A5045565504- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Antibiotic Resistance in Bacteria
- Plant Disease Resistance and Genetics
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Plant-Microbe Interactions and Immunity
- Enterobacteriaceae and Cronobacter Research
- Genomics and Phylogenetic Studies
- Wheat and Barley Genetics and Pathology
Montefiore Medical Center
2024
Albert Einstein College of Medicine
2024
Norwich Research Park
1999
John Innes Centre
1997-1999
Trichothecene-producing and -nonproducing Fusarium graminearum strains were tested for their ability to cause Gibberella ear rot in field trials at two locations-Ottawa, Ontario, Peoria, Illinois-in 1996. Maize ears inoculated with wild-type or transgenic F. which the trichothecene biosynthetic pathway had been disabled by specific disruption of trichodiene synthase gene a derivative revertant strain production restored through recombination. A silk channel inoculation method was employed...
The Tri5 gene encodes trichodiene synthase, which catalyzes the first reaction in trichothecene biosynthetic pathway. In vitro, a direct relationship was observed between expression and increase deoxynivalenol production over time. We developed reverse transcription (RT)-PCR assay to quantify trichothecene-producing strains of Fusarium species. an following treatment culmorum with fungicides, we also inverse biomass, as measured by beta-D-glucuronidase activity, during colonization wheat...
Abstract Background Use of anti-carbapenem-resistant Enterobacterales (anti-CRE) agents such as ceftazidime/avibactam has been associated with improved clinical outcome in cohorts that primarily include patients infected CRE are resistant to meropenem (MCRE). Objectives To clarify whether ertapenem but susceptible (ertapenem-only-resistant Enterobacterales; EORE) benefit from therapy anti-CRE agents. Methods Patients treated for infection hospitals the USA between 2016 and 2019 enrolled...
Abstract Background The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVID-19 pandemic. We evaluated patient outcomes following HO and community-onset (CO) CRE bloodstream (BSI). Methods Patients prospectively enrolled CRACKLE-2 from 56 hospitals 10 countries between 30 April 2016 November 2019 with BSI were eligible. Infections defined as CO or by guidelines, clinical characteristics compared. primary outcome was...
Abstract Background Despite the global public health threat posed by carbapenem-resistant Enterobacter spp, clinical and molecular epidemiological studies on international isolates remain scarce. Historically, taxonomy of has been challenging, limiting our understanding characteristics outcomes carbapenemase-producing spp infections. Methods Hospitalized patients enrolled in CRACKLE-2 study (ClinicalTrials.gov, NCT03646227) from 2016 to 2018 with cultures positive for were included. Clinical...