A5071170391- Semiconductor Quantum Structures and Devices
- Quantum and electron transport phenomena
- Semiconductor Lasers and Optical Devices
- Molecular Junctions and Nanostructures
- Cell Adhesion Molecules Research
- Quantum optics and atomic interactions
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Electrostatic Discharge in Electronics
- Quantum Dots Synthesis And Properties
- Platelet Disorders and Treatments
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Angiogenesis and VEGF in Cancer
- Sarcoma Diagnosis and Treatment
- Photonic and Optical Devices
- Gastrointestinal motility and disorders
- Integrated Circuits and Semiconductor Failure Analysis
- Spectroscopy and Laser Applications
- Cardiac pacing and defibrillation studies
- Neuroblastoma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Cardiac Arrhythmias and Treatments
- Lung Cancer Research Studies
- Chemokine receptors and signaling
Krankenhaus der Elisabethinen
2024
Montefiore Medical Center
2024
Albert Einstein College of Medicine
2024
Technical University of Munich
2003-2023
Infineon Technologies (Germany)
2015-2023
University Hospital Regensburg
2020
Hamburg Institut (Germany)
2019
Infineon Technologies (United Kingdom)
2018
ift Rosenheim
2015
Helmholtz Zentrum München
2014
The accumulation of smooth muscle and endothelial cells is essential for remodeling repair injured blood vessel walls. Bone marrow–derived progenitor have been implicated in vascular remodeling; however, the mechanisms underlying their recruitment to site injury remain elusive. Here, using real-time vivo fluorescence microscopy, we show that platelets provide critical signal recruits CD34+ bone marrow c-Kit+ Sca-1+ Lin− sites injury. Correspondingly, specific inhibition platelet adhesion...
We show how the optical properties of a single semiconductor quantum dot can be controlled with small dc voltage applied to gate electrode. find that transmission spectrum neutral exciton exhibits two narrow lines $\sim 2$ $\mu$eV linewidth. The splitting into linearly polarized components arises through an exchange interaction within exciton. turned off by choosing where is occupied additional electron. Saturation spectroscopy demonstrates behaves as two-level system. Our experiments...
The fine structure of the neutral exciton in a single self-assembled InGaAs quantum dot is investigated under effect an applied uniaxial stress. spectrum excitonic Rayleigh scattering was measured reflectivity using high-resolution laser spectroscopy while sample submitted to tunable stress along its [110] crystal axis. We show that this stretching technique, potential elastically deformable such splitting can be substantially reduced.
The fine structure of the neutral exciton in a single self assembled InGaAs quantum dot is investigated under effect lateral electric field. Stark shifts up to 1.5 meV, an increase linewidth, and decrease photoluminescence intensity were observed due We show that field strongly affects splitting active manipulation particle wave-functions. Remarkably, can be tuned over large values through zero.
AimsThe purpose of this study was to determine the feasibility a new positron emission tomography (PET) imaging approach using an 18F-labelled αvβ3 integrin antagonist (18F-Galacto-RGD) monitor expression after myocardial infarction.
Histamine is a major mast cell mediator of immunoneural signalling in the gut and cells play role pathophysiology functional inflammatory bowel diseases. receptors are therefore promising drug targets to treat disorders. We aimed study so far unknown effect histamine on neural activity human enteric nervous system (ENS) identify pharmacology response. used fast imaging techniques combination with potentiometric dye di-8-ANEPPS monitor directly membrane potential changes thereby neuronal...
There is a need for in vivo monitoring of cell engraftment and survival after cardiac transplantation therapy. This study assessed the feasibility usefulness combined PET MRI transplantation. <b>Methods:</b> Human endothelial progenitor cells (HEPCs), derived from CD34+ mononuclear umbilical cord blood, were retrovirally transduced with sodium iodide symporter (NIS) gene reporter imaging by <sup>124</sup>I-PET labeled iron oxides visualization MRI. Imaging histologic analysis performed on 3...
Epidermal growth factor receptor (EGFR) overexpression and activation are hallmarks of non-small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies used, the prognosis NSCLC remains poor. ADAM17 induces EGFR through ligand cleavage. However, we show that inhibition or knockdown markedly reduces tumorigenesis survival to a large part independently from shedding in cells. These findings strongly indicate additional oncogenic mechanisms regulated by ADAM17. We identified Notch1...
<i>Objectives:</i> Abdominal aortic aneurysm (AAA) wall is characterized by degradation of extracellular matrix through metalloproteinases (MMPs), chronic inflammatory cell infiltration and extensive neovascularization. So far, MMP expression within AAA in association with infiltrates neovascularization has not yet been studied. <i>Methods:</i> Vessel walls 15 patients 8 organ donors were analyzed immunohistochemistry for various MMPs (MMP-1, -2, -3, -7, -8, -9, -12...
Aims Currently pulmonary carcinoids are separated into typical and atypical based on mitotic count presence of necrosis, according to the World Health Organization. At variance with gastroenteropancreatic neuroendocrine tumours, which graded Ki‐67 proliferative index, use for grading is still under debate. Methods results In this study we evaluated prognostic impact assessment in a multicentre cohort 201 [147 ( TC s) 54 AC s)] using manual analysis (2000 cells counted) digital image...
The serine protease MT-SP1/matriptase plays an important role in cell migration and matrix degradation. Hepatocyte growth factor (HGF), urokinase-type plasminogen activator (uPA), protease-activated receptor 2 (PAR-2) have been identified as vitro substrates of MT-SP1/matriptase. Because PAR-2 is expressed endothelial cells contributes to inflammatory processes, we sought investigate the effects on cytokine expression analyzed vascular atherosclerotic lesions.In cells, recombinant...
We determine the impact of anharmonic thermal vibrations on fundamental band gap ${\mathrm{CsPbBr}}_{3}$, a prototypical model system for broader class halide perovskite semiconductors. Through first-principles molecular dynamics and stochastic calculations, we find that fluctuations are key effect in electronic structure these materials. present experimental theoretical evidence important characteristics, such as mildly changing band-gap value across temperature range includes phase...
We have performed detailed photoluminescence (PL) and absorption spectroscopy on the same single self-assembled quantum dot in a charge-tunable device. The transition from neutral to charged exciton PL occurs at more negative voltage than corresponding absorption. developed model of Coulomb blockade account for this observation. At large bias, broadens as result electron hole tunneling. observe resonant features regime whenever level is with two-dimensional states located capping...
Abstract Neuroimmune interactions are an integral part of gut physiology and involved in the pathogenesis inflammatory functional bowel disorders. Mast cells their mediators important conveyors communication from innate enteric immune system to nervous (ENS). However, it is not known whether a mediator cocktail released activated human mast affects neural activity ENS. We used Multi‐Site Optical Recording Technique image single cell guinea‐pig ENS after application (MCMC) that was isolated...
Background— Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. Methods Results— The aim of the present study was to evaluate impact RNA interference on replication, cytopathogenicity, survival. Small interfering (siRNA) molecules were designed against 2A region (siRNA-2A), which considered be highly conserved essential for both virus maturation host...