A5056370487- Barrier Structure and Function Studies
- Speech Recognition and Synthesis
- Phonetics and Phonology Research
- MicroRNA in disease regulation
- Linguistic Studies and Language Acquisition
- Extracellular vesicles in disease
- Caveolin-1 and cellular processes
- Voice and Speech Disorders
- Infectious Encephalopathies and Encephalitis
- Neurological Disease Mechanisms and Treatments
- Speech and Audio Processing
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Speech and dialogue systems
- RNA regulation and disease
- Microbial bioremediation and biosurfactants
- Cytomegalovirus and herpesvirus research
- S100 Proteins and Annexins
- Fetal and Pediatric Neurological Disorders
- RNA Research and Splicing
- Chronic Kidney Disease and Diabetes
- Pulmonary Hypertension Research and Treatments
- Ion Transport and Channel Regulation
- Bacterial Infections and Vaccines
- Natural Language Processing Techniques
GenXPro (Germany)
2018-2024
Goethe University Frankfurt
2020-2021
University of Kentucky
2019
University of Bari Aldo Moro
2019
University of Copenhagen
2019
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento
2017
University of Lisbon
2017
Universidade Estadual de Campinas (UNICAMP)
1998
Maintenance of the endothelial blood-brain-barrier (BBB) through Wnt/β-catenin signalling is essential for neuronal function. The cells however, providing Wnt growth factors at adult neurovascular unit (NVU) are poorly explored. Here we show by conditionally knocking out evenness interrupted (Evi) gene in astrocytes (EviΔAC) that astrocytic release crucial BBB and NVU integrity. EviΔAC mice developed brain oedema increased vascular tracer leakage. While vascularization junctions were not...
Microfluidic lab-on-a-chip (LOC) devices allow the study of blood-brain barrier (BBB) properties in dynamic conditions. We studied a BBB model, consisting human endothelial cells derived from hematopoietic stem co-culture with brain pericytes, an LOC device to fluid flow regulation endothelial, and glycocalyx-related genes surface charge. The highly negatively charged glycocalyx functions as mechano-sensor detecting shear forces generated by blood on luminal side contributes physical BBB....
Abstract Formation, maintenance, and repair of the blood–brain barrier (BBB) are critical for central nervous system homeostasis. The interaction endothelial cells (ECs) with brain pericytes is known to induce BBB characteristics in ECs during embryogenesis can be used differentiate human from stem cell source vitro models. However, molecular events involved maturation not fully understood. To this end, derived hematopoietic were cultivated either primary bovine or line-derived formation....
Blood–brain barrier (BBB) models derived from human stem cells are powerful tools to improve our understanding of cerebrovascular diseases and facilitate drug development for the brain. Yet providing cell–derived endothelial with right signaling cues acquire BBB characteristics while also retaining their vascular identity remains challenging. Here, we show that simultaneous activation cyclic AMP Wnt/β-catenin inhibition TGF-β pathway in robustly induce properties vitro. To target this...
Extracellular vesicles are released by numerous cell types of the human body under physiological but also pathophysiological conditions. They important for cell-cell communication and carry specific signatures peptides RNAs. In this study, we aimed to determine whether extracellular isolated from patients with pulmonary hypertension show a disease signature small non-coding RNAs thus have potential serve as diagnostic prognostic biomarkers. were serum 23 chronic thromboembolic (CTEPH)...
Consideration of the many kidnapping cases in Brazil has led to conclusion that criminals sometimes try disguise their voices by speaking with a pen or pencil between from teeth, condition which places it perpendicular line sagittal plane. These settings interact among themselves and also speaker's basic articulatory setting yielding acoustic effects are not easy interpret. This is because different speech segments will be affected differing degrees, depending on greater lesser...
Bacterial and Archaeal communities have a complex, symbiotic role in crude oil bioremediation. Their biosurfactants degradation enzymes been the spotlight, mainly due to awareness of ecosystem pollution caused by accidents their use. Initially, scientific community studied individual microbial species characterizing optimizing biosurfactant genes, studying distribution. However, with advances genomics, particular use New-Generation-Sequencing Metagenomics, it is now possible macro view...
Echovirus-30 (E-30) is responsible for the extensive global outbreaks of meningitis in children. To gain access to central nervous system, E-30 first has cross epithelial blood–cerebrospinal fluid barrier. Several causing bacteria preferentially infect human choroid plexus papilloma (HIBCPP) cells a polar fashion from basolateral cell side. Here, we investigated infection HIBCPP with E-30. Both apical and infections caused significant decrease transepithelial electrical resistance cells....
Echovirus-30 (E-30) is a non-polio enterovirus responsible for meningitis outbreaks in children worldwide. To gain access to the central nervous system (CNS), E-30 first has cross blood-brain barrier (BBB) or blood-cerebrospinal fluid (BCSFB). may use lipid rafts of host cells interact with and invade BCSFB. study enteroviral infection BCSFB, an established vitro model based on human immortalized brain choroid plexus papilloma (HIBCPP) been used. Here, we investigated impact protein content...
Abstract Blood-brain barrier (BBB) models derived from human stem cells are powerful tools to improve our understanding of cerebrovascular diseases and facilitate drug development for the brain. Yet providing cell-derived endothelial with right signaling cues acquire BBB characteristics while also retaining their vascular identity remains challenging. Here, we show that simultaneous activation cyclic AMP Wnt/β-catenin signaling, inhibition TGF-β pathway in robustly induce properties vitro ....
enhanced cholesterol efflux capacity and may underline the improved HDL functionality after RYGB.Reduced sphingosine-1-phosphate (S1P) content is a known mediator of dysfunction.Indeed, S1P was also increased in small HDL-1Y RYGB.Total concentration post RYGB.Conclusions: Small RYGB are have capacity.Elevated PC, PS, PA their lyso-forms as well levels contribute to athero-protective function RYGB.RYGB seems achieve dual benefit increasing HDL.
Discoveries leading to an improved understanding of immune surveillance the central nervous system (CNS) have repeatedly provoked dismissal existence privilege CNS.Recent rediscoveries lymphatic vessels within dura mater surrounding brain by modern live cell imaging technologies revived this discussion.Understanding CNS requires intimate knowledge its unique anatomy.Employing in vivo and vitro studies on migration into during neuroinflammation using we explored anatomical routes cellular...
Various techniques for experimental speech signal manipulation to test recognition of familiar voices have been used, but random spliced (RSS) has not tried. This procedure, which consists randomly recombining digitally segmented signals, offers the advantage more natural-sounding and decreased risk creating artifacts interfering with perception. Although intelligibility is also destroyed by this technique, RSS preserves spectral cues related voice quality, as well F0 level range. In present...