A5049034924- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Resistance in Staphylococcus
- Microbial infections and disease research
- Salmonella and Campylobacter epidemiology
- Parasitic Infections and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Pregnancy and preeclampsia studies
- Job Satisfaction and Organizational Behavior
- Thyroid Disorders and Treatments
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Urban Agriculture and Sustainability
- Birth, Development, and Health
- Community Development and Social Impact
- Energy, Environment, Economic Growth
- Belt and Road Initiative
- Immunotherapy and Immune Responses
- Bacterial biofilms and quorum sensing
- Virus-based gene therapy research
- Growth Hormone and Insulin-like Growth Factors
Murdoch University
2016-2025
Nova Southeastern University
2020-2024
Malabar Medical College Hospital and Research Centre
2023
University of Chicago Medical Center
2023
The University of Adelaide
2016-2022
Avinashilingam University
2021
Fiona Stanley Hospital
2016
Christian Medical College & Hospital
1997-2012
Christian Medical College
2002-2012
Pondicherry Institute of Medical Sciences
2008-2009
Abstract Objectives Antimicrobial resistance (AMR) to critically important antimicrobials (CIAs) amongst Gram-negative bacteria can feasibly be transferred wildlife, humans and domestic animals. This study investigated the ecology, epidemiology origins of CIA-resistant Escherichia coli carried by Australian silver gulls (Chroicocephalus novaehollandiae), a gregarious avian wildlife species that is common inhabitant coastal areas with high levels human contact. Methods Sampling locations were...
Methicillin-resistant coagulase-positive staphylococci (CoPS) have become increasingly recognised as opportunistic pathogens that limit therapeutic options in companion animals. The frequency of methicillin resistance amongst clinical isolates on an Australia-wide level is unknown. This study determined antimicrobial susceptibility patterns for CoPS isolated from infections animals (dogs, cats and horses) part the first nation-wide survey animal Australia a one-year period (January 2013 to...
Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options treat such infections. CREs have been predominantly isolated from humans and environmental samples they rarely reported among companion animals. In this study we report on the isolation plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium animal. Carbapenemase-producing S. carrying blaIMP-4 was identified systemically unwell (index) cat...
In a structured survey of all major chicken-meat producers in Australia, we investigated the antimicrobial resistance (AMR) and genomic characteristics
Abstract This study investigated the ecology, epidemiology and plasmid characteristics of extended-spectrum cephalosporin (ESC)-resistant E. coli in healthy pigs over a period 4 years (2013–2016) following withdrawal ESCs. High carriage rates ESC-resistant were demonstrated 2013 (86.6%) 2014 (83.3%), compared to 2015 (22%) 2016 (8.5%). ESC resistance identified among isolates was attributed an IncI1 ST-3 (pCTXM1-MU2) encoding blaCTXM-1. Genomic characterisation selected (n = 61) movement...
The World Health Organisation has defined "highest priority critically important antimicrobials" (CIAs) as those requiring the greatest control during food production. Evidence demonstrating that restricted antimicrobial usage prevents emergence of resistance to CIA's amongst pathogenic and commensal organisms on a production system-wide scale would strengthen international efforts (AMR). Therefore, in designed survey all major chicken-meat producers Australia, we investigated phenotypic AMR...
This study aimed to determine the frequency and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) from Australian animals whether animal-derived MRSA was similar that veterinarians. A total 1,080 clinical coagulase positive isolates were collected during 2013. Sixteen (4%) 360 S. MRSA. Most came companion animals, while none livestock. characterized using whole genome sequencing. ST22-IV (EMRSA-15) most common clone in dogs cats. Clonal complex (CC) 8 horses....
Robenidine, 1 (2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide), was active against MRSA and VRE with MIC's of 8.1 4.7 μM, respectively. SAR revealed tolerance for 4-Cl isosteres 4-F (8), 3-F (9), 3-CH3 (22), 4-C(CH3)3 (27) (23.7–71 μM) 3-Cl (3), 4-CH3 (21), 4-CH(CH3)2 (26) (8.1–13.0 μM). Imine carbon alkylation identified a methyl/ethyl binding pocket that also accommodated CH2OH moiety (75; 2,2′-bis[1-(4-chlorophenyl)-2-hydroxyethylidene]carbonimidic dihydrazide). Analogues 1,...
Due to Australia's management of antimicrobial use in poultry, particularly the discontinued avoparcin for nearly 20 years, it is hypothesized that vancomycin-resistant enterococci associated with human disease are not derived from poultry isolates. This study evaluated resistance (AMR) five enterococcal species isolated Australian meat chickens, genomic features
The increasing resistance of bacteria to antimicrobials is a major threat public health. This study investigates the prevalence antimicrobial resistance, both phenotypic and genotypic, among Campylobacter isolates from Australian meat chickens in 2022, as follow up investigate trends since last national surveillance undertaken 2016. Isolates (n = 186) were obtained at slaughter 200 pooled cecal samples taken 1,000 chickens. majority C. jejuni (68.7%) coli (88.9%) susceptible all antibiotics...
It has been shown that 20% of Australian silver gulls carry drug-resistant Escherichia coli strains anthropogenic origin associated with severe diseases, such as sepsis and urinary tract infections, in humans. To further characterize the dynamics E. wildlife populations, we investigated carriage critically important antimicrobial (CIA) four bird species a common environment. Our results indicated gulls, pigeons, penguins carried strains, analysis mobile genetic elements resistance genes...
Infection with Pasteurella multocida represents a significant economic threat to Australian pig producers, yet our knowledge of its antimicrobial susceptibilities is lagging, and genomic characterization P. strains associated porcine lower respiratory disease internationally scarce. This study utilized high-throughput robotics phenotypically genetically characterize an industry-wide collection 252 clinical isolates that were recovered between 2014 2019. Overall, resistance was found be low,...
Enterococci are ubiquitous opportunistic pathogens that have become a major public health issue globally. The increasing prevalence of antimicrobial resistance in hospital-adapted enterococci had been thought to originate from livestock. However, this association between livestock and is currently unclear. This study investigates the susceptibilities isolated pig cecal samples compares genomic characteristics Enterococcus faecium pigs those isolates meat chickens human sepsis cases. From 200...
Surveillance of antimicrobial resistance (AMR) is critical to reducing its wide-reaching impact. Its reliance on sample size invites solutions longstanding constraints regarding scalability. A robotic platform (RASP) was developed for high-throughput AMR surveillance in accordance with internationally recognized standards (CLSI and ISO 20776-1:2019) validated through a series experiments.Experiment compared RASP's ability achieve consistent MICs that human technician across eight replicates...
Abstract Camp dogs in indigenous communities the Western Australian Kimberley Region, share domestic environment with humans and have potential to act as carriers of, sentinels for, a wide range of zoonotic agents, including intestinal parasites antimicrobial resistant bacteria. In this study, we investigated carriage extended-spectrum-cephalosporin-resistant (ESC-resistant) Escherichia coli , methicillin-resistant Staphylococcus aureus (MRSA) species hookworm Giardia among camp remote...