A5006432675- Neuroendocrine Tumor Research Advances
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- IgG4-Related and Inflammatory Diseases
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Foreign Body Medical Cases
- Congenital gastrointestinal and neural anomalies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Caveolin-1 and cellular processes
- Pediatric Hepatobiliary Diseases and Treatments
- Gastroesophageal reflux and treatments
- Peptidase Inhibition and Analysis
University of Occupational and Environmental Health Japan
2018-2025
Kyushu Rosai Hospital
2023-2025
Uji Hospital
2021-2022
A 66‐year‐old man was admitted to our department due cholestatic liver injury. He had received five cycles of pembrolizumab for small‐cell lung cancer. Imaging showed the possibility sclerosing cholangitis (SC) with hemobilia. Histologically, CD8 + T cells infiltrated biliary epithelium extrahepatic bile duct. We reached diagnosis secondary SC induced by pembrolizumab. Although we treated him high‐dose corticosteroids, laboratory data only a moderate response. Clinicians should recognize...
A 73-year-old man visited our hospital due to hyperintestinal peristalsis and diarrhea. He had been undergoing regular annual checkups for dust lung disease. Contrast-enhanced computed tomography scan showed edematous thickening of the rectal wall with contrast effect. colonoscopy revealed a submucosal tumor-like protrusion in Rb lesion rectum without neoplastic epithelial changes. Forceps biopsies overlying mucosa were non-diagnostic; however, endoscopic ultrasound-guided fine needle biopsy...
A 72-year-old woman with advanced lung cancer had received systemic chemotherapy including atezolizumab. About three months after the initial administration of atezolizumab, her liver enzyme levels increased. The histopathological findings biopsy revealed acute inflammatory infiltrate, predominantly CD3+, CD4+ and CD8+ T lymphocytes, in hepatic lobules. We diagnosed atezolizumab-induced immune-related hepatitis. Oral corticosteroid therapy successfully improved elevation serum...
A liver cyst is hepatic fluid-filled cavities often detected in clinical surveillances such as a health examination. Although the usually asymptomatic and observed without any therapeutic intervention, it can be symptomatic needs treatment due to its enlargement, hemorrhage, infection. 74-year-old woman presented with upper abdominal pain huge left lobe. Several examinations including image findings revealed that symptom could derived from cyst. there no definite guideline of for cysts,...
A 70-year-old man was referred to our department for the treatment of early gastric cancer. Contrast-enhanced computed tomography (CT) incidentally showed diffuse enlargement pancreas with a capsule-like rim, and blood tests elevated serum IgG4 levels, leading diagnosis autoimmune pancreatitis (AIP). Endoscopic cancer performed, pathological findings adenocarcinoma abundant IgG4-positive plasma cell infiltration. Thereafter, levels normalized, AIP disappeared on CT without steroid treatment....
A 52-year-old woman developed vomiting and disturbance of consciousness after consuming raw fish sushi on a trip. blood test showed hyperammonemia (310 μg/dL) with normal liver function. She fell into deep coma, her serum ammonia level increased to 684 μg/dL. L-arginine was administered as diagnostic treatment for urea cycle disorder (UCD) ammonia, levels improved. diagnosed ornithine transcarbamylase deficiency (OTCD) by analyses plasma amino acids, urinary orotic acid, the OTC gene...
An 82-year-old man had been treated for lung adenocarcinoma and hepatocellular carcinoma (HCC). Contrast-enhanced computed tomography examination showed swelling of the left adrenal gland, suggesting metastasis adenocarcinoma, HCC, or primary tumor. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) was performed pathological diagnosis, HCC diagnosed. No notable complications due to EUS-FNA were found. There have reports various cancers, but there are few that can confirm...
The characteristics of liver dysfunction due to adult-onset Still's disease are not specific. Differentiating from autoimmune hepatitis is important in deciding whether continue corticosteroid therapy, and also terms management cirrhosis surveillance hepatocellular carcinoma. Liver biopsy thought be the most determinant for differential diagnosis.
A 69-year-old man was diagnosed with a liver abscess and received antibiotics at local hospital. He referred to our hospital due persistent fever. had hepatic masses protruding from the surface toward transverse colon. We reached diagnosis of inflammatory pseudotumor (IPT) by percutaneous biopsy. Colonoscopy showed direct invasion IPT His condition improved intravenous administration antibiotics. Hepatic is often misdiagnosed as malignant tumor. should consider when we encounter tumors,...
Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy classified inflammatory type immunohistochemical staining. Considering the risk malignant transformation, they underwent surgical resection. Although serum levels protein induced vitamin K absence/antagonist-II (PIVKA-II) slightly elevated, normalized after diagnosis HCA including transformation is often...
Objectives Esophageal variceal bleeding can be fatal in patients with liver cirrhosis. The aim of this study was to investigate the relationship between gastroesophageal flap valve (GEFV) and esophageal bleeding. Methods Subjects were cirrhotic endoscopically diagnosed varices treated at our hospital 2005 2019, excluding those F3 form red color (RC) signs first endoscopy. Sixty‐five normal GEFV (Hill grade I or II) 42 abnormal III IV) enrolled. Propensity score matching eliminated baseline...
An 83-year-old man underwent transcatheter arterial chemoembolization (TACE) for a 20-mm hepatocellular carcinoma (HCC) in Couinaud's segment 4. Computed tomography (CT) 4 months after TACE showed tumor thrombus the portal vein addition to diffuse metastases and arterioportal shunts left lobe. Although we performed best supportive care, tumors lobe had completely disappeared on CT 16 TACE. Rapidly grown shunt might be causes of spontaneous regression HCC, probably associated with hypoxia.
Recurrent biliary obstruction (RBO) after self-expandable metallic stent (SEMS) insertion is a big problem in patients with unresectable malignant (MBO). Sarcopenia associated poor prognosis malignancies. The purpose of this study to clarify the relationship between RBO and sarcopenia.Forty-six normal psoas muscle mass index (PMI) 55 low PMI were enrolled, based on cut-off values. We analyzed cumulative incidences predictors RBO, considering death without be competing risk.In Kaplan-Meier...
A 75-year-old man visited our hospital for the examination of a tumor in pancreas. Computed tomography showed an 85×85-mm low-density The was pathologically diagnosed as poorly differentiated carcinoma by endoscopic ultrasound-guided fine-needle aspiration. Although we started chemotherapy, patient died 84 days after diagnosis. An autopsy demonstrated ruptured anaplastic with mucoepidermoid Anaplastic is very rare histologic subtype pancreatic carcinoma, so pathological findings are...
CASE REPORT A 69-year-old man underwent endoscopic retrograde cholangiopancreatography to remove a common bile duct stone. The trainee initially inserted the TJF-Q290V duodenoscope from Olympus, Japan, with patient in inverse-alpha position (Figure 1). was pulled, and then loop shrank When continuing pull modify loop, tip of migrated esophagus became stuck (Figures 1 2). We decided not perform forcible control since it is associated either perforation or esophageal dissection.1,2 nasal...
症例は65歳の男性．59歳より肝細胞癌に対して肝動脈化学塞栓療法（TACE）とラジオ波焼灼療法で治療していた．62歳時に門脈血栓症に対しワルファリンカリウムの内服を開始したためprotein induced by vitamin K absence or antagonist-II（PIVKA-II）は測定しなかった．64歳時の5月に肝S7に13 mm大，肝S8に12 mm大の肝細胞癌の再発を認めTACEを施行し，その後再発なく経過した．同年11月に腹部造影CTにて肝右葉（S5-6）に造影効果のない辺縁不明瞭な30 mm大の低吸収域を認めた．ワルファリンカリウムをエドキサバンに変更しPIVKA-IIを測定したところ，952 mAU/mLと高値を示した．PET-CTで同部位に集積亢進を認め，肝細胞癌の再発と診断し，低分化型肝細胞癌が比較的急速に進行したものと考えた．肝細胞癌の患者では，α-フェトプロテインとPIVKA-IIが腫瘍の進行の指標となるため，直接経口抗凝固薬の使用が望ましいと考えられた．
Differentiating autoimmune hepatitis from liver dysfunction due to adult-onset Still’s disease is important in deciding whether terminate or continue corticosteroid therapy, and also terms of management cirrhosis surveillance hepatocellular carcinoma. Liver biopsy thought be the most determinant for differential diagnosis.
A 77-year-old woman was referred for severe constipation and abdominal distension which had lasted 1 month. computed tomography (CT) scan a colonoscopy revealed segmental stricture in the transverse descending colons. After no improvement her symptoms observed with conservative therapy, we performed left hemicolectomy. Histopathological examination reduction ganglion cells Meissner's Auerbach's plexuses hypoganglionosis diagnosed. In addition, diagnosis of acquired made because this case...
Pancreatic neuroendocrine carcinoma (NEC) as classified in the World Health Organization (WHO) 2010 was reclassified WHO 2017 either tumor (NET) G3 or NEC. An accurate diagnosis based on classification is important order treating this disease appropriately. We report a case diagnosed NET that responded remarkably well to treatment with streptozocin. The patient would likely not have received streptozocin if she had been reasonable for of advanced pancreatic neoplasms.