A5044797706- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- T-cell and B-cell Immunology
- Thyroid Cancer Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Helicobacter pylori-related gastroenterology studies
- Hypothalamic control of reproductive hormones
- Ovarian cancer diagnosis and treatment
- Child and Adolescent Health
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- Sexual Differentiation and Disorders
- Vitamin D Research Studies
- Parvovirus B19 Infection Studies
- Air Quality Monitoring and Forecasting
- Vascular Malformations and Hemangiomas
- Galectins and Cancer Biology
- Obesity and Health Practices
- Pediatric Hepatobiliary Diseases and Treatments
- Atmospheric chemistry and aerosols
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Microtubule and mitosis dynamics
Mackay Medical College
2016-2024
Mackay Memorial Hospital
2012-2024
Mackay Junior College of Medicine, Nursing and Management
2011-2022
National Taiwan University
2012
National Chung Hsing University
2006
National Cheng Kung University
2005
Autoimmune thyroid disease (AITD), including Graves (GD) and Hashimoto (HD), is an organ-specific autoimmune with a strong genetic component. Although the cytotoxic T-lymphocyte-associated protein 4 (CTLA4) polymorphism has been reported to be associated AITD in adults, few studies have focused on children. The aim of our study was investigate whether CTLA4 polymorphisms, -318C/T (rs5742909), +49A/G (rs231775), CT60 (rs3087243), were GD HD Han Chinese adults We studied 289 adult GD, 265...
Diabetic ketoacidosis (DKA) is associated with dehydration and which can cause acute kidney injury (AKI). The proportion of AKI in children adolescents DKA has not been reported East Asian population. This study aimed to identify the prevalence determine whether there an association between severity recovery time from metabolic acidosis DKA. Medical records (aged <18 years) presenting type 1 or 2 diabetes mellitus 2000-2017 at MacKay Children's Hospital were retrospectively reviewed. was...
Autoimmune thyroid disease (AITD) is the most common associated autoimmune disorder in type 1 diabetes (T1D). Early detection of AITD crucial to optimize glycemic control, growth, and intellectual development. In this prospective cohort study, we sought characterize prevalence, incident ages risk factors children adolescents with T1D.Patients T1D diagnosed at ≤ 18 years MacKay Children's Hospital, Taipei, from 1990 2019 underwent annual screening for AITD. Institutional Review Board-approved...
BackgroundThe gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for confirming activation of hypothalamic–pituitary–gonadal axis in central precocious puberty (CPP). However, it time-consuming and costly. Our aim was to search a simpler diagnostic modality CPP by 1) evaluating performance basal serum luteinizing (LH), 2) constructing practical scoring system, 3) determining optimal single sampling time LH GnRH test.MethodsData girls aged between 3 9 years at test,...
We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 (IA2A), and insulin (IAA) in 750 children with type 1 diabetes (T1D) living Taiwan. GADA, IA2A, IAA were measured by radioimmunoassay. The data assessed χ2 test, binary logistic regression, Spearman rank correlation. Of T1D patients, 66.3% had 65.3% 35.7% IAA, 17.2% no autoantibodies. GADA IA2A significantly decreased along duration. positivity either or was 89.4% within...
Microalbuminuria and macroalbuminuria are markers of diabetic nephropathy (DN). The purpose this study was to unravel the risk factors for DN in young patients with type 1 diabetes (T1D).341 (160 males) T1D diagnosed at age 7.6 ± 4.0 years disease duration 11.5 6.5 were assessed. Among them, 185 adults (aged 18.0-36.2 years). Urinary albumin creatinine ratio (UACR) checked on morning spot urine. defined as a UACR 30-300 mg/g >300 mg/g, respectively, least 2 consecutive specimens.50 (14.7%)...
Abstract Hashimoto disease ( HD ) is an autoimmune thyroid resulting from complex interactions between genetic and environmental factors. The human leukocyte antigen HLA gene has been established to be involved in the susceptibility . We aim investigate associations ‐B alleles Han Chinese children with by both case‐control family‐based studies. A total of 108 unrelated , 380 healthy controls, 58 trios affected patients their parents, 75 unaffected siblings parents were recruited. genotyping...
BackgroundGraves disease (GD) is the most common cause of thyrotoxicosis in children and adolescents, accounting for 15% all thyroid diseases during childhood. Anti-thyroid drugs (ATD) are recommended as first-line treatment adolescents. However, remission rate lower than adults, optimal duration favorable factors associated with remain unknown. We aimed to investigate long-term outcomes pediatric GD patients receiving ATD.MethodsWe retrospectively reviewed medical charts 396 subjects from...
The long-term impact of Helicobacter pylori infection is complex, and concerns about the need for eradication exist. We conducted this case control study to investigate association between H. failure thrive (FTT).From January 2009 December 2011, 53 children with FTT group matched same sex age similar socioeconomic status without (control group) were enrolled. A questionnaire was administered parents/guardian, a 13C-urea breath test performed detect infection.We found that total prevalence...
An inactivating mutation in the GNAS gene causes either pseudohypoparathyroidism 1a (PHP1A) when it is maternally inherited or pseudopseudohypoparathyroidism (PPHP) paternally inherited. We investigated clinical manifestations and mutations of ethnic Chinese patients with PHP1A PPHP. Seven from 5 families including 4 girls 2 boys 1 girl PPHP were studied. All had mental retardation. They treated calcitriol CaCO3 regular monitoring serum Ca levels, urinary Ca/Cr ratios, renal sonography....
Abstract Graves disease ( GD ) is an autoimmune thyroid with a female preponderance and wide range of ages at onset, human leukocyte antigen HLA gene plays primary role in the susceptibility to . We aim investigate associations between HLA‐DRB1 alleles Taiwanese children by both case‐control family‐based studies. A total 241 unrelated , 539 healthy controls, 115 trios affected patients their parents, 121 unaffected siblings parents were recruited. genotyping was performed polymerase chain...
Poorly differentiated thyroid carcinoma (PDTC) is a rare disease with poor prognosis in children. We describe 9-year-old boy nodule composed of cystic and solid components, which became completely hypoechoic was subsequently proved to be PDTC. The tumor consisted small- intermediate-size round cells trabecular or insular pattern hyperchromatic nuclei mitotic figures. were positive for transcription factor 1 thyroglobulin. PDTC morphologically prognostically between the well-differentiated...
Primary intracranial ependymoma is a challenging tumor to treat despite the availability of multidisciplinary therapeutic modalities, including surgical resection, radiotherapy, and adjuvant chemotherapy. After completion initial treatment, when resistant cells recur, salvage therapy needs be carried out with more precise strategy. Circulating (CTCs) have specifically been detected validated for patients primary or recurrent diffused glioma. The CTC drug screening platform can used perform...
Septo-optic dysplasia (SOD) is a rare congenital disorder that may cause jaundice in infants. However, it usually prone to neglect and misdiagnosis infants with cholestasis because endocrine such as panhypopituitarism the of infantile cholestasis. We report case SOD concurrent acquired cytomegalovirus (CMV) infection, who presented prolonged first clinical sign.The patient was 2-month-old male infant cholestasis, combined fever panhypopituitarism.He diagnosed CMV infection.He treated hormone...
Human Leukocyte Antigen (HLA)-DQ2 and HLA-DQ8 are genetic risk factors for Type 1 Diabetes Mellitus (T1DM) Celiac disease (CD) in Caucasians, but their association with Taiwanese Han population is unknown. We screened 532 T1DM patients CD biomarkers including anti-tissue transglutaminase (TGM2), anti-gliadin anti-neoepitope antibodies (Abs), sequencing DQB1 genotypes, characterized the TGM2 Abs. report that 3.76% of had TGM2-Abs all no CD's symptoms. In contrast to Caucasian's patients,...