A5002909169- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Optical Sensing Technologies
- Spectroscopy and Chemometric Analyses
- Digital Holography and Microscopy
- Optical measurement and interference techniques
- Advanced Vision and Imaging
- Fluid Dynamics and Turbulent Flows
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Pulmonary Hypertension Research and Treatments
- Mitochondrial Function and Pathology
- Brain Tumor Detection and Classification
- Nitric Oxide and Endothelin Effects
- Advanced Image Processing Techniques
- Prostate Cancer Treatment and Research
- Hemoglobin structure and function
- High Altitude and Hypoxia
- Winter Sports Injuries and Performance
- Nanoparticles: synthesis and applications
- ATP Synthase and ATPases Research
- Advanced Nanomaterials in Catalysis
- Aerospace Engineering and Energy Systems
- Water Quality Monitoring and Analysis
- Cardiovascular and exercise physiology
- Laser and Thermal Forming Techniques
Luleå University of Technology
2018-2022
Linköping University
2021
Preprocessing of Raman spectra is generally done in three separate steps: (1) cosmic ray removal, (2) signal smoothing, and (3) baseline subtraction. We show that a convolutional neural network (CNN) can be trained using simulated data to handle all steps one operation. First, synthetic are created by randomly adding peaks, baseline, mixing peaks with background noise, rays. Second, CNN on known peaks. The results from preprocessing were higher quality than what was achieved reference based...
Mitochondria play an important role in sensing both acute and chronic hypoxia the pulmonary vasculature, but their primary oxygen-sensing mechanism contribution to stabilization of hypoxia-inducible factor (HIF) remains elusive. Alteration mitochondrial electron flux increased superoxide release from complex III has been proposed as essential trigger for hypoxic vasoconstriction (HPV). We used mice expressing a tunicate alternative oxidase, AOX, which maintains when respiratory complexes...
Delineating cancer tissue while leaving functional intact is crucial in brain tumor resection. Despite several available aids, surgeons are limited by preoperative or subjective tools. Raman spectroscopy a label-free optical technique with promising indications for identification. To allow direct comparisons between measurements preprocessing of the signal required. There many recognized methods spectra; however, there no universal standard. In this paper, six different were tested on...
Abstract Current optical flow-based neural networks for particle image velocimetry (PIV) are largely trained on synthetic datasets emulating real-world scenarios. While provide greater control and variation than what can be achieved using experimental supervised learning, it requires a deeper understanding of how or factors dictate the learning behaviors deep PIV. In this study, we investigate performance recurrent all-pairs field transforms-PIV (RAFTs-PIV) network, current state-of-the-art...
Abstract The ability to sense changes in oxygen availability is fundamentally important for the survival of all aerobic organisms. However, cellular sensing mechanisms and pathologies remain incompletely understood studies acute sensing, particular, have produced inconsistent results. Current methods cannot simultaneously measure key events hypoxia (i.e., redox state, electrophysiological properties, mechanical responses) at controlled partial pressures (pO 2 ). lack such a comprehensive...
Acute hypoxia changes the redox-state of pulmonary arterial smooth muscle cells (PASMCs). This might influence activity redox-sensitive voltage-gated K⁺-channels (Kv-channels) whose inhibition initiates hypoxic vasoconstriction (HPV). However, molecular mechanism how hypoxia-or subsequent change in cellular redox-state-inhibits Kv-channels remains elusive. For this purpose, a new multifunctional gas-tight microfluidic system was developed enabling simultaneous single-cell Raman spectroscopic...
A bi-directional digital holographic imaging system is presented that designed to take images automatically out in the field. The main objective acquire sufficient information be able estimate scattering phase function for different type of snowfall. consists a 3D-printed frame and two orthogonal telecentric arms, one forward direction side which reference arms are directed along paths. All acquired using pulsed visible light.
• We studied 455 patients (mean age, 51 years) in whom exercise thallium 201 scintigrams performed for suspected coronary artery disease were normal. Of those, 322 (71%) had typical or atypical angina pectoris and 68% achieved 85% more maximal predicted heart rate. The ECGs abnormal 68 (15%), normal 229 (50%), inconclusive 158 (35%). Ventricular arrhythmias occurred during 194 (43%). After a mean follow-up period of 14 months, four cardiac events, sudden death one nonfatal myocardial...
The depth-gating capacity of a spatially quasi-incoherent imaging interferometer is investigated in relation to the 3D correlation properties diffraction field laser speckles. system exploits phase-stepped Michelson-type which illumination generated by passing an unexpanded beam through rotating diffuser. Numerical simulations and optical experiments both verify that scales as λ/2NAp2, where λ wavelength NAp numerical aperture illumination. For set depth gate 150 µm, demonstrated scanning...
We have applied a CNN to preprocess Raman spectra from fresh tissue samples brain tumors. The neural network can handle the variations that occur naturally, which enables explorative data analysis methods such as PCA.
Defocused laser speckle photography is used as a tool to measure the heat responses in titanium component during heating. The evolution of response compared with set preprocessed Finite Element Simulations corresponding process aim verify simulation model and find settings that best resemble experimental results. consists 300 x 100 mm<sub>2</sub> substrate thickness 3.2 mm on which 200 30 11 mm<sup>3</sup> ridge built up using metal deposition by wire process. heated top W for 10 s...
Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to localized alveolar hypoxia that intrinsic the circulation. By hypoxia‐induced contraction of arterial smooth muscle cells (PASMCs), capillary blood flow redirected areas high oxygen partial pressure (pO 2 ), thus maintaining ventilation‐perfusion ratio. Although principle HPV was recognized decades ago underlying pathway still remains elusive. Voltage gated K + ‐channels (K v ‐channels) are known be redox‐sensitive and...
An interferometric technique that utilize a spatially quasi-incoherent light source to perform measurements involving diffusely scattering objects is presented. The proposed demonstrated with settings give depth gate of 90 µm.
Front Cover In article number 2100470, Knoepp, Weissmann, Ramser and co-workers developed a microfluidic device for combined laser-based Raman spectroscopy, Patch-clamp electrophysiology, live cell imaging of single cells under tight oxygen-control. This enables the simultaneous label-free assessment key cellular features underlying mammalian oxygen-sensing processes.
We described a new concept on depth-resolved investigation based imaging interferometry. It exploits quasi-incoherent interferometry scheme and speckle image correlation techniques. can spatially resolve depth-gating capacity of the interferometer with resolution around 26 µm.
We have applied a CNN to preprocess Raman spectra from fresh tissue samples brain tumors. The neural network can handle the variations that occur naturally, which enables explorative data analysis methods such as PCA.