A5031909732- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Iron Metabolism and Disorders
- Heavy Metal Exposure and Toxicity
- Cancer, Lipids, and Metabolism
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- IgG4-Related and Inflammatory Diseases
- Cannabis and Cannabinoid Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Tryptophan and brain disorders
- Hemoglobinopathies and Related Disorders
- Nutrition and Health in Aging
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Stress Responses and Cortisol
University of Occupational and Environmental Health Japan
2016-2025
Yokohama Municipal Citizen's Hospital
2022
The University of Kitakyushu
2015
Hepatocellular carcinoma (HCC) develops even in patients with hepatitis C virus (HCV) eradication by direct-acting antiviral agents. Fatty liver and metabolic dysfunction are becoming major etiologies of HCC. We aimed to evaluate the impact dysfunction-associated steatotic disease (MASLD), a new definition disease, on development HCC after HCV eradication.
A 66‐year‐old man was admitted to our department due cholestatic liver injury. He had received five cycles of pembrolizumab for small‐cell lung cancer. Imaging showed the possibility sclerosing cholangitis (SC) with hemobilia. Histologically, CD8 + T cells infiltrated biliary epithelium extrahepatic bile duct. We reached diagnosis secondary SC induced by pembrolizumab. Although we treated him high‐dose corticosteroids, laboratory data only a moderate response. Clinicians should recognize...
Abstract Background Previous studies have suggested an association between the use of direct‐acting antiviral agents (DAAs) for treating hepatitis C virus (HCV) infection and resulting decrease in incidence hepatocellular carcinoma (HCC); however, it is unclear whether DAAs prevent recurrence HCC after curative treatment HCC. This study aimed to prospectively investigate its predictors Methods A total 3012 patients with chronic HCV infection, or without cirrhosis, who were treated enrolled...
Aims: Antiplatelet therapy has been reported to reduce liver fibrosis and hepatocellular carcinoma (HCC), exhibited antitumor properties in other cancers. However, the effects of antiplatelet after diagnosis HCC are unknown. We investigated on prognosis, tumor progression, function safety patients. Methods: retrospectively analyzed 772 was defined as regular intake aspirin or clopidogrel from through an endpoint either overall survival (OS) liver-related death. Overall survival, death,...
Abscesses associated with gallbladder perforation are often confined to the peri-gallbladder region. We herein report a rare case of in which abscess cavity extended into left upper quadrant. A 79-year-old woman developed secondary acalculous cholecystitis. Computed tomography revealed fluid collection extending from dorsal hepatic lobe contact stomach. successfully treated percutaneous transhepatic drainage and simultaneous endoscopic ultrasound-guided transgastric internal external...
Abstract Transcatheter arterial chemoembolization (TACE) is a standard treatment for intermediate-stage hepatocellular carcinoma (HCC). However, TACE can cause deterioration of liver functions. We aimed to identify the factors that influence function after TACE. retrospectively analyzed 262 patients who underwent as initial HCC with Child–Pugh grade A. divided them into three groups stratified by etiology underlying disease. Patients were classified hepatitis B virus (HBV) group, C (HCV) and...
Abstract Background Major depressive disorder (MDD) is strongly associated with type 2 diabetes mellitus (T2DM). The kynurenine and serotonin pathways, as well chronic low-grade inflammation, are being considered potential links between them. MDD T2DM less responsive to antidepressants than that without T2DM; however, the underlying mechanism remains unknown. Aims & Objectives We aimed investigate effects of inflammatory cytokines on pathways in patients comorbid those only MDD. Method...
Background/Objectives: Durvalumab plus Tremelimumab (Dur/Tre) therapy is expected to have good therapeutic efficacy for patients with advanced hepatocellular carcinoma (HCC). However, the predictors of clinical response and prognosis not been established. Here, we retrospectively investigated Dur/Tre therapy. Methods: This retrospective single-center study, which included 30 patients, aimed evaluate treatment HCC. Factors associated an objective rate (ORR), progression-free survival (PFS),...
Long-chain fatty acyl CoA synthetase 4 (ACSL4) is crucial for lipid metabolism, primarily catalyzing the formation of 12-20 carbon chain acids. ACSL4 upregulated in various cancers and linked to aggressive behavior poor survival. A bioinformatics study showing upregulation pancreatic cancer. However, utility actual pathological diagnosis clinical significance ductal adenocarcinoma (PDAC) intraductal papillary mucinous neoplasm (IPMN) are unexplored. This aimed investigate expression PDAC...
Abstract Aim This study aimed to evaluate the efficacy of durvalumab + tremelimumab (Dur Tre) in real‐world clinical practice, characterize “stable disease (SD),” and identify SD responders (SD‐R) who benefit from Dur Tre treatment. Methods multicenter observational included 212 patients with unresectable hepatocellular carcinoma (u‐HCC) treated between March 2023 November 2024. The were categorized into 95 first‐line 117 later‐line cases, respectively. Sequential cutoff points for depth...
Endoplasmic reticulum stress is associated with the pathophysiology of various liver diseases. mediates accumulation abnormal proteins and leads to oxidative stress, cytoplasmic inclusion body formation, apoptosis in hepatocytes. Autophagy a bulk degradation pathway for long-lived or damaged organelles also major many aggregate-prone disease-causing proteins. We previously reported that rapamycin, mammalian target rapamycin inhibitor, activated autophagy decreased proteasome...
A 72-year-old woman with advanced lung cancer had received systemic chemotherapy including atezolizumab. About three months after the initial administration of atezolizumab, her liver enzyme levels increased. The histopathological findings biopsy revealed acute inflammatory infiltrate, predominantly CD3+, CD4+ and CD8+ T lymphocytes, in hepatic lobules. We diagnosed atezolizumab-induced immune-related hepatitis. Oral corticosteroid therapy successfully improved elevation serum...
A 37-year-old man was diagnosed with Wilson disease at the age of 14. His first manifestations were neurological. He treated trientine for more than 10 years and suffered from anemia liver dysfunction. is a genetic disorder characterized by accumulation copper in body. Excess toxic, but an essential trace element. Copper-binding ceruloplasmin important iron metabolism. chelating treatment-induced deposition suspected. Proper monitoring status management disease.
A 68-year-old man with occult hepatitis B virus (HBV) infection was diagnosed malignant lymphoma and achieved complete remission after treatment a chemotherapy regimen including rituximab for 5 months. Entecavir (ETV) also used during ended at 14 months chemotherapy. However, reactivation of HBV observed in blood tests, which showed not only elevation HBV-DNA but HBsAg HBeAg, 27 the end After restarting ETV, levels immediately subsided. In addition, anti-HBs became remained positive 31 ETV...
Lenvatinib has become a first line treatment for unresectable hepatocellular carcinoma (HCC). However, continued administration is impossible in many patients due to resistance and severe adverse events. This study aimed identify predicting factors select likely benefit from lenvatinib treatment.We retrospectively analyzed 53 who were treated with HCC. They divided two groups; low C-reactive protein (CRP) group pretreatment serum CRP level < 1.0 mg/dL high ≥ mg/dl. Overall survival (OS),...
Zinc is an essential trace element and plays critical roles in cellular integrity biological functions. Excess copper induced both oxidative stress endoplasmic reticulum (ER) liver-derived cultured cells. also impairment of autophagic flux at the step autophagosome–lysosome fusion, as well Mallory–Denk body (MDB)-like inclusion formation. ameliorated excess copper-induced MDB-like formation via maintenance ER homeostasis. Furthermore, zinc free fatty acid-induced flux. These results indicate...
Background: A close relationship exists between major depressive disorder (MDD) and diabetes mellitus. The metabolomic difference similarity patients with without mellitus have not been well studied in the context of MDD. We aimed to examine these differences common serum metabolomics patterns, pathways biomarkers that can comprehensively reflect pathogenetic MDD groups. Methods: performed a analysis samples healthy controls (n = 6), type 2 13), 27). Metabolomics was conducted using...
A 78-year-old man presented with cutaneous blisters of the limbs and abdominal distension. He had been treated for various diseases, including liver cirrhosis. begun receiving sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, diabetes mellitus three years before hospitalization. skin biopsy demonstrated bullous pemphigoid. Ultrasonography (US) revealed multiple tumors, although he regular US studies. We stopped sitagliptin started insulin corticosteroids. However, his renal...