A5033585619- Preterm Birth and Chorioamnionitis
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Pregnancy-related medical research
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Disability Support Research
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Case Reports on Hematomas
- Synthesis and Properties of Aromatic Compounds
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Neurological and metabolic disorders
- Fullerene Chemistry and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Pelvic floor disorders treatments
- Poisoning and overdose treatments
- Boron and Carbon Nanomaterials Research
- Health Policy Implementation Science
- Child Abuse and Related Trauma
- Pneumonia and Respiratory Infections
- Neonatal and fetal brain pathology
- Trauma and Emergency Care Studies
University of Amsterdam
1982-2025
Amsterdam University Medical Centers
2019-2025
Vrije Universiteit Amsterdam
1973-2022
University Medical Center Utrecht
2013-2017
Radboud University Nijmegen
2009-2016
Radboud University Medical Center
2009-2016
University Medical Center Groningen
2013
Amsterdam UMC Location University of Amsterdam
2013
Leiden University Medical Center
2013
Maastricht University
2013
RETERM BIRTH IS THE MOST COMmon cause of neonatal morbidity and mortality worldwide.Almost 75% perinatal deaths occur in infants born before 37 weeks' gestation. 1Consequently, pre-term birth is associated with a large burden disease, high costs for medical care, special education, institutionalized care disabled infants. 2 In threatened preterm labor 34 weeks, delay delivery 48 hours allows antenatal corticosteroid treatment to improve fetal maturity transfer the pregnant woman center...
Abstract Objective To evaluate whether serial transvaginal sonographic examination of the cervix with woman in a standing position improves prediction spontaneous preterm birth (SPB) compared conventional posture. Methods For both recumbent and upright maternal position, inter‐ intraobserver agreement cervical length (CL) measurement was calculated. In 363 pregnancies at risk for SPB, we determined prospectively CL funnel width (FW) including differences between positions longitudinal...
Objective In an unselected group of women with signs preterm labour, maintenance tocolysis is not effective in the prevention birth and does improve neonatal outcome. Among those who are fetal fibronectin positive have increased risk birth. We investigated whether nifedipine would delay delivery outcome threatened labour a status. Study Design Women singleton pregnancy (24 +0 to 33 +6 weeks) test were randomised or placebo. medication was continued until 36 completed weeks' gestation. The...
To compare the long-term effects of tocolysis with nifedipine or atosiban on child outcome at age 2.5-5.5 years.The APOSTEL III trial was a multicentre randomised controlled that compared in 503 women threatened preterm birth. Neonatal outcomes did not differ between both treatment arms, except for higher incidence intubation group.Parents were asked to complete four questionnaires regarding neurodevelopment, executive function, behaviour problems and general health.The main measure...
To examine the predictive value of cervical length as measured by transvaginal sonography (TVS) in supine and upright maternal positions for mode delivery induction-to-delivery interval after induction labor at term, to compare these measurements with Bishop score its value.TVS measurement digital examination cervix were performed 68 nulliparous 34 parous women before term. In assessing TVS parameters a vaginal only included analysis, since all delivered vaginally. Both analysis interval....
Preterm birth is the most common cause of neonatal morbidity and mortality worldwide associated with long-term burdens. The effectiveness maintenance tocolysis on pregnancy perinatal outcomes has not been demonstrated. This multicenter, double-blind, placebo-controlled trial was designed to evaluate nifedipine outcome. Eligible women had threatened preterm labor at 26 32 weeks’ gestation delivered after a 48-hour course tocolytics corticosteroids. Study medication 20 mg slow-release tablets...
Objective The aim of this study was to assess which characteristics and results vaginal examination are predictive for delivery within 7 days, in women with threatened preterm labor after initial treatment. Study Design A secondary analysis a randomized controlled trial on maintenance nifedipine includes who remained undelivered 48 hours. We developed one model premature prelabor rupture membranes (PPROM) without PPROM. predictors were identified by backward selection. assessed calibration...
Spontaneous preterm birth is the leading cause of infant morbidity and mortality in developed world. Environmental socio-economic factors, such as neighborhood deprivation, are known to negatively affect outcomes, including overall birth. However, role deprivation spontaneous (SPTB) unclear. The aim study 1) determine effect on SPTB 2) investigate trend rates between 2010 2019 for each quintile deprivation.Based national perinatal registry, we included 1,584,225 singleton pregnancies...
Preterm birth complicates >15 million pregnancies annually worldwide. In many countries, women who present with signs of preterm labour are treated tocolytics for 48 hours. Although this delays birth, it has never been shown to improve neonatal outcome. 2015, the WHO stated that use should be reconsidered and large placebo-controlled studies evaluate effectiveness urgently needed.We designed an international, multicentre, randomised, double-blinded, clinical trial. Women threatened...
Abstract Introduction Preterm birth (PTB) is the leading cause of infant mortality and morbidity worldwide. Rates PTB in Netherlands are declining, possibly due to implementation preventive strategies. In this study we assessed overall trend rates recent years, more detail specific subgroups investigate potential groups that require scrutiny near future. Material methods Based on national perinatal registry, included all pregnancies without severe congenital abnormalities resulting a from 24...
When generating guidelines, quality of evidence is frequently reported in tabulated form capturing several domains, for example, study design, risk bias and heterogeneity.Increasingly, this done using the Grading Recommendations Assessment, Development Evaluation approach.As assimilating large amount data across comparisons outcomes spread over many pages (sometimes hundreds) not easy, there a need to present summaries more effective way.A graphic display plotting domains used grading on...
Objective To evaluate long‐term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome the infant. Design, Setting and Population Follow up infants women who participated in a multicentre randomised controlled trial versus placebo. Methods Two years after APOSTEL II placebo, we asked participants to complete Ages Stages Questionnaire. Main measures Infant development was measured five domains. Developmental delay defined as score ≤1 SD one or more developmental We...
Women of Black and other non-Western ethnicity women who live in deprived neighborhoods are at increased risk for preterm birth (PTB). These may clustered certain urban areas. If reflects a biological rather than socioeconomic factor, should have PTB independent the area where they live. In this study we explored association between living PTB, combined with knowledge on neighborhood deprivation these specific areas Netherlands.National cohort 935,381 (2014-2019) singleton pregnancy...
Preterm birth presents a significant challenge in clinical obstetrics, requiring effective strategies to reduce associated mortality and morbidity risks. Tocolytic drugs, aimed at inhibiting uterine contractions, are key aspect of addressing this challenge. Despite extensive research over many years, determining the most tocolytic agents remains complex task, prompting better understanding underlying mechanisms spontaneous preterm recording meaningful outcome measures. This paper provides...
Preterm labour is the main cause of perinatal morbidity and mortality in Western world. At present, there evidence that tocolysis for 48 hours useful women with threatened preterm at least before 32 weeks. This allows transfer patient to a centre, maximizes effect corticosteroids improved neonatal survival. It questionable whether treatment tocolytics should be maintained after hours. The APOSTEL II trial multicentre placebo-controlled study. Pregnant admitted who have been treated will...
The pharmacokinetics of nifedipine as a tocolytic agent has not been studied in great detail pregnant women and instead focused on immediate release tablets gastrointestinal therapeutic system (GITS) tablets. aim this study was to determine slow-release half-life distribution volume compare these with pharmacokinetic parameters non-pregnant subjects described the literature.This is parallel trial studying threatened preterm labor between 26 + 0 32 2 weeks after initial tocolysis completed...
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal and information, but is committed maintaining privacy will not share personal information without express consent. For more please refer our Privacy Policy. eTOC Secondary Logo Journal All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Login & Issues Current IssuePrevious Collections Obstetric Airway...