A5101731081- Vascular Malformations and Hemangiomas
- Vascular Malformations Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Tumors and Oncological Cases
- Histiocytic Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Head and Neck Surgical Oncology
- Urologic and reproductive health conditions
- Islanding Detection in Power Systems
- Cell Adhesion Molecules Research
- Cardiac tumors and thrombi
- Peripheral Nerve Disorders
- Soft tissue tumor case studies
- Musculoskeletal synovial abnormalities and treatments
- Extracellular vesicles in disease
- Vascular anomalies and interventions
- Nanoparticle-Based Drug Delivery
- Bone Tumor Diagnosis and Treatments
- Congenital Ear and Nasal Anomalies
- CNS Lymphoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Vascular Anomalies and Treatments
- Transplantation: Methods and Outcomes
- Caveolin-1 and cellular processes
- Renal and related cancers
Henan Provincial People's Hospital
2013-2025
Zhengzhou University
2013-2025
Guangdong Province Women and Children Hospital
2023
GTx (United States)
2017
St. Paul's Hospital
1997
University of British Columbia
1997
To develop propranolol-loaded poly(lactic-co-glycolic acid) nanoparticle with CD133 aptamers (PPN-CD133) to treat infantile hemangioma.The antihemangioma activity and mechanism of PPN-CD133 were evaluated.PPN-CD133 are desired size (143.7 nm), drug encapsulation efficiency (51.8%) sustained release for 8 days. could effectively bind CD133+ hemangioma stem cells, resulting in enhanced cytotoxic effect reduced expression angiogenesis factors cells. The therapeutic was superior that untargeted...
Abstract Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that typically presents in infancy or early childhood. As awareness of KHE increases, it imperative the management be updated to reflect latest evidence‐based guidelines. The aim this study was integrate literature and Chinese expert opinions provide recommendations will guide diagnosis, treatment, prognosis patients with KHE. According consensus statement, 28 nationally peer‐recognized experts anomalies an medicine were...
Abstract Background Infantile hemangiomas (IH) are common vascular tumors in infants, with no well-defined therapeutic agents currently available. Recent studies have explored molecular mechanisms involved IH progression, but the lack of immortalized hemangioma-derived endothelial cell (iHemEC) models has limited drug discovery efforts. Methods We established an expressing hemangioma markers and screened 18 potential drugs. Transcriptome profiling Gene Set Enrichment Analysis (GSEA) were...
Purpose: To reduce the adverse effects and high frequency of administration propranolol to treat infantile hemangioma, we first utilized propranolol-loaded liposomes-in-microsphere (PLIM) as a novel topical release system realize sustained propranolol. Methods: PLIM was developed from encapsulating liposomes (PLs) in microspheres made poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) copolymers (PLGA-PEG-PLGA). The profile evaluated, its biological...
We previously developed propranolol-encapsulated liposomes-in-microspheres (PLIM) to realize the sustained propranolol release for treatment of hemangiomas. However, liposomes released from microspheres still lacked specificity CD133-positive hemangioma-derived stem cells (HemSCs) which are considered be seeds Therefore, we hereby encapsulated propranolol-loaded CD133 aptamers conjugated in poly(lactic-co-glycolic acid (PLGA) develop (PCLIM), aim and targeted therapy The evaluation PCLIM was...
Hemangioma (HA) is one of the commonest benign vascular neoplasms infancy. Inhibitor differentiation 1 (ID-1) has been reported to be an oncogene in multiple cancers. However, role ID-1 and its molecular mechanism HA progression have not elucidated. In present study, we found that expression at mRNA protein levels was up-regulated HA-derived endothelial cells (HDECs). Knockdown inhibited proliferation, facilitated apoptosis, enhanced propranolol cytotoxicity HDECs. decreased phospholyrated...
Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor with high risk of mortality. Few studies large samples KHE have been reported. may develop into the Kasabach-Merritt phenomenon (KMP), which characterized by thrombocytopenia and consumptive coagulopathy. The features severe symptomatic anemia life-threatening low platelets make management associated KMP challenging. aim this study was to examine clinical characteristics patients discuss treatment experience for different groups...
Infantile hemangioma (IH) is a benign pediatric tumor, and rapid growth of IH can result in serious morbidity even mortality. Only one drug Hemangeol™ (propranolol hydrochloride oral solution) has been approved for the treatment IH, whereas patients suffer from its adverse effects high frequency administration. We have used urea, an organic compound normal body metabolite, 20 years, demonstrated that urea effective well-tolerated IH. To reduce daily administration we firstly utilized...
Kaposiform hemangioendothelioma, a rare vascular pediatric tumor often associated with Kasabach-Merritt phenomenon, is characterized by severe thrombocytopenia and consumptive coagulopathy. hemangioendothelioma disease may progress quickly, resulting in high mortality. However, standard treatment regimens for phenomenon have not yet been established. We reported here an infant large congenital kaposiform his chest wall who responded extremely well to surgical excision.
The aim of this study was to investigate the manner urea-modulated UT-B urea transporter (UT) internalization in infantile hemangioma-derived vascular endothelial cells (HemECs). immunohistochemistry assay performed identify infancy cell line (XPTS-1) cells. Cell toxicity detected with 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. Quantitative real-time polymerase chain reaction and Western blot analysis were measured analyze expression UT-B. observed by confocal...
Interventional embolization schedules based on absolute ethanol are usually used for peripheral arteriovenous malformations (PAVMs), and clinicians often choose the scheme according to classification.
Abstract Background Infantile hemangioma is one of the most common benign soft tissue tumors in infants. The pathogenesis infantile remains unclear and twin studies regarding its incidence may help clarify disease pathogenesis. Thus, this study aimed to analyze clinical characteristics patients discuss incidence. Methods We retrospectively analyzed data 83 pairs twins with admitted Guangdong Provincial Women Children Hospital Henan People’s between May 2016 2022. Thirty-one among whom both...
Abstract Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor with high morbidity and mortality. The aim of this study was to evaluate ultrasonographic findings associated KHE. clinical cohort 64 cases pathologically proven KHE were retrospectively reviewed analyzed between November 2014 February 2021. Two subtypes divided according the presence or absence Kasabach-Merritt phenomenon (KMP). KMP risk factors in patients statistically. Among KHE, 43 (67.2%)...
Kasabach-Merritt phenomenon (KMP) is a rare potentially life-threatening consumptive coagulopathy characterized by thrombocytopenia and hypofibrinogenemia occurring associated with the vascular tumors kaposiform hemangioendothelioma (KHE) tufted angioma (TA). KHE in specific sites will also cause some non-hemorrhagic complications. We report two-month old female infant her pelvic cavity, bladder ureter who responded well to surgical excision.