A5055419258- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Neurological Complications and Syndromes
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Renal and Vascular Pathologies
- Cardiovascular Issues in Pregnancy
- Prenatal Screening and Diagnostics
- Gestational Trophoblastic Disease Studies
- Ectopic Pregnancy Diagnosis and Management
Radboud University Medical Center
2012-2025
Radboud University Nijmegen
2012-2025
Erasmus MC
2022
Hôpital René Huguenin
2015
Institut Curie
2015
Centrum voor Gynaecologische Oncologie Amsterdam
2011
Introduction Despite being a leading cause of female morbidity and mortality, female-specific cardiovascular disease (CVD) is understudied, underdiagnosed undertreated. Pregnancy complications involving the placenta, including pre-eclampsia, pregnancy-induced hypertension foetal growth restriction, are thought to reflect global maternal vascular derangements that indicate twofold eightfold increased risk future CVD. This calls for better understanding pathophysiology allow development...
A subgroup of preeclamptic women has spiral artery lesions termed decidual vasculopathy (DV) which relate to worse clinical outcome. We aimed determine whether a history preeclampsia (PE) with DV is associated adverse overall and future pregnancy outcome, including increased recurrence risk hypertensive diseases pregnancy.Via posted survey PE (DV positive) in the index were compared those without negative) on outcome.DV positive cases showed higher incidence chronic hypertension both...
Abstract Introduction Placental syndrome is an umbrella term encompassing the clinical phenotypes of preeclampsia and fetal growth restriction, associated with high maternal neonatal morbidity. In women placental syndrome, histologicl examination uteroplacental unit commonly demonstrates pathological lesions, such as decidual vasculopathy. Decidual vasculopathy are changes in spiral arteries, which adverse outcome long‐term cardiovascular health. The relation between pathology has been...
The sequence of the beta-subunit human chorionic gonadotropin (hCGβ) varies depending on whether hCGβ is encoded by type I or II genes. Type genes are upregulated in trophoblast and cancer but can be detected serum nonpregnant women healthy individuals. We aimed to determine monoclonal antibody (mAb) FBT11-II specifically detects (type hCGβ).Competitive inhibition assays with synthetic peptides, immunocytochemical immunohistochemical studies, dosing immunoassays sequencing CGB were...