist for the study of platelet and leukocyte function under flow conditions. Flow chambers offer unique possibility to analyze cell-cell cell-surface interactions at a great variety However, working with small animals (i.e. mice) strongly limits amount isolated cells available perfusion. Here, we present chamber technique based on volume multichannel perfusion chamber. First, studied interaction murine platelets diverse matrix proteins in parallel experiments using...
Background: Arterial (AT) and venous thromboses (VT) are the major causes of morbidity in industrialized countries. While critical contribution platelets to AT has been recognized, molecular cellular mechanisms that trigger development VT not yet fully understood. Methods: We established a novel model VT, where thrombus formation occurs after stasis absence mechanical endothelial injury. In contrast published models, our approach closely resembles triggers lead humans. The events were...
Background: Pathological fibrin formation is a predominant cause for arterial thrombosis, triggering myocardial infarction and stroke. Tissue factor (TF), which expressed by vascular endothelium cell-derived microparticles, central trigger of intravascular generation. In intact blood vessels, TF only minimally active, the coagulation system down-regulated. contrast, rapidly stimulated following endothelial disruption. However, molecular mechanisms that via regulation activation are largely...
Objective: Venous thromboembolism has a major medical impact and is the third leading cause of cardiovascular associated death. While critical contribution platelets to arterial thrombosis been recognized, mechanisms that trigger development deep vein (DVT) are not yet fully understood believed be mainly dependent on coagulation. Current in vivo models with endothelial disruption or complete stasis only incompletely reflect pathophysiology DVT humans hinder further understanding this...