A5022203301- Influenza Virus Research Studies
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- interferon and immune responses
- Dermatology and Skin Diseases
- Stress Responses and Cortisol
- Calcium signaling and nucleotide metabolism
- Medical Device Sterilization and Disinfection
- Immune responses and vaccinations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Herpesvirus Infections and Treatments
- Probiotics and Fermented Foods
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Infant Health and Development
- Hepatitis C virus research
- Urticaria and Related Conditions
- Child and Adolescent Health
- Eicosanoids and Hypertension Pharmacology
- Hepatitis Viruses Studies and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Respiratory and Cough-Related Research
Gamalei Institute of Epidemiology and Microbiology
2022-2024
Ministry of Health of the Russian Federation
2021
Relevance. The problem of prevention and treatment influenza remains relevant due to the consistently high incidence rate disease in population all age groups, especially children elderly. Antiviral drugs have become most important tools fight against viruses. main is search development new antiviral that do not side effects. aim present study investigate effect a synthetic drug candidate based on adamantane (NMG 1110) its combination with ribavirin reproduction A virus MDCK cell culture....
Objective. To evaluate the efficacy of therapy for acute respiratory viral infections (ARVIs) in children with antiviral medications: inosine pranobex (Groprinosin®, Gedeon Richter) and Kagocel (Kagocel®, Niarmedic Pharma LLC) comparison symptomatic treatment without etiotropic agents based on clinical laboratory parameters. Patients methods. The observation was conducted an outpatient setting pre-COVID-19 period between 2018 2020. Acute were diagnosed using licensed testing systems by...
The results of previous studies suggest the involvement herpes viruses in development atopic dermatitis and psoriasis, but there is no convincing evidence. Aim study was to evaluate role active herpesvirus infection exacerbation psoriasis. Material methods. analysis incidence infectious mononucleosis, genital herpes, cytomegalovirus infection, skin subcutaneous tissue diseases, dermatitis, psoriasis Russia 2000–2020 carried out. 92 blood donors 97 patients with diseases (44 53 psoriasis)...
Influenza and coronavirus infections are especially dangerous due to being capable of causing pandemics clinical complications in the nervous cardiovascular systems, as well exacerbation chronic diseases (diabetes mellitus, heart failure, obstructive bronchopneumonia, etc.), which can cause delayed death, children under two years age, elderly, individuals with poor health. The aim study was search for compounds effective against these topical viruses possess constant epidemic activity —...
The widespread spread of infection caused by the Epstein-Barr virus (EBV), lack registered vaccines, possibility implementing a transmission mechanism in medical organizations, determine disinfection as main method preventing this disease. aim is to evaluate effectiveness chemical agents approved for use Russian Federation relation EBV-infected cell culture with quantitative DNA determination polymerase chain reaction. Working solutions complex disinfectants used treatment devices were...
Introduction. Respiratory viruses (RV) circulate throughout the world and in all seasons of year. Long-term monitoring distribution respiratory pathogens is necessary to analyze relevance diagnostic systems current viral isolates, assess risks infection need for vaccine development use, as well investigate interdependence RV reproduction mixed infections.
 Objective — study causative agents acute infections (ARVI) Moscow during 2011–2022 by reverse transcription with subsequent...
Введение. Лечение острых респираторных вирусных инфекций, особенно в период эпидемических подъемов, – первоочередная задача для педиатров и врачей других специальностей. После пандемии новой коронавирусной инфекции COVID-19 назрела необходимость оценки эффективности безопасности индуктора интерферона ввиду произошедших изменений циркуляции вирусов. Цель работы. Оценить эффективность комплексной терапии инфекций у детей 3-18 лет сравнении со стандартной терапией условиях рутинной...
The immune system in the embryonic, neonatal and postnatal periods significantly differs from adults. Cytokine gene expression begins during 10th week of embryogenesis. Production interferons (IFN) interleukins (IL) does not exceed 40-50% adult level. Phagocytosis occurs 12th pregnancy. Regulatory T lymphocytes (Treg) amount up to 15% CD4+ lymphocyte population embryonic period, after birth their level decreases 5%, which is typical for In utero immunological tolerance towards own...
Целью настоящего исследования явилась оценка противовирусной активности препарата циклоферон (меглумина акридонацетат) в отношении вируса гриппа A(H3N2)/Aichi/1/68 на модели клеточных культур MDCK и ФЛЭЧ профилактической схеме. Рассмотрены 2 концентрации (50 100 мкг/мл), временные точки экспозиции циклоферона культурах составили 2, 4 24 ч до заражения, множественность заражения вирусом A(H3N2) составила 0,01 MOI клетку. следующие показатели: титры гемагглютинина, уровень экспрессии РНК...
The article presents the results of a study circulation influenza and acute respiratory viral infections in epidemic season 2022-2023 Almaty region population. For this purpose, 600 nasopharyngeal swabs obtained from sick people with infections, bronchitis pneumonia diagnoses were studied by using real-time polymerase chain reaction. reaction indicate among population A viruses (23.00% total number specimens) B (0.83%) predominance subtype A(H1N1)pdm09 (5.50%). In addition, genetic material...
Influenza viruses are widespread worldwide pathogens with a wide range of hosts, including virtually all warm-blooded animals. A have the ability to adapt quickly new hosts due rapid mutation and combinative variability based on high rates segmented genome structure. The ever-growing strains that break interspecies barrier zoonotic one most serious public health problems. Traditionally, peculiar attention is paid avian influenza as main reservoir source highly pathogenic strains. However, in...
Проведен анализ противовирусной активности циклоферона в отношении вируса гриппа A(H3N2)/Aichi/1/68 при моделировании in vitro на клеточных культурах MDCK и ФЛЭЧ лечебно-профилактической схемы применения препарата. Рассмотрены 2 концентрации препарата (50 100 мкг/мл), во временных точках экспозиции культурах: одномоментно с внесением A(H3N2), через 4 24 ч после заражения. Множественность заражения составила 0,01 MOI/TCID50 клетку. следующие показатели: титры гемагглютинина, уровень...
This study compared the efficacy of different therapies for ARVI during COVID-19 pandemic. Objective. To compare clinical Cycloferon and Ingavirin in children aged 4–17 years treated outpatient facilities epidemic season СOVID-19. Patients methods. included 101 patients who provided 143 oro- nasopharyngeal swabs tested using certified PCR tests. Of them, 128 samples (89.5%) were positive, whereas 15 (10.5%) negative. We identified most common viruses circulating January–May 2021, including...
Введение. Сочетанная патология острых респираторных инфекций с желудочно-кишечными расстройствами высокоактуальна. Работ по изучению роли вирусов и кишечных патогенов при одновременном исследовании материала (ротоглотка кишечник) у детей крайне мало. До конца не ясна роль тех или иных сочетанном их течении. Цель исследования. Определить инфекциях в зависимости от возраста времени года пандемическом периоде инфекции COVID-19. Оценить эффективность популярных пероральных пробиотиков форме...