A5089852058- Acute Myeloid Leukemia Research
- Fullerene Chemistry and Applications
- Immune Cell Function and Interaction
- Chemical Thermodynamics and Molecular Structure
- Advanced Chemical Physics Studies
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Boron and Carbon Nanomaterials Research
- Chronic Myeloid Leukemia Treatments
- Carbon Nanotubes in Composites
- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
First Pavlov State Medical University of St. Petersburg
2019-2024
Chimeric antigen receptor T cell (CAR-T) therapy has recently gained recognition as a transformative treatment of cancer, particularly hematological malignancies. However, CAR-T manufacturing remains major bottleneck this...
Autologous anti-CD19 CAR-T cells can be produced by means of closed automated systems, which seems to the most convenient platform for point-of-care production.However, fully comply with good practices and utilize relatively low-grade clean air environments, production processes should carried out in a completely format, without usage pooled human blood products.The purpose present study was test process that meets necessary requirements.
Background . Myelodysplastic syndrome is a group of malignant blood diseases with high risk transformation into acute myeloid leukemia. One treatment approach to target immune checkpoints (ICs) that are overexpressed on tumor cells. To develop these drugs, relevant models needed for highthroughput screening and study biologically active substances, since traditionally used (mouse patient biomaterials) difficult access, financially laborintensive, characterized by poorly reproducible results....