A5065413179- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Palliative Care and End-of-Life Issues
- Chronic Disease Management Strategies
- Multiple Sclerosis Research Studies
- Patient-Provider Communication in Healthcare
- Geriatric Care and Nursing Homes
- Neonatal and fetal brain pathology
- Clinical practice guidelines implementation
- Diet and metabolism studies
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Childhood Cancer Survivors' Quality of Life
- Genetic Neurodegenerative Diseases
- Healthcare cost, quality, practices
- Cardiovascular Health and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Healthcare Systems and Technology
Icahn School of Medicine at Mount Sinai
2016-2025
American Academy of Neurology
1997-2024
Hudson Institute
2024
John Wiley & Sons (United States)
2022-2024
The University of Texas Southwestern Medical Center
2024
University of South Florida
2024
Neurology, Inc
2013-2022
Mount Sinai Health System
2021
Sinai Health System
2020
University of California, Los Angeles
2009-2019
Summary: We developed an instrument to measure health‐related quality of life (HRQOL) in epilepsy. A 99‐item inventory was constructed from the RAND 36‐Item Health Survey (generic core), with 9 additional generic items, 48 epilepsy‐targeted and 6 other items concerning attitudes toward epilepsy self‐esteem. administered 304 adults at 25 centers. Patients patient‐designated proxies completed were retested 1–91 days later. multitrait scaling analysis these data led retention 86 distributed 17...
Background: Adherence to dementia guidelines is poor despite evidence that some guideline recommendations can improve symptoms and delay institutionalization of patients. Objective: To test the effectiveness a guideline–based disease management program on quality care outcomes for patients with dementia. Design: Clinic-level, cluster randomized, controlled trial. Setting: 3 health organizations collaborating community agencies in southern California. Participants: 18 primary clinics 408 age...
Summary: Purpose: Previous research suggests that seizure freedom may be necessary to improve health‐related quality of life (HRQOL) for epilepsy surgery patients, but little is known regarding the seizure‐frequency reduction needed HRQOL among medically treated individuals. Methods: With data from 134 adults with refractory complex partial seizures participating in a randomized controlled antiepileptic drug (AED) trial, we compared change across groups having different levels frequency:...
OBJECTIVE: We compared associations of epilepsy remission status and severity as well psychiatric other comorbidities with child parent-proxy reports health-related quality life (HRQoL) in adolescents previously diagnosed epilepsy. METHODS: In a prospective, community-based study newly childhood epilepsy, HRQoL 277 children was assessed 8 to 9 years after diagnosis by using versions the Child Health Questionnaire (CHQ). Multiple linear regression models adjusted for age gender were used...
Asian Americans (AsA), Native Hawaiians, and Pacific Islanders (NHPI) comprise 7.7% of the U.S. population, AsA have had fastest growth rate since 2010. Yet National Institutes Health (NIH) has invested only 0.17% its budget on NHPI research between 1992 2018. More than 40 ethnic subgroups are included within (with no majority subpopulation), which highly diverse culturally, demographically, linguistically, socioeconomically. However, data for these groups often aggregated, masking critical...
A retrospective study was carried out to determine whether a prior cerebral injury or medical illness associated with hippocampal sclerosis in intractable, surgically treated temporal lobe epilepsy (TLE), there evidence for progressive neuron damage from repeated seizures. Temporal patients (n = 162) one centre were retrospectively and blindly catalogued into groups based on the presence absence of an initial precipitating (IPI) whether, when IPI present, it had involved seizures...
The goals of surgery in treating intractable epilepsy are to eliminate seizures and improve quality life. This report describes the development Epilepsy Surgery Inventory (ESI)-55, a 55-item measure health-related life for patients. ESI-55 includes following scales (number items parentheses): health perceptions (9), energy/fatigue (4), overall (2), social function emotional well-being (5), cognitive physical (10), pain three separate role limitations due emotional, physical, or memory...
<b>Background: </b> In a seven-center prospective observational study of resective epilepsy surgery, the authors examined probability and predictors entering 2-year remission risk subsequent relapse. <b>Methods: Patients aged 12 years over were enrolled at time referral for underwent standardized evaluation, treatment, follow-up procedures. The defined seizure as 2 completely seizure-free after hospital discharge with or without auras, relapse any seizures remission. type seizure, clinical...
To examine the relationship of objectively assessed cognitive functioning to self-reported quality life.Correlational, multiple regression, and factor analytic comparisons a new self-report life inventory with neuropsychological tests cognition mood.Two hundred fifty-seven patients epilepsy.Twenty-five epilepsy centers neurology clinics across United States.A recently developed (ie, Quality Life in Epilepsy-89 inventory) objective memory, verbal abilities, spatial functions, psychomotor...
<b><i>Objective:</i></b> To compare the health-related quality of life (HRQL) a nonsurgical sample adults with epilepsy that age- and gender-equivalent norms, to analyze relative importance seizure frequency, time since last seizure, gender, comorbidity on HRQL in sample. <b><i>Methods:</i></b> Data were obtained from 139 three US centers published norms Medical Outcomes Study Short-Form 36 (SF-36). Patients classified according number seizures over prior 4 weeks (zero, one five, six or...
<b><i>Background:</i></b> Much remains unknown about the natural history of intractable localization-related epilepsy, including how long it typically takes before intractability becomes evident. This information could guide design future studies, resolve certain discrepancies in literature, and provide more accurate long-term prognosis. <b><i>Methods:</i></b> Individuals evaluated for resective surgery refractory epilepsy were prospectively identified at time initial surgical evaluation...
<b>Objective: </b> To determine changes in depression and anxiety after resective surgery. <b>Methods: Data from subjects enrolled a prospective multicenter study of epilepsy surgery were reviewed with the Beck Psychiatric Symptoms Scales (Beck Depression Inventory [BDI] Anxiety [BAI]) Composite International Diagnostic Interview (CIDI) up to 24-month period. χ<sup>2</sup> analyses used correlate proportions. <b>Results: A total 358 presurgical BDI 360 BAI results reviewed. Moderate severe...
To determine prospectively when in the course of epilepsy intractability becomes apparent.Data are from a prospective cohort 613 children followed for median 9.7 years. Epilepsy syndromes were grouped: focal, idiopathic, catastrophic, and other. Intractability was defined two ways: (1) 2 drugs failed, 1 seizure/month, on average, 18 months (stringent), (2) failure drugs. Delayed as 3 or more years after diagnosis.Eighty-three (13.8%) met stringent 142 (23.2%) two-drug definition. depended...
<b><i>Objective:</i></b> To obtain prospective data regarding seizures, anxiety, depression, and quality of life (QOL) outcomes after resective epilepsy surgery. <b><i>Methods:</i></b> The authors characterized surgery patients prospectively at yearly intervals for seizure outcome, QOL, using standardized instruments patient interviews. <b><i>Results:</i></b> Of 396 who underwent surgical procedures, 355 were followed least 1 year. these, 75% achieved a 1-year remission some time during...
The purpose of this investigation was to compare self-reported health-related quality life (HRQOL) in epilepsy compared another neurological condition or a non-neurological chronic illness. Patients with (N = 271), multiple sclerosis 85) and diabetes 555) completed generic measure HRQOL (RAND 36-Item Health Survey 1.0 (SF-36)), the eight SF-36 scale scores were across groups, adjusting for differences sociodemographic characteristics co-morbid medical conditions. reported significantly worse...
Summary: Purpose: Multiple studies have examined predictors of seizure outcomes after epilepsy surgery. Most are single‐center series with limited sample size. Little information is available about the selection process for surgery and, in particular, proportion patients who ultimately and characteristics that identify those do versus not. Such necessary providing epidemiologic clinical context which currently performed United States other developed countries. Methods: An observational...
In North America, overall epilepsy incidence is approximately 50/100,000 per year, highest for children below five years of age, and the elderly. The best data suggest prevalence 5-10/1000. Potential effects gender, ethnicity, access to care socioeconomic variables need further study. Studies etiology classification mainly were performed without modern imaging tools. study found an standardized mortality ratio (SMR) relative general population 2.3. There evidence a greater increase in...
Abstract Epilepsy surgery is an increasingly common treatment for intractable epilepsy; yet there no clear consensus among experts on how to report epilepsy outcome. Most published outcome reporting systems focus seizure frequency and type but differ in they define clinically distinct categories. We used a reliable valid measure of self‐reported health‐related quality life (HRQOL), the Surgery Inventory (ESI)‐55, as external standard by which evaluate seven previously published,...
<h3>Objective:</h3> To determine the most critical symptoms in a national myotonic dystrophy type 1 (DM1) population and to identify modifying factors that have greatest effect on severity of these symptoms. <h3>Methods:</h3> We performed cross-sectional study 278 adult patients with DM1 from registry between April August 2010. assessed prevalence relative significance 221 14 disease themes. These themes were chosen for evaluation based prior interviews DM1. Responses categorized by age, CTG...
Abstract Objective Health‐related quality of life (HRQOL) improves after resective epilepsy surgery, but data are limited to short follow‐up in mostly retrospective reports, with minimal consideration other potential factors that might influence HRQOL. Methods In a prospective multicenter study, 396 patients underwent surgery. They completed the Quality Life Epilepsy Inventory‐89 (QOLIE‐89) before within 6 months, and at approximately yearly intervals Seizure outcome was ascertained by phone...