Abstract Objectives: This study aimed to establish a method determine workers’ exposure concentrations airborne nitrilotriacetic acid (NTA). Methods: The sampler used an air sampling cassette containing glass fiber filter (GFF). After sampling, NTA extracted from the GFF using ultrapure water was derivatized boron trifluoride-methanol complex methanol solution and analyzed gas chromatograph-mass spectrometer. developed validated for following parameters: retention efficiency, storage...

Unmetabolized VOCs in Urine as Biomarkers of Low Level Exposure Indoor Environments: Bing‐Ling W ang , et al . Department Public Health, Okayama University Graduate School Medicine, Dentistry and Pharmaceutical Sciences —This study aimed to test the possible use unmetabolized volatile organic compounds (VOCs) urine biomarkers low‐level indoor environmental exposure. Twenty‐four subjects 13 dwellings a prefecture Japan participated this study. Air samples breathing zone were collected living...

This study describes an ecological that evaluated the combined effects of working hours, income, and leisure time on suicide in all 47 prefectures Japan. In men, age-adjusted rate (per 100,000 population) was significantly correlated with hours (r=0.587, p<0.0001) as well negatively income (r=-0.517, p=0.0002) times for activities self-education (r=-0.447, p=0.0016) hobbies (r=-0.511, p=0.0002). addition, a stepwise multiple regression analysis identified social determining factor rate, even...

Abstract A method for routinely determination of dimethyl sulfoxide (DMSO) and sulfone (DMSO 2 ) in human urine was developed using gas chromatography–mass spectrometry. The sample treated with 2,2‐dimethoxypropane (DMP) hydrochloric acid efficient removal water, which causes degradation the vacuum level mass spectrometer shortens life‐time column. Experimental DMP reaction parameters, such as concentration, DMP–urine ratio, temperature time, were optimized urine. Hexadeuterated DMSO used an...

We report on a patient presenting with an isolated polyneuropathy mimicking Guillain-Barré syndrome (GBS) associated arsenic exposure.A 43-year-old man visited our emergency room complaining of progressive quadriparesis over the prior 5 days. His clinical course laboratory data was typical GBS. However, because his recent use herbal medication, we screened for presence several heavy metals. Serial analyses urinary inorganic concentrations confirmed exposure to arsenic. He diagnosed as...

A sequential analytical method was developed for the detection of arsenite, arsenate, and methylarsenate in human urine by gas chromatography‐mass spectrometry ( GC ‐ MS ). The combination a derivatization trivalent arsenic compounds 2,3‐dithio‐1‐propanol B ritish antilewisite; BAL ) reduction pentavalent (arsenate methylarsenate) were accomplished to carry out analysis urine. derivatives obtained using extracted stepwise manner monolithic spin column analyzed . linear curve observed...

Abstract Objectives The purpose of this study was to develop a simple and accurate gas chromatography-mass spectrometry (GC-MS) method for simultaneous determination four urinary metabolites from organic solvents, that is, hippuric acid (HA) toluene, methylhippuric (MHA) xylene, mandelic (MA) phenylglyoxylic (PGA) styrene or ethylbenzene biological monitoring. Methods were directly methyl-esterified with 2,2-dimethoxypropane analyzed using GC-MS. proposed validated according the US Food Drug...

The purpose of this study was to develop an analytical method for the simultaneous determination inorganic arsenic [As(III) and As(V)] monomethylarsonic acid (MMA) in urine by gas chromatography-mass spectrometry (GC-MS) biological monitoring exposure arsenic.Arsenic compounds (after reduction trivalent state) were derivatized with 2,3-dimercapto-1-propanol then analyzed using a GC-MS. proposed validated according US Food Drug Administration guidelines. accuracy confirmed analyzing Standard...

AbstractThe purposes of the present study are (1) to develop a sensitive analytical method measure 1-bromopropane (1-BP) in urine, (2) examine if 1-BP or bromide ion (Br) urine is useful biomarker exposure 1-BP, and (3) identify lowest concentration thus established can biomonitor. A factory survey was carried out on Friday, 33 workers (all men) cleaning painting workshops participated; each worker equipped with diffusive sampler (carbon cloth KF-1500 as an adsorbent) monitor vapour for 8-h...

Acetoaceto-o-toluidide (AAOT) is made from ortho-toluidine (OTD) and used for the synthesis of pigments. A report occupational urinary bladder carcinomas in Japanese workers chronically exposed to OTD AAOT has recently been published. a well-known human carcinogen; however, little known about toxicity carcinogenicity AAOT. The aim present study evaluate toxic effects on epithelium. In vitro, cytotoxicities were evaluated rat (MYP3) (1T1) urothelial cells. LC50 was higher than that both MYP...

Determination Method for Mono‐ and Diethanolamine in Workplace Air by High‐performance Liquid Chromatography: Akito TAKEUCHI, et al . Osaka Occupational Health Service Center, Japan Industrial Safety Association— Objectives The purpose of this research was to develop a simultaneous determination method monoethanolamine (MEA) diethanolamine (DEA) workplace air risk assessment. Methods characteristics the proposed method, such as recovery, quantitation limit, reproducibility storage stability...

The present study was initiated to examine if application of the same biological occupational exposure limits (BOELs) for organic solvents is applicable across sexes.A survey conducted in 69 micro-scale enterprises a furniture-producing industrial park. In practice, 211 men and 52 women participated survey. They worked series production process, were exposed solvent vapor mixtures. intensities monitored with two types diffusive samplers, one carbon cloth (for general) other water methyl...

Determination Method for Nitromethane in Workplace Air: Akito T akeuchi , et al . Osaka Occupational Health Service Center, Japan Industrial Safety and Association Objectives The purpose of this research was to develop a determination method nitromethane (NM) workplace air risk assessment. Methods A suitable sampler appropriate desorption condition were selected by recovery test which spiked used. characteristics the proposed method, such as recovery, detection limit, reproducibility,...

Abstract Objectives The aim of this study was to develop and validate a simple reliable gas chromatography-mass spectrometry (GC-MS) method simultaneously determine urinary 1-naphthol (1-NAP) 2-naphthol (2-NAP) for biological monitoring occupational exposure naphthalene. Methods NAPs were derivatized in situ with acetic anhydride after enzymatic hydrolysis, extracted n-hexane, analyzed using GC-MS. Validation the proposed conducted accordance US Food Drug Administration guidance. A final...

Abstract Objectives The purpose of this research was to develop and validate an analytical method for rapid determination the exposure workers ortho-phthalaldehyde (OPA) at ceiling threshold concentration. Methods A 2,4-dinitrophenylhydrazine (DNPH)-silica cartridge chosen as a sampler. OPA collected by DNPH-silica subsequently extracted with 5 mL acetonitrile. 50-µL aliquot phosphoric acid/acetonitrile solution (2%, v/v) added 950 µL extraction allowed stand 30 minutes room temperature....

The aim of the present study was to comparatively evaluate usefulness urinary cyclohexanediols (CHdiols-U) and cyclohexanol (CHol-U) as biomarkers occupational exposure cyclohexane (CH).Sixteen subjects (14 men 2 women) were exposed CH during proof-printing work. Personal monitoring conducted whole shift on last working day week. time-weighted average level (CH-A) measured using a diffusive sampler. Two urine samples collected from each worker at different times same week: baseline sample...

The purpose of this research was to develop a determination method for xylidines (XLDs) in workplace air risk assessment.The characteristics the proposed method, such as recovery, detection limit, reproducibility, and storage stability samples were examined.An sampler cassette containing two sulfuric acid-treated glass fiber filters chosen sampler. XLDs extracted from filters, derivatized with heptafluorobutyric anhydride, then analyzed by gas chromatograph equipped mass spectrometer....