A5013718412- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Hematopoietic Stem Cell Transplantation
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chromosomal and Genetic Variations
- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Complement system in diseases
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Genomics and Chromatin Dynamics
- Heparin-Induced Thrombocytopenia and Thrombosis
Centre International de Recherche en Infectiologie
2022-2025
Inserm
2018-2025
Hôpital Lyon Sud
2015-2025
Centre National de la Recherche Scientifique
2019-2025
École Normale Supérieure de Lyon
2022-2025
Université Claude Bernard Lyon 1
2018-2025
Hospices Civils de Lyon
2018-2025
Centre de Recherche en Cancérologie de Lyon
2018-2024
Centre Léon Bérard
2017-2024
Centro de Investigación del Cáncer
2024
Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may tumor antigens relevant for cancer immunotherapy. We developed a bioinformatic approach to identify shared CD8 + T cell epitopes derived from cancer-associated HERVs in solid tumors. Six candidates among most commonly HLA-A2 with evidence translation were selected immunological evaluation. In vitro priming assays confirmed immunogenicity these epitopes, which induced high-avidity clones. These cells...
BackgroundAcute leukaemias are life-threatening haematological cancers characterised by the infiltration of transformed immature haematopoietic cells in blood and bone marrow. Prompt accurate diagnosis three main acute leukaemia subtypes (ie lymphocytic [ALL], myeloid [AML], promyelocytic [APL]) is utmost importance to guide initial treatment prevent early mortality but requires cytological expertise that not always available. We aimed benchmark different machine-learning strategies using a...
Background Acute myeloid leukemia (AML) remains a very difficult disease to cure due the persistence of leukemic stem cells (LSCs), which are resistant different lines chemotherapy and basis refractory/relapsed (R/R) in 80% patients with AML not receiving allogeneic transplantation. Methods In this study, we showed that interleukin-1 receptor accessory protein (IL-1RAP) is overexpressed on cell surface LSCs all subtypes confirmed it as an interesting promising target compared most common...
Class I Human Leukocyte Antigen (HLA) evolutionary divergence (HED) is a metric which reflects immunopeptidome diversity and has been associated with immune checkpoint inhibitor responses in solid tumors. Its impact interest allogeneic hematopoietic stem cell transplantation (HCT) have not yet thoroughly studied. This study analyzed the clinical of class II HED 492 acute myeloid leukemia (AML) recipients undergoing HCT. The overall cohort was divided into training (n=338) testing (n=132)...
Beyond their critical role in hemostasis, platelets physically interact with neutrophils to form neutrophil-platelet aggregates (NPAs), enhancing neutrophil effector functions during inflammation. NPAs may also promote disease worsening various inflammatory diseases. However, characterization of cancer remains totally unexplored. Using ImageStreamX (ISX) imaging flow cytometer, we were not only allowed able detect CD15+ CD14- CD36+ ITGA2B+ both healthy donors' (HDs) and patients' bloods, but...
Abstract Human endogenous retroviruses (HERVs) represent 8% of the human genome. The expression HERVs and their immune impact have not been extensively studied in Acute Myeloid Leukemia (AML). In this study, we used a reference 14 968 HERV functional units to provide thorough analysis normal AML bone marrow cells. We show that retrotranscriptome accurately characterizes leukemic cell subpopulations, including leukemia stem cells, line with different epigenetic profiles. then delineates...
Chimeric antigen receptor (CAR) T cell therapy represents a major breakthrough in the field of immuno-oncology. Many potential issues are apparent for autologous CAR therapy, such as time manufacturing and need interim therapies progressing patients, wide variations terms quality quantity cells, difficulty to obtain enough cells redosing. "Off-the-shelf" allogeneic premanufactured from third-party donors may theoretically provide solutions these different problems. However, possess foreign...
Immune reconstitution (IR) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently monitored by measuring the absolute number of immune effectors. However, this approach does not capture functional capacities. In study, we aimed to evaluate temporal evolution IR alongside traditional counts measurements. Whole-blood stimulation with TruCulture® tubes containing lipopolysaccharides or Staphylococcal enterotoxin B was performed on 55 allo-HSCT recipients at 6- and...
Data analysis is a crucial step in every research project life science.Every clinician or researcher one day faced with the need to perform statistical analysis.However, few free accessible solutions exist date and most of relevant software programs paid license.R language which allows (R Core Team, 2017).While R environment very powerful, its learning curve can be steep beginning, especially for people no previous coding skills those less time learn them.A graphical user interface has...
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Abstract Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) provide transient responses, failing to eradicate malignant clone. Hematopoietic stem cell (HSC) aging involves heterochromatin reorganization, evidenced by alterations in histone marks H3K9me2 and H3K9me3. These repressive together with methylation essential suppressing transposable elements (TEs). In solid...