A5045933628- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Amyotrophic Lateral Sclerosis Research
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
Huazhong University of Science and Technology
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Wuhan University
2022-2023
Renmin Hospital of Wuhan University
2022-2023
Jinan University
2022
Abstract Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged maintain cellular homeostasis. physically functionally interact with lysosomes regulate metabolism. However, mode biological functions of mitochondria-lysosome communication remain largely unknown. Here, we show hypoxia remodels normal tubular mitochondria into megamitochondria...
Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, molecular mechanism physiological function endoplasmic reticulum-mitochondrial remain unclear. Here, we show that Mic19, a key subunit MICOS (mitochondrial contact site cristae organizing system) complex, regulates ER-mitochondria by EMC2-SLC25A46-Mic19 axis. Mic19 liver specific knockout (LKO) leads to reduction ER-mitochondrial contacts, mitochondrial...
Abstract Mitochondrial dysfunction is becoming one of the main pathology factors involved in etiology neurological disorders. Recently, mutations coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10 (CHCHD10) which encode two homologous proteins that belong to mitochondrial CHCH protein family, are linked Parkinson’s disease amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), respectively. However, physiological pathological roles these twin have not been...
Mitochondria are important organelles of eukaryotic cells and involved in a variety cellular processes including oxidative phosphorylation for generating ATP, apoptosis, steroid synthesis, signal transduction. Mitochondrion contains double membranes, which mainly composed phospholipids. Although mitochondria can synthesize some phospholipids, most phospholipids biosynthesized the endoplasmic reticulum (ER). ER-mitochondria contacts required transfer critical mitochondrial metabolism,...
Abstract Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to produce ATP power cell. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles, including mitochondria, maintain cellular homeostasis. physically functionally interact with lysosomes regulate metabolism. However, mode biological functions of mitochondria-lysosome communication remain largely unknown. Here, we show hypoxia reshapes normal...