A5043161236- Regulation of Appetite and Obesity
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Marine animal studies overview
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Eating Disorders and Behaviors
- Color perception and design
- Metabolism, Diabetes, and Cancer
- Stress Responses and Cortisol
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Neuroendocrine regulation and behavior
- Congenital Heart Disease Studies
- Behavioral and Psychological Studies
- Memory and Neural Mechanisms
- Avian ecology and behavior
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Mental Health Research Topics
University of Gothenburg
2018-2024
University of Liège
2014-2019
Erasmus University Rotterdam
2011
The rodent whisker system is widely used as a model for investigating sensorimotor integration, neural mechanisms of complex cognitive tasks, development, and robotics. pathways to the barrel cortex have received considerable attention. However, many subcortical structures are paramount system. They contribute important processes, like filtering out salient features, integration with other senses, adaptation general behavioral state animal. We present here an overview brain regions their...
Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce alcohol drinking in rodents and overweight patients with use disorder (AUD). However, the probability of low semaglutide doses, an agonist higher potency affinity for GLP-1R, attenuate alcohol-related responses underlying neuronal mechanisms is unknown.In intermittent access model, we examined ability decrease intake block relapse-like drinking, as well imaging binding fluorescently marked nucleus accumbens (NAc)...
Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, mechanisms by which it controls energy balance its role in obesity remain unclear. Here, we show that is decreased obese mice rats a neuroanatomically sex-specific manner. Reduced mRNA localized to lateral parabrachial nucleus (lPBN) astrocytes, microglia, neurons, including paraventricular hypothalamus-innervating lPBN neurons. microinjection into reduced food intake...
The supramammillary nucleus (SuM) is nestled between the lateral hypothalamus (LH) and ventral tegmental area (VTA). This neuroanatomical position consistent with a potential role of this to regulate ingestive motivated behavior. Here neuroanatomical, molecular, behavior approaches are utilized determine whether SuM contributes food-motivated control. Through application anterograde retrograde neural tract tracing novel designer viral vectors, current findings show that neurons densely...
Food intake behavior is under the tight control of central nervous system. Most studies to date focus on contribution neurons this behavior. However, although previously overlooked, astrocytes have recently been implicated play a key role in feeding control. recent literature has focused astrocytic hypothalamus or dorsal vagal complex. The located lateral parabrachial nucleus (lPBN) remains poorly understood. Thus, here, we first investigated whether activation lPBN affects male and female...
In songbirds, neurogenesis in the song control nucleus HVC is sensitive to hormonal and social environment but dynamics of this process difficult assess with a single exogenous marker new neurons. We simultaneously used three independent markers investigate male female canaries. Males were castrated, implanted testosterone housed either alone (M), (M-F) or another (M-M) while females 17β-estradiol (F-M). All subjects received injections two thymidine analogues, BrdU EdU, respectively 21 10...
Anxiety disorders are among the most prevalent categories of mental illnesses. The gut-brain axis, along with gastrointestinally-derived neuropeptides, like glucagon-like peptide-1 (GLP-1), emerging as potential key regulators emotionality, including anxiety behavior. However, neuroanatomical substrates from which GLP-1 exerts its anxiogenic effect remain poorly characterized. Here we focus on a relatively new candidate nucleus, supramammillary nucleus (SuM), located just caudal to lateral...
Testosterone plays a key role in the control of seasonal changes singing behavior and its underlying neural circuitry. After administration exogenous testosterone, song quality nuclei volumes change over course weeks, but rate increases within days. The medial preoptic nucleus (POM) controls sexual motivation testosterone action POM sexually motivated singing. In this study, we investigated time POM, at gross anatomical cellular level. Photosensitive female canaries were injected with BrdU...
In male songbirds, the motivation to sing is largely regulated by testosterone (T) action in medial preoptic area, whereas T acts on song control nuclei modulate aspects of quality. Stereotaxic implantation nucleus (POM) castrated canaries activates a high rate singing activity, albeit with longer latency than after systemic treatment. Systemic also increases occurrence male-like female canaries. We hypothesized that this effect mediated POM. Females were stereotaxically implanted either or...
Abstract Aggression is a complex social behavior, which provoked in the defense of limited resources including food and mates. Recent advances show that gut-brain hormone ghrelin modulates aggressive behaviors. As glucagon-like peptide-1 (GLP-1) reduces intake sexual behaviors its potential role likely. Therefore, we investigated tentative link between GLP-1 by combining preclinical human genetic-association studies. The influence acute or repeated injections receptor (GLP-1R) agonist,...
The pro-inflammatory role of interleukin-6 (IL-6) is well-characterized. Blockade IL-6, by Tocilizumab, used in patients with rheumatoid arthritis and those diagnosed cytokine storm. However, brain-produced IL-6 has recently emerged as a critical mediator gut/adipose communication the brain. Central nervous system (CNS) engaged peripheral central signals regulating energy homeostasis. for mediating hypophagia weight loss effects GLP-1 analog, exendin-4, clinically utilized drug....
Pancreatic insulin was discovered a century ago, and this discovery led to the first lifesaving treatment for diabetes. While still controversial, nearly one hundred published reports suggest that is also produced in brain, with most focusing on hypothalamic or cortical insulin-producing cells. However, specific function within brain remains poorly understood. Here we identify expression hindbrain's dorsal vagal complex (DVC), determine role of source feeding metabolism, as well its response...
In two experiments, experimentally naïve rats were trained in concurrent variable‐interval schedules which the reinforcer ratios changed daily according to a pseudorandom binary sequence. Experiment 1, relative response rates showed clear sensitivity current‐session ratios, but not previous sessions' ratios. Within sessions, current session's reinforcement increased steadily, and by session end, approached matching Across ratio decreased with continued exposure sequence, contrary...
The glucagon-like peptide 1 receptor (GLP-1R) has recently emerged as a viable candidate target to treat alcohol use disorder (AUD) its agonists have previously shown prevent alcohol-related responses in rodents and reduce drinking overweight patients with AUD. Here, the long-acting GLP-1R agonist semaglutide was investigated on ability relapse both male female rats. Given that alcohol-induced reward driven by dopamine release nucleus accumbens (NAc) influences drinking, hypothesis inhibits...
Abstract Objective: Combining different pharmaceuticals may be beneficial when treating disorders with complex neurobiology, including alcohol use disorder (AUD). The gut-brain peptides amylin and GLP-1 of potential interest as they individually reduce intake in rodents. While the combination receptor (AMYR) glucagon-like peptide-1 (GLP-1R) agonists have been found to decrease feeding body weight obese male rats synergistically, their combined impact on is unknown. Methods: Therefore, effect...
Event Abstract Back to Perineuronal nets and song learning-related neuroplasticity in the songbird brain Gilles Cornez1*, Elisabeth Jonckers2, Olesya Shevchouk1, Samar Ghorbanpoor1, Gregory Ball3, Annemie Van Der Linden2, Charlotte A. Cornil1 Jacques Balthazart1 1 University of Liège, GIGA Neuroscience, Belgium 2 Antwerpen, Bio-Imaging Lab, 3 Maryland, Department Psychology, United States (PNN) are aggregations extracellular matrix components surrounding soma some neurons, mainly GABAergic...