A5103077419- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Law, Economics, and Judicial Systems
- Sepsis Diagnosis and Treatment
- CAR-T cell therapy research
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Dispute Resolution and Class Actions
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
Heidelberg University
2017-2025
German Cancer Research Center
2017-2025
Universidade Federal de Alagoas
2025
University of Lisbon
2011-2023
DKFZ-ZMBH Alliance
2017-2022
Heidelberg Institute for Stem Cell Technology and Experimental Medicine
2017-2022
Lusíada University of Lisbon
2013
United States Congress
2000
Hospital do Coração
2000
Universidade de São Paulo
2000
Previous reports have shown beneficial effects of pentoxifylline (PTX) and hypertonic saline (HS) in the treatment hemorrhagic shock. We compared these solutions to those conventional lactated Ringer's (LR) on bacterial translocation (BT), lung injury total differential cell count bronchoalveolar lavage fluid (BAL) after Rats (280-330 g) were bled a MAP 35 mmHg for 1 h then randomized into 4 groups: LR (3× shed blood); HS (7,5% NaCI, 4mL/kg); LR+PTX (25mg/kg) SHAM (no shock, no treatment)....
Abstract Previous results indicated that miR-146b-5p is downregulated by TAL1, a transcription factor critical for early hematopoiesis frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL) where it has an oncogenic role. Here, we confirmed expression lower TAL1-positive patient samples than other T-ALL cases. Furthermore, T-cells display decreased levels of as compared to normal T-cells, thymocytes and hematopoietic progenitors. MiR-146b-5p silencing enhances the vitro...
Acute myeloid leukemia with complex karyotype (ckAML) is characterized by high genomic complexity, including frequent TP53 mutations and chromothripsis. Genomic rearrangements that reposition active enhancers near proto-oncogenes, leading to their aberrant expression, have not been systematically investigated in AML. To facilitate the discovery of such "enhancer hijacking" events, we developed pyjacker, a computational tool, applied it 39 ckAML samples. Pyjacker identified several enhancer...
// Nádia C. Correia 1 , Alice Melão Vanda Póvoa Leonor Sarmento Marta Gómez de Cedrón 2 Marcos Malumbres Francisco J. Enguita João T. Barata Instituto Medicina Molecular, Faculdade Medicina, Universidade Lisboa, Portugal Cell Division and Cancer Group, Spanish National Research Centre (CNIO), Madrid, Spain Correspondence to: Barata, e-mail: joao_barata@fm.ul.pt Keywords: T-cell acute lymphoblastic leukemia, T-ALL, TAL1, microRNAs,...
Abstract Acute myeloid leukemia (AML) is a very heterogeneous and highly malignant blood cancer. Mutations of the DNA methyltransferase DNMT3A are among most frequent recurrent genetic lesions in AML. The majority -mutant AML patients shows fast relapse poor survival, but also with long survival or long-term remission have been reported. Underlying molecular signatures mechanisms that contribute to these differences only poorly understood not studied detail so far. We applied hierarchical...
Acute myeloid leukemia with complex karyotype (ckAML) is characterized by high genomic complexity, including frequent TP53 mutations and chromothripsis. We hypothesized that the numerous rearrangements could reposition active enhancers near proto-oncogenes, leading to their aberrant expression. developed pyjacker, a computational tool for detection of enhancer hijacking events, applied it cohort 39 ckAML samples. Pyjacker identified motor neuron pancreas homeobox 1 (MNX1), gene aberrantly...
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. has been implicated cancer, either suppressing or promoting tumor development depending on the tissue. However, impact of hematological tumors remains unknown. Here, we show that T-cell oncogenic TAL1 direct positive regulator CASZ1, acute lymphoblastic leukemia (T-ALL) samples at diagnosis overexpress CASZ1b isoform, expression patient correlates with PI3KAKT- mTOR...
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of relapse and mortality. Current chemotherapies whilst successful in eradicating blasts, are less effective eliminating relapse-causing leukemic stem cells (LSCs). Although LSCs usually identified as CD34+CD38- cells, there significant heterogeneity surface marker expression, CD34- exist particularly NPM1mut AMLs. By analyzing diagnostic primary DNMT3AmutNPM1mut AML samples, we suggest novel flow cytometry...
Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: Myeloid Leukemia (AML) is a highly aggressive adult with high incidence of relapse and mortality. AML hijacked the hierarchical organization normal hematopoiesis Stem Cells (LSCs) at top differentiation tree differentiated proliferating blast bottom. Similar to hematopoietic stem cells (HSCs), LSCs have been originally identified as CD34+CD38- cells. However, this strategy isolate particularly challenging in NPM1...