A5078945617- Neonatal Respiratory Health Research
- Barrier Structure and Function Studies
- Genetics and Neurodevelopmental Disorders
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
- Neurogenesis and neuroplasticity mechanisms
Goethe University Frankfurt
2017-2020
Maintenance of the endothelial blood-brain-barrier (BBB) through Wnt/β-catenin signalling is essential for neuronal function. The cells however, providing Wnt growth factors at adult neurovascular unit (NVU) are poorly explored. Here we show by conditionally knocking out evenness interrupted (Evi) gene in astrocytes (EviΔAC) that astrocytic release crucial BBB and NVU integrity. EviΔAC mice developed brain oedema increased vascular tracer leakage. While vascularization junctions were not...
The dentate gyrus (DG) is a unique structure of the hippocampus that distinguished by ongoing neurogenesis throughout lifetime an organism. development DG, which begins during late gestation and continues postnatal period, comprises structural formation DG as well establishment adult neurogenic niche in subgranular zone (SGZ). We investigated time course maturation male C57BL/6J mice Sprague Dawley rats based on distribution patterns immature neuronal marker doublecortin (DCX) for mature...