A5075875257- Single-cell and spatial transcriptomics
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Sports injuries and prevention
- Spinal Cord Injury Research
- Effects of Vibration on Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Noise Effects and Management
- Sports Performance and Training
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Immune cells in cancer
- Diabetes and associated disorders
- Injury Epidemiology and Prevention
- Cerebral Palsy and Movement Disorders
- Photochemistry and Electron Transfer Studies
- Zebrafish Biomedical Research Applications
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Gene Regulatory Network Analysis
- Musculoskeletal Disorders and Rehabilitation
- Trauma Management and Diagnosis
- Supramolecular Self-Assembly in Materials
University of Oklahoma
1998-2025
École Polytechnique Fédérale de Lausanne
2016-2024
Wyss Center for Bio and Neuroengineering
2023-2024
State Street (United States)
2024
University of Lausanne
2021-2023
Massachusetts General Hospital
2021
University of California, San Francisco
2006-2020
University of Oklahoma Health Sciences Center
2003-2018
University of California, Los Angeles
2012-2018
Tongji University
2016
Astroglial scars surround damaged tissue after trauma, stroke, infection, or autoimmune inflammation in the CNS. They are essential for wound repair, but also interfere with axonal regrowth. A better understanding of cellular mechanisms, regulation, and functions astroglial scar formation is fundamental to developing safe interventions many CNS disorders. We used wild-type transgenic mice quantify dissect these parameters. Adjacent crush spinal cord injury (SCI), reactive astrocytes...
Differential expression analysis in single-cell transcriptomics enables the dissection of cell-type-specific responses to perturbations such as disease, trauma, or experimental manipulations. While many statistical methods are available identify differentially expressed genes, principles that distinguish these and their performance remain unclear. Here, we show relative is contingent on ability account for variation between biological replicates. Methods ignore this inevitable biased prone...
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing identify that restore walking after incomplete SCI. We show chemoattracting guiding the transected...
This study was supported in part by a grant from the Foundation for Physical Therapy, Inc. The purpose of this to compare relationships among isometric, isotonic, and isokinetic concentric eccentric quadriceps hamstring forces three components athletic performance college-aged, male athletes. Bilateral muscle torque were obtained (N = 39) using KinCom(R) (rate at 60 degrees /sec 180 /sec), 30 90 isometric (knee angles ) contractions. Athletic assessed vertical jump performance, 40-yard dash...
Elastic band (EB) training is a common form of resistance used by the elderly, individuals with joint problems or those recovering from injury. EB performed at low intensities these populations may have little effect on muscle hypertrophy. However, when combined blood flow restriction (BFR), low-intensity result in hypertrophy.Postmenopausal women (61 ± 5 years) were assigned to moderate-to-high-intensity group (MH, n = 8) BFR (LI-BFR, 6). Each seated chest press, row and shoulder press...
Many studies have reported the frequency and types of injuries in high school football players. However, few assessed relationship between player characteristics risk injury.To describe epidemiologic factors for injury players to determine whether players' could be used predict subsequent injury.Prospective cohort study.This study was part a 2-year prospective investigation (1998 1999) 717 (343 1998 season 374 1999 season) Oklahoma City, Oklahoma, School District. Player (playing experience,...
Abstract Rust fungi (Pucciniales, Basidiomycota) are a species-rich (ca. 8000 species), globally distributed order of obligate plant pathogens. species host-specific, and as group they cause disease on many our most economically and/or ecologically significant plants. As such, the ability to accurately rapidly identify these is particular interest mycologists, botanists, agricultural scientists, farmers, quarantine officials, associated stakeholders. However, complexities rust life cycle,...
The mechanism of N-methyltryptophan oxidase, a flavin-dependent amine oxidase from Escherichia coli, was studied using combination kinetic isotope effects and theoretical calculations. 15(kcat/Km) effect for sarcosine oxidation is pH-dependent with limiting value 0.994−0.995 at high pH. Density functional theory calculations on model systems were used to interpret these effects. are inconsistent proposed mechanisms involving covalent amine-flavin adducts but cannot by themselves conclusively...
Jumping mechanography uses maximal countermovement jumps to test obtain such as jump power (JPow). Recently, it has been shown be a safe method for assessing muscle function in older adults; however, little is known about the relationships between JPow, strength, and sarcopenia status. The purpose of this study was examine performance, status adults.This cross-sectional that included men (n = 27) women 33) (55-75 years) recruited from general community. Participants completed health physical...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMagnetic Field Dependence of Electron Transfer and the Role Spin in Heme Enzymes: Horseradish PeroxidaseMarc B. Taraban, Tatyana V. Leshina, Mark A. Anderson, Charles GrissomView Author Information Institute Chemical Kinetics Combustion Novosibirsk-90, 630090 Russia Department Chemistry, University Utah Salt Lake City, 84112 Cite this: J. Am. Chem. Soc. 1997, 119, 24, 5768–5769Publication Date (Web):June 18, 1997Publication History Received28...
Biomaterial vehicles have the potential to facilitate cell transplantation in central nervous system (CNS). We previously shown that highly tunable ionic diblock copolypeptide hydrogels (DCH) can provide sustained release of hydrophilic and hydrophobic molecules CNS. Here, we show recently developed nonionic thermoresponsive DCH, called DCHT, exhibit excellent cytocompatibility. Neural stem (NSC) suspensions DCHT were easily injected as liquids at room temperature. with a viscosity tuned...