A5005371046- Polyomavirus and related diseases
- Adenosine and Purinergic Signaling
- Herpesvirus Infections and Treatments
- Peptidase Inhibition and Analysis
- Acne and Rosacea Treatments and Effects
- Hematopoietic Stem Cell Transplantation
- Erythropoietin and Anemia Treatment
- Inflammatory mediators and NSAID effects
- Chemical Synthesis and Analysis
- Synthesis of β-Lactam Compounds
- Dental Implant Techniques and Outcomes
- Analytical Chemistry and Chromatography
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Complement system in diseases
- Cervical and Thoracic Myelopathy
- Nonmelanoma Skin Cancer Studies
- Diagnosis and Treatment of Venous Diseases
- Traumatic Brain Injury Research
- Hip and Femur Fractures
- Phosphodiesterase function and regulation
- MicroRNA in disease regulation
- Abdominal Surgery and Complications
- Lung Cancer Treatments and Mutations
- Blood properties and coagulation
- RNA Interference and Gene Delivery
West Cancer Center
2017-2021
University of Missouri–Kansas City
2019
William Carey University
2018
Campbell Clinic
2014
Massachusetts General Hospital
2010
Harvard University
2010
University of St Andrews
2006
State University of New York
1990-1994
Stony Brook University
1990-1994
Wilford Hall Ambulatory Surgical Center
1989-1991
The vascular supply of the femoral head is unique in that its vessels travel along length neck between bone and inelastic capsule, reinforced by iliopsoas muscle. During their course, these are exposed to trauma pressure. high intra-articular pressure created hip joint during certain maneuvers positions used standard treatment suggests that, both fractures diseases hip, an tamponade may obstruct head. Consistent clinical experimental findings have been presented which appear verify this...
We used a Chinese hamster ovary cell line that had been transfected with the human tumor necrosis factor (TNF) gene and constitutively produced TNF when transplanted in nude mice to study effects of continuous production on calcium homeostasis. Continuous exposure caused increased osteoclastic bone resorption humoral hypercalcemia these animals. The bearing TNF-producing tumors were significantly hypercalcuric compared control tumors, but urinary cAMP excretion was unchanged. Mice containing...
The interaction of forskolin with adenylate cyclase was studied by evaluating its effect on metal and metal-ATP kinetics measuring protective when the enzyme subjected to denaturation conditions.The solubilized calmodulin-and forskolin-sensitive from brain particulate platelets were inactivated upon preincubation N-ethylmaleimide.Forskolin protected against this inactivation in a concentration-dependent manner demonstrated Kd values 6.3 7.6 PM for platelet cyclases, respectively.Protection...
The xanthines currently represent the most potent class of adenosine receptor antagonists. However, known derivatives xanthine show little difference in antagonist potency between two putative subtypes, A1 and A2. We conducted a systematic study structure-activity relationships that compared at adipocytes with A2 platelets. Since receptors are coupled to adenylate cyclase these tissues, inhibition via stimulation were used as models activation. Antagonist was quantitated by Schild analysis,...
Abstract Inhibition of adenylyl cyclases from Bacillus anthrasis and Bordetella pertussis by polyadenylate the most potent P-site agonists was investigated. These bacterial differed in their sensitivity to inhibition nominal agents effect divalent cations on this inhibition. The enzyme relatively insensitive agonists, exhibiting a rank order potency 2'd3'AMP greater than 3'-AMP 2',5'-ddAdo approximately Ado 2'-dAdo, with IC50 values for 1-3 mM. 2'd3'AMP, however, not affected cation, making...
Thirty-four children with presumptive acute osteomyelitis or septic arthritis underwent early gallium-67 citrate scintigraphy and have been retrospectively reviewed. Diagnostic accuracy using this technique was 91%. Gallium-67 is a more reliable radiopharmaceutical agent for the detection of selected musculoskeletal infections than either technetium methylene diphosphonate indium-111. However, radiation dosage from gallium higher other agents, authors would recommend its use only in cases...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes disease 2019 (COVID-19), has been demonstrated to be able activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable complement-mediated cell damage. We report a case of patient who presented fatigue, facial swelling, and upper infection (URI) symptoms was found have COVID-19 laboratory tests showing severe...
e19501 Background: Rituximab has improved outcomes in B-cell NHL though early complications, such as gastric perforation have been reported (median time to event 6 days). Methods: Using case listing session of SEER 18 (1973-2010) we examined the impact approval rituximab (1997 and previous v 1998 beyond) on NHL, including risk death (less than 60 Analyses were conducted with SEER*Stat 8.1.2, Microsoft Excel 2007 GraphPadPrism 6. Comparisons made using chi-squared test log rank (Mantel-Cox);...
Systemic immunosuppression in solid organ transplant recipients (SOTR) is associated with increased risk of skin cancer individuals significant prior photoaging (dermatoheliosis). Risk factors for UVR-associated include Fitzpatrick phototype (SPT) 1 to III, age at time transplanation, (duration, intensity, type), UVR exposure, history transplantation, CD4 lymphopenia. Squamous cell carcinoma (SCC) SOTR accounts 90% cancers this population, often more aggressive than the general has a higher...