A5070428760- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Oral and gingival health research
- Immune Response and Inflammation
- Regulation of Appetite and Obesity
- Eosinophilic Esophagitis
- Inflammatory mediators and NSAID effects
- Vascular Malformations and Hemangiomas
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS oral health manifestations
Newcastle University
2010-2020
Naresuan University
2013-2015
In-Q-Tel
2015
Armed Forces Research Institute of Medical Science
2008
British Society of Periodontology
2008
Chulalongkorn University
2008
Summary Interleukin‐33 (IL‐33) is an IL‐1 family cytokine that has a role in regulating T helper type 2 cytokines and mast cell development. Expression of IL‐33 also associated with chronic inflammatory conditions such as rheumatoid arthritis. However, there little information regarding myeloid immune responses, which are important immunity inflammation. We therefore investigated the expression, intracellular location regulation by lipopolysaccharide (LPS) from Escherichia coli periodontal...
Abstract Aims To assess the impact of periodontal treatment on systemic inflammation in type 2 diabetes. Materials and Methods Adults with diabetes ( n = 83) without (controls, 75) were recruited, participants periodontitis received 12 months’ follow‐up. Biomarkers for (gingival crevicular fluid interleukin‐6, tumour necrosis factor‐α, interleukin‐1β, interferon‐γ, matrix metalloproteinase‐8, metalloproteinase‐9, adiponectin) serum markers control (glycated haemoglobin, high sensitivity...
Interleukin (IL)-17 is present in inflammatory periodontal lesions, thus suggesting a role mediating inflammation. We tested the hypothesis that IL-17, especially when combined with interferon (IFN)-γ, may modulate responses of human gingival fibroblasts (HGFs). IL-17 induced IL-8 and minimal intercellular adhesion molecule (ICAM)-1 expression. It had no effect on expression HLA-DR, CD40, or immune-suppressive enzyme indoleamine 2,3-dioxygenase (IDO). The effects HGFs were compared those...
Female sex hormones are elevated and potential host response modifiers during pregnancy. Modulation of immune responses by estrogen progesterone may be responsible for periodontal inflammation. Therefore, we aimed to investigate the role β-estradiol in human monocyte responses, at cellular molecular levels, identify their as a possible immunological link between pregnancy disease.Primary monocytes were purified from peripheral blood mononuclear cells adherent method. Expression Toll-like...
Davies RC, Jaedicke KM, Barksby HE, Jitprasertwong P, Al‐Shahwani RM, Taylor JJ, Preshaw PM. Do patients with aggressive periodontitis have evidence of diabetes? A pilot study. J Periodont Res 2011; 46: 663–672. © 2011 John Wiley & Sons A/S Background and Objective: Complex relationships exist between diabetes periodontal disease. Diabetes is accepted as a risk factor for disease, recent supports the existence bidirectional relationship these two diseases. It has been hypothesized that...
Progesterone and estrogen levels are elevated during pregnancy play a role in maternal immune responses. In addition, unbalanced metabolism of growth factors has been demonstrated tumors. Therefore, we aimed to investigate the effect progesterone β-estradiol on vascular endothelial factor-A (VEGF-A) basic fibroblast factor (bFGF) messenger RNA (mRNA) expression THP-1 monocytes response Porphyromonas gingivalis lipopolysaccharide (LPS). were incubated with progesterone, β-estradiol, or LPS...