A5087391476- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Bladder and Urothelial Cancer Treatments
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Reproductive tract infections research
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Reproductive System and Pregnancy
- Parathyroid Disorders and Treatments
- Pregnancy and preeclampsia studies
- Blood groups and transfusion
- Renal cell carcinoma treatment
- Bone health and treatments
- Gestational Diabetes Research and Management
- Microbial infections and disease research
- Tannin, Tannase and Anticancer Activities
- Reproductive Physiology in Livestock
- Cancer, Lipids, and Metabolism
Emory University
2019-2025
Piedmont Athens Regional
2022
Emory University Hospital
2019-2020
Society of Nuclear Medicine and Molecular Imaging
2020
Texas A&M University
2016-2019
University of Pittsburgh
2016
Purpose We aimed to evaluate the impact of 18 F-fluciclovine PET/CT imaging on failure-free survival (FFS) post–salvage radiotherapy (SRT) for prostate cancer (PCa) recurrence. Methods Seventy-nine patients were recruited in a phase 2/3 clinical trial undergo before SRT PCa. Four with extrapelvic disease excluded. All followed up at regular intervals 48 months. Treatment failure was defined as serum prostate-specific antigen level ≥0.2 ng/mL above nadir after SRT, confirmed an additional...
326 Background: Fluciclovine PET-guided prostate cancer (PCa) radiotherapy (XRT) improves failure-free survival (FFS) over conventional imaging (CI) alone in post-prostatectomy (RRP) recurrence (EMPIRE-1, PMID: 33971152). In this randomized trial we explored dose-escalation (DE) to sites of PET uptake (not done EMPIRE-1) using either fluciclovine or 68 GaPSMA PET/CT-guided XRT and compared control the arm EMPIRE-1 2Y failure free 79.6%. Methods: From 2019-2023, 140 pts w/ PCa with detectable...
Abstract Background: There are limited studies regarding the tumor microenvironment of aggressive prostatic adenocarcinoma (PCa), at single-cell level. In addition, there is a paucity RNAseq data gene expression immune infiltrates and cancer-associated fibroblasts adjacent to PCa. The Visium-HD Spatial platform sequences formalin-fixed paraffin embedded (FFPE) tissue using spatial barcodes up 2-micron pixel resolution, which achieves resolution. Design: We performed analysis on FFPE blocks...
No AccessJournal of UrologyAdult Urology1 Oct 2020[18F]Fluciclovine Positron Emission Tomography/Computerized Tomography for Preoperative Staging in Patients with Intermediate to High Risk Primary Prostate Cancer Mehrdad Alemozaffar, Akinyemi A. Akintayo, Olayinka Abiodun-Ojo, Dattatraya Patil, Faisal Saeed, Yijian Huang, Adeboye O. Osunkoya, Mark M. Goodman, Martin Sanda, and David Schuster AlemozaffarMehrdad Alemozaffar Department Urology, Emory University School Medicine, Atlanta, Georgia...
Background Ideal management of sexually transmitted infections (STI) may require risk markers for pathology or vaccine development. Previously, we identified common genetic variants associated with chlamydial pelvic inflammatory disease (PID) and reduced fecundity. As this explains only a proportion the long-term morbidity risk, used whole-exome sequencing to identify biological pathways that be STI-related infertility. Methods We obtained stored DNA from 43 non-Hispanic black women PID...
Imaging with novel PET radiotracers has significantly influenced radiotherapy decision making and radiation planning in patients recurrent prostate cancer (PCa). The purpose of this analysis was to report the final results for management changes based on <sup>18</sup>F-fluciclovine PET/CT findings determine whether change trend remained after completion accrual. <b>Methods:</b> Patients detectable prostate-specific antigen (PSA) prostatectomy were randomized undergo either conventional...
We evaluated <sup>18</sup>F-fluciclovine uptake parameters that correlate with true positivity for local recurrence in non–prostatectomy-treated patients. <b>Methods:</b> Twenty-one patients (prostate-specific antigen level, 7.4 ± 6.8 ng/mL) biochemical after nonprostatectomy therapy (radiotherapy and cryotherapy) underwent dual–time-point (364.1 37.7 MBq) PET/CT from pelvis to diaphragm. Prostatic over background was delineated coregistered a prostate-biopsy–planning ultrasound. Transrectal...
Problem Recently characterized interferon epsilon ( IFN e) protects against sexually transmitted infections, including genital herpes simplex virus HSV ), in animal models. There are no reports of e tract secretions pregnant women, and data on non‐pregnant women limited. This pilot study is the first to measure concentrations vaginal cervical during pregnancy compare values between healthy ‐infected women. Method Study Vaginal or specimens from 30 were obtained Global Alliance Prevent...
Objectives: Prostate cancer is well known to express high levels of somatostatin receptors and preliminary data suggests that PET imaging with the analog, [68Ga]Ga-DOTATATE, may allow for whole body staging patients metastatic castration resistant prostate (mCRPC) neuroendocrine (NePC). This study explores utility [68Ga]Ga-DOTATATE PET-CT identify deposits in men mCRPC NePC prognosticate disease progression. Methods: was performed 17 those, 2/17 had NePC. A semiquantitative analysis...
We assessed the feasibility and cancer detection rate of fluciclovine (18F) positron emission tomography-ultrasound fusion targeted biopsy vs standard template in same patient with biochemical failure after nonsurgical therapy for prostate cancer.A total 21 patients a mean ± SD specific antigen 7.4 6.8 ng/ml nonoperative treatment underwent tomography-computerized tomography (mean 364.1 37.7 MBq) planning transrectal ultrasound 3-dimensional image reconstruction. Focal prostatic activity on...
Prostate cancer is a highly heterogeneous disease and mortality mainly due to metastases but the initial steps of metastasis have not been well characterized. We performed integrative whole exome sequencing transcriptome analysis primary prostate tumor foci corresponding lymph node (LNM) from 43 patients enrolled in clinical trial. present evidence that, while there are some cases clonally independent foci, 87% descended common ancestor. demonstrate that genes related oxidative...
The EMPIRE-1 (Emory Molecular Prostate Imaging for Radiotherapy Enhancement 1) trial reported a survival advantage in recurrent prostate cancer salvage radiotherapy (SRT) guided by
This study aimed to explore the effect of infertility on self-esteem and depression, identify sociodemographic characteristics associated with depression among infertile women in Ekiti State, Nigeria. Self-esteem were assessed 100 seeking family planning (controls) using Rosenberg Self-Esteem Scale (RSES) Patient Health Questionnaire (PHQ-9), respectively. Infertile had significantly lower RSES score (19.4 ± 4.5 vs. 20.7 4.4, p=.038) higher PHQ-9 (5.1 4.1 3.8 3.5, p=.023) compared controls....
Prostate cancer is a highly heterogeneous disease, and mortality mainly due to metastases, but the initial steps of metastasis have not been well characterized. We performed integrative whole exome sequencing transcriptome analysis primary prostate tumor foci corresponding lymph node metastases (LNM) from 43 patients enrolled in clinical trial. present evidence that while there are some cases clonally independent foci, 87% descended common ancestor. demonstrate genes related oxidative...
18F-Fluciclovine is an amino acid-based radiopharmaceutical used primarily for PET imaging of patients with biochemical recurrence prostate cancer. We report a case 66-year-old man recently diagnosed metastatic castrate-resistant cancer and left supraclavicular lymph node incidental radiotracer uptake on 18F-fluciclovine PET/CT. Left neck core needle biopsy confirmed high-grade, poorly differentiated carcinoma neuroendocrine features positive synaptophysin chromogranin, negative markers.
217 Background: Neuroendocrine transformation (NE) of prostate cancer is difficult to diagnose and treat. 68 Ga-DOTATATE PET useful detect well-differentiated neuroendocrine tumors, but its application in not well understood. We evaluated DOTATATE patients with mCRPC suspected or known NE. Methods: PET/CT were performed 17 mCRPC. Summed SUVmax up 5 bone soft tissue lesions each patient correlated histologic presence NE response standard care treatment clinical outcome (NCT03448458). Results:...
Abstract 18 F-fluciclovine is a PET radiotracer approved for detection of recurrent prostate cancer, with utility in other malignancies being investigated. We present the case 71-year-old man high-risk primary cancer (Gleason score 9, prostate-specific antigen 34 ng/mL) and newly diagnosed lung adenocarcinoma. As part clinical trial (NCT03081884), preoperative PET/CT showed localized abnormal uptake gland extracapsular extension. Additionally, an incidental anterior mediastinal mass...