A5022194280- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Disease Prevention
- Reproductive System and Pregnancy
- Heart Rate Variability and Autonomic Control
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Thermoregulation and physiological responses
- Maternal and fetal healthcare
- Blood Pressure and Hypertension Studies
- Pelvic floor disorders treatments
- Muscle Physiology and Disorders
- Ectopic Pregnancy Diagnosis and Management
- Infant Development and Preterm Care
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Sports Performance and Training
- Neonatal Respiratory Health Research
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Disease and Adiposity
- Myasthenia Gravis and Thymoma
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Radboud University Nijmegen
2015-2025
Radboud University Medical Center
2015-2025
Maastricht University
2019-2023
Catharina Ziekenhuis
2023
University Medical Center
2019
University of Toronto
2017-2018
Mount Sinai Hospital
2018
Lunenfeld-Tanenbaum Research Institute
2018
Sinai Health System
2017-2018
Maastricht University Medical Centre
2011-2016
The purpose of this study was to establish normal values muscle thickness, ratio thickness subcutaneous fat and echo intensity in children between 11 weeks 16 years age. Transverse scans four muscles were made by standardized real-time ultrasound examination. digitized, mean measured using gray-scale analysis. A multiple regression equation used which independent parameter (age, height, weight, or sex) influenced the variables for each muscle. Muscle depended on child's weight. other...
A model based on the soluble Fms-like tyrosine kinase-1/placental growth factor ratio, gestational age, and urinary protein-to-creatinine ratio (PRERISK calculator) has been developed to predict preeclampsia-related maternal-fetal complications. Here, we tested whether this can reduce hospital admissions without increasing complication rates among women with suspected or confirmed preeclampsia. In multicenter, open-label, randomized controlled trial conducted at 5 Dutch medical centers,...
ABSTRACT Objectives Pre‐eclampsia (PE) is associated with both postpartum structural asymptomatic heart disease (i.e. failure Stage B (HF‐B)) and conventional cardiovascular (CV) risk factors. We aimed to evaluate the extent which PE, adjusted for CV factors, independently cardiac abnormalities postpartum. Methods In this cross‐sectional cohort study, 107 formerly pre‐eclamptic women 41 uneventful previous pregnancy (controls) were invited assessment 4–10 years This included ultrasound,...
Is menstrual blood a suitable source of endometrial derived lymphocytes?Mononuclear cells isolated from samples (menstrual mononuclear (MMC)) are clearly distinct peripheral (PBMC) and show strong resemblance with biopsy-derived cells.A critical event in the onset pregnancy is implantation embryo uterine wall. The immune cell composition endometrium at time considered pivotal for success. Despite advancing knowledge on population uterus, role reproductive disorders still not fully resolved,...
The objectives of our study were to examine 1) the proportion responders and nonresponders exercise training in terms vascular function; 2) a priori factors related training-induced changes conduit artery function, 3) contribution traditional cardiovascular risk exercise-induced function. We pooled data from laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type interventions with pre-/posttraining measures flow-mediated dilation (FMD%) assess All...
Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS should not only address technical issues, but also consider socio-ethical legal aspects, its application area, corresponding design implications. This paper represents consensus opinion group healthcare professionals, designers, ethicists, researchers patient representatives, who have expertise tertiary obstetric neonatal care,...
We determined prospectively the diagnostic value of quantitative ultrasonography in detecting neuromuscular disorders children. Ultrasonographic scans four muscles were made 36 children with symptoms or signs suggestive disease, such as muscle weakness and hypotonia. The thickness, ratio thickness to subcutaneous fat echo intensity each muscle. was measured using computer-assisted gray-scale analysis. Thirteen patients had a disorder (6 myopathy 7 neuropathy). Differentiation between...
Objective To analyse the predicted 10‐ and 30‐year risk scores for cardiovascular disease ( CVD ) in patients who experienced preeclampsia PE 5–10 years previously compared with healthy parous controls. Design Observational study. Setting Tertiary referral hospital Netherlands. Population One hundred fifteen a history of 50 were categorised into two groups, hypertensive n = 21) normotensive 94), based on use antihypertensive medication, next subgroups onset : early‐onset 39) late‐onset 76)....
Formerly preeclamptic women are at increased risk for remote cardiovascular and thrombotic diseases. We studied co-occurrence of prothrombotic factors within a cohort formerly tested if prevalence these profiles related to onset preeclampsia in previous pregnancy.We evaluated 1,297 nonpregnant (6-12 months postpartum) the presence four profiles: circulatory profile (hypertension or latent hypertension [low plasma volume, vascular resistance, both]; metabolic syndrome (World Health...
Importance Maternal tetanus, diphtheria, and acellular pertussis (Tdap) vaccination protects newborns against severe pertussis. Data on transplacental antibody transfer Tdap before 24 weeks’ gestation remain scarce are particularly relevant for preterm infants to increase the time interval maternal transfer. Objective To assess noninferiority of anti–pertussis toxin (anti-PT) immunoglobulin G (IgG) levels at age 2 months in early- late-term following between 20 0/7 compared with 30 33...
Objective To study the prevalence of metabolic syndrome in women after a pregnancy complicated by pre‐eclampsia or small‐for‐gestational‐age ( SGA ), both epitomes placental syndrome. Design A retrospective cohort study. Setting Single tertiary centre for maternal medicine Netherlands. Population Women with history absence n = 742) normotensive 147) between 1996 and 2010. Methods were routinely screened underlying cardiometabolic cardiovascular risk factors at least 6 months postpartum....
ABSTRACT Objectives After pre‐eclampsia (PE), the prevalence of structural heart disease without symptoms, i.e. failure Stage B (HF‐B), may be as high one in four women first year postpartum. We hypothesize that a significant number formerly pre‐eclamptic with HF‐B postpartum are still their resolving period and will not have during follow‐up. Methods In this prospective longitudinal cohort study, we included 69 who underwent serial echocardiographic measurements at 1 4 years was diagnosed...
Pre-eclampsia (PE) is associated with both postpartum endothelial dysfunction and asymptomatic structural heart alterations consistent failure Stage B (HF-B). In this study, we assessed the relationship between function, measured by flow-mediated dilation (FMD), HF-B in women a history of PE.This was an observational study which 67 formerly pre-eclamptic (≥ 4 years postpartum) 37 healthy parous controls were ultrasonographically for cardiac function geometry, as well means brachial artery...
In Brief OBJECTIVE: To estimate whether recurrence risks of preeclampsia, preterm birth, and fetal growth restriction relate to prepregnancy plasma volume. METHODS: We conducted a retrospective cohort study in 580 formerly preeclamptic women control group. all we measured volume (iodine125-human serum albumin indicator dilution method) the nonpregnant state. One hundred seventy-eight normotensive (formerly preeclamptic) had subsequent pregnancy within period (1996–2008). Odds ratios (ORs)...
Maintaining a proper fluid balance is important during exercise as athletes are prone to develop dehydration exercise. Although several factors may regulate the balance, little known about role of sex prolonged moderate-intensity Therefore, we compared body mass changes and parameters in men vs women large heterogeneous group participants Ninety-eight volunteers walked 30-50 km at self-selected pace. Exercise duration (8 h, 32 min) intensity (69% HRmax) were comparable between groups. Men...
Atherosclerosis is a lifelong process involving artery wall thickening. Increased thickness has been widely adopted as preclinical surrogate marker of atherosclerosis. A prerequisite for such that it structural characteristic the vessel not subject to acute changes. The purpose this study was examine effects vasodilator drug administration on carotid and superficial femoral arteries. High-resolution ultrasound used diameters in 15 young (25±4 years age) older (70±6 healthy men who were...
Abstract Background Although previous studies have reported age‐related wall thickening in carotid arteries, it is not clear whether this a systemic phenomenon which also apparent peripheral conduit arteries or thickness ( WT ) changes occur to similar degree men and women. Aim To determine sex modifies the impact of ageing on wall‐to‐lumen ratio (W:L) atherosclerosis‐prone (i.e. artery, femoral, superficial popliteal artery) atherosclerosis‐resistant brachial arteries. Methods We included...
Objective To compare the prevalence of recurrent pre‐eclampsia between women who have and do not metabolic syndrome when non‐pregnant. Design Retrospective cohort study. Setting Three tertiary referral hospitals in Netherlands. Population Formerly pre‐eclamptic women. Methods The presence or absence was assessed 480 at least 6 months after their first pregnancy using World Health Organization criteria. We compared subsequent pregnancy, calculating odds ratios ( OR ), adjusted for...