A5027282756- Nitric Oxide and Endothelin Effects
- Cardiac and Coronary Surgery Techniques
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Renin-Angiotensin System Studies
- Cardiac Arrhythmias and Treatments
- Cancer Genomics and Diagnostics
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Hormonal Regulation and Hypertension
- Breast Cancer Treatment Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Pericarditis and Cardiac Tamponade
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Cardiac Structural Anomalies and Repair
- Intensive Care Unit Cognitive Disorders
Atlantic University College
2024
Florida Atlantic University
2024
OSF HealthCare
2023
University Hospital Southampton NHS Foundation Trust
2017-2021
Information Technology University
2021
NIHR Southampton Biomedical Research Centre
2017
Federal Council
2017
Mayo Clinic in Arizona
1996-2009
Mayo Clinic
1997-2006
Inova Alexandria Hospital
2001-2006
BACKGROUND: Vitamin K antagonists are the only oral anticoagulants approved to prevent valve thrombosis and valve-related thromboembolism in patients with mechanical heart valves. Whether an On-X aortic can be safely anticoagulated apixaban is unknown. METHODS: Patients implanted at least 3 months before enrollment were randomly assigned receive 5 mg twice daily or warfarin (target international normalized ratio 2.0 3.0). The primary efficacy end point was composite of coprimary analyses...
'Big data' in healthcare encompass measurements collated from multiple sources with various degrees of data quality. These require quality control assessment to optimise for clinical management and robust large-scale analysis research. Height weight represent one the most abundantly recorded health statistics. The shift electronic recording anthropometric records, has rapidly inflated number measurements. WHO guidelines inform removal population-based extreme outliers but an absence tools...
Proliferation of the intima is an early lesion saphenous vein graft disease. Early patency rates radial artery grafts are acceptable, but little known about their risk intimal hyperplasia.To develop a model hyperplasia, we incubated human veins, internal mammary arteries, and arteries (n=6, 8, 10, respectively) in organ culture with Roswell Park Memorial Institute 1640 (30% serum) for 0, 4, 7, 14 days. Quantitative histological studies were performed, average intimal-to-medial (I/M) ratio...
Direct gene transfer of exogenous nitric oxide synthase, with the subsequent increase in production, could represent a potential therapeutic strategy treatment vascular proliferative disorders. The goal present study was to determine if porcine coronary arteries be transduced an adenoviral vector encoding endothelial synthase (Ad.CMVeNOS) resulting functional expression.Segments right artery were exposed for 1 h at 37 degrees C either replication-deficient adenovirus bovine (Ad.CMVeNOS, 5 x...
Objectives Most patients are unaware they have liver cirrhosis until present with a decompensating event. We therefore aimed to develop and validate an algorithm predict advanced disease (AdvLD) using data widely available in primary care. Design, setting participants Logistic regression was performed on routinely collected blood result from the University Hospital Southampton (UHS) information systems for 16 967 individuals who underwent upper gastrointestinal endoscopy (2005–2016). Data...
Background —Proliferation of the intima is an early lesion saphenous vein graft disease. Early patency rates radial artery grafts are acceptable, but little known about their risk intimal hyperplasia. Methods and Results —To develop a model hyperplasia, we incubated human veins, internal mammary arteries, arteries (n=6, 8, 10, respectively) in organ culture with Rosewell Park Memorial Institute 1640 (30% serum) for 0, 4, 7, 14 days. Quantitative histological studies were performed, average...
To characterize Purkinje activation (PA) patterns, we studied 15 alpha-chloralose-anesthetized dogs. During left ventricular basal or apical pacing, PA was mapped with a row of four to eight multipolar electrodes placed in the wall record and muscle potentials. times increased linearly distance from pacing site (r = 0.8, slope 1.8 +/- 0.15 mm/ms, P < 0.05). With single premature stimulus (S2) delivered site, delay first evident at remote sites (> 50 mm) S1-S2 185 5 (SD) ms, while...
Coronary arteries respond to hypoxia with transient relaxations, which increases coronary blood flow, in part, by release of nitric oxide. We hypothesized that increased expression oxide synthase might further augment vessel relaxation during hypoxia. The present study examined the effect adenovirus-mediated transfer bovine endothelial (eNOS) on hypoxia-induced relaxations canine arteries.Paired segments were exposed vehicle (phosphate-buffered saline albumin) or an adenovirus encoding...