A5070812958- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Muscle and Compartmental Disorders
- Osteoarthritis Treatment and Mechanisms
- Advanced Glycation End Products research
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrolyte and hormonal disorders
- Renal and related cancers
- Polyomavirus and related diseases
- Research on Leishmaniasis Studies
- Genetic and Kidney Cyst Diseases
- Clinical Nutrition and Gastroenterology
- Vascular Procedures and Complications
University of Tokyo Hospital
2016-2025
The University of Tokyo
2013-2023
Shimane University
2006-2022
Tokyo Medical and Dental University
2019
European Society of Radiology
2019
Toho University
2017
Toho University Omori Medical Center
2017
Japanese Society of Medical Oncology
2016
Century (United States)
2016
Asahi Kasei (Japan)
2016
Experimental evidence has clarified distant organ dysfunctions induced by AKI. Crosstalk between the kidney and heart, which been recognized recently as cardiorenal syndrome, appears to have an important role in clinical settings, but mechanisms AKI causes cardiac injury remain poorly understood. Both heart are highly energy-demanding organs that rich mitochondria. Therefore, we investigated of mitochondrial dynamics kidney–heart crosstalk. Renal ischemia reperfusion (IR) was bilateral renal...
Objective: This study is aimed to examine whether urinary L-type fatty acid-binding protein can detect the severity of sepsis with animal models and septic shock patients complicated established acute kidney injury. Design: Experimental a clinical, prospective observational study. Setting: University laboratory tertiary hospital. Subjects Patients: One hundred fourteen human transgenic mice 145 Interventions: Animals were challenged by abdominal (cecal ligation puncture) pulmonary...
Elucidation of acute kidney diseases and disorders (AKD), including injury (AKI), is important to prevent their progression chronic disease. Current animal AKI models are often too severe for use in evaluating human AKI. Therefore, new mild needed. Here a clinically relevant model using multiple low doses cisplatin (CP) was used evaluate AKD. When 10 mg/kg CP administered intraperitoneally once weekly three times L-type fatty acid-binding protein (L-FABP) transgenic mice, moderate renal...
Accumulating evidence of the beyond-glucose lowering effects a gut-released hormone, glucagon-like peptide-1 (GLP-1), has been reported in context remote organ connections cardiovascular system. Specifically, GLP-1 appears to prevent apoptosis, and inhibition dipeptidyl peptidase-4 (DPP-4), which cleaves GLP-1, is renoprotective rodent ischemia-reperfusion injury models. Whether this renoprotection involves enhanced signaling unclear, however, because DPP-4 other molecules as well. Thus, we...
Abstract Acute kidney disease (AKD), or renal dysfunction persisting >7 days after an initiating event of acute injury, is a rising concern. This study aimed to elucidate the clinical course AKD cardiac surgery with data on post-cardiac patients admitted intensive care units (ICU) at 18 Japanese hospitals during 2012–2014. Using multivariable logistic models, we evaluated association 90-day mortality and 50% eGFR decline 2-year follow-up compared 90 days. was defined as elevation in serum...
Abstract Ligand‐gated chloride channels (LGICs) are important targets for insecticides and parasiticides. Genes encoding subunits of two LGICs, a glutamate‐gated channel (MdGluCl‐α) γ‐aminobutyric acid (GABA)‐gated (MdRdl), were cloned from house‐flies ( Musca domestica L.). These genes first expressed independently in Xenopus laevis oocytes by cRNA injection order to investigate the pharmacology these ligand‐gated using two‐electrode voltage‐clamp electrophysiology. It was found that l...
Abstract Introduction Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an emerging acute kidney injury (AKI) biomarker. We evaluated the performance urinary TIMP-2 in adult mixed ICU by comparison with other biomarkers that reflect several different pathways AKI. Methods In this study, we prospectively enrolled 98 critically ill patients who had been admitted to ICU. Urinary and N -acetyl-β- d -glucosaminidase (NAG) plasma neutrophil gelatinase-associated lipocalin (NGAL), interleukin-6...
Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a stress test (FST) for predicting severe acute kidney injury (AKI) progression. Although standardized dose required FST, variable dosing typically employed based on illness severity, including renal dysfunction in the clinical setting. This study aimed to evaluate whether FR with different doses can predict AKI We further combination of an biomarker, plasma...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background In multiple-organ dysfunction, an injury affecting one organ remotely impacts others, and the injured organs synergistically worsen outcomes. Recently, several mediators, including extracellular histones neutrophil traps, were identified as contributors to distant damage. study aimed elucidate whether these mediators play a crucial role in remote damage induced by intestinal...
Abstract Acute kidney injury (AKI) complicated by acute lung has a detrimental effect on mortality among critically ill patients. Recently, renal ischemia-reperfusion (IR) model suggested the involvement of histones and neutrophil extracellular traps (NETs) in development distant after IR. Given that recombinant thrombomodulin (rTM) anti-inflammatory roles binding to circulating histones, we aimed clarify its induced AKI murine bilateral IR model. Both pretreatment delayed treatment with rTM...
We aimed to examine recent trends in patient characteristics and mortality patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) intermittent (IRRT), intensive care units (ICUs).From the Diagnosis Procedure Combination database Japan during 6 months (July-December) from 2007 2016, we identified AKI who received ICUs. restricted study participants those admitted hospitals (in which both CRRT IRRT were available) that participated...
To examine the effect of thiamine administration on mortality in patients with septic shock requiring norepinephrine.
For patients with end-stage renal disease (ESRD), due to the heterogeneity of population, appropriate risk assessment approaches and strategies for further follow-up remain scarce. We aimed conduct a pilot study better stratification, applying machine learning-based classification ESRD who newly started maintenance hemodialysis.We prospectively studied 101 ESRD, were new hemodialysis therapy, between August 2016 March 2018. Baseline values variables such as blood urine tests obtained before...
For peritonitis, a serious complication of peritoneal dialysis (PD), we investigated the relation between duration from sign (PD effluent abnormalities) to treatment with appropriate antibiotics (ST time) and catheter removal. 62 PD hospital patients, data PD-related peritonitis (n = 109) were collected retrospectively. We examined ST time removal times using univariate multivariate analyses. The rate in delayed group (≥ 24 h) was higher than that early (< (38 vs. 16%, p 0.02). Concomitant...
Post-transplant lymphoproliferative disorder (PTLD) affects from 0.8-2.5% of kidney transplant patients, with peaks in incidence within 1 year and 10-14 years post-transplant. Very late-onset PTLD (VL-PTLD) can occur over 10 post-transplant, reportedly up to 30 years, but its characteristics remain unclear. A 61-year-old man developed 45 after transplant, presenting fever shortness breath. Computed tomography revealed lung liver masses biopsy-confirmed stage IVB monomorphic PTLD. Despite...
No standardized criteria for continuous renal replacement therapy (CRRT) discontinuation have been established. Kinetic estimated glomerular filtration rate (eGFR) is a newly developed estimation method based on dynamic changes of serum creatinine expected to reflect the true GFR. This study aimed evaluate predictive role kinetic eGFR CRRT discontinuation.A retrospective single-centre cohort was conducted. Acute kidney injury (AKI) patients who received between May 2015 and April 2016 were...
Background: The health-related quality of life (HRQOL) dialysis patients has not been well examined, especially in combination therapy with peritoneal and hemodialysis (PD+HD) patients. We compared the HRQOL PD+HD that HD PD Methods: A multicenter, cross-sectional study was conducted on 36 PD+HD, 103 HD, 90 Japan who completed Kidney Disease Quality Life Short Form 36, version 1.3. scores were summarized into physical- (PCS), mental- (MCS), role/social- (RCS), kidney disease component...