A5057349217- Chalcogenide Semiconductor Thin Films
- Quantum Dots Synthesis And Properties
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Copper-based nanomaterials and applications
- Shoulder Injury and Treatment
- Congenital heart defects research
- Tendon Structure and Treatment
- Semiconductor materials and interfaces
- Proteoglycans and glycosaminoglycans research
- Ear Surgery and Otitis Media
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
- Advanced Semiconductor Detectors and Materials
- Nasal Surgery and Airway Studies
- Bone fractures and treatments
- Nerve Injury and Rehabilitation
- Orthopedic Infections and Treatments
Medizinische Hochschule Hannover
2015-2025
University Medical Center Hamburg-Eppendorf
2024
Universität Hamburg
2024
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2013
Centrotherm Photovoltaics (Germany)
2009-2011
Justus-Liebig-Universität Gießen
2008-2009
Kerckhoff Klinik
2003-2009
Max Planck Society
2008
Institut für Solarenergieforschung
1999-2000
Centre National de la Recherche Scientifique
1995-1999
For healing of critically sized bone defects, biocompatible and angiogenesis supporting implants are favorable. Murine osteoblasts showed equal proliferation behavior on the polymers poly-ε-caprolactone (PCL) poly-(3-hydroxybutyrate)/poly-(4-hydroxybutyrate) (P(3HB)/P(4HB)). As vitality was significantly better for PCL, it chosen as a suitable coating material further experiments. Titanium with 600 µm pore size were evaluated found to be good implant bone, primary onto comparable well bottom...
The role of CD44 in progression head and neck squamous cell carcinoma (HNSCC) has been controversial. goal this study was to the effects CD44(+) tumor cells on initial stages angiogenesis evaluate as a potential marker angiogenesis. gene expression studied using Cancer Genome Atlas (TCGA) Head Neck data base. Expression levels microvascular density (MVD) markers were assessed by immunohistochemistry performed with tissue microarrays cohort 49 HNSCC patients, 11 patients dysplasia 12 control...
To improve well-known titanium implants, pores can be used for increasing bone formation and close bone-implant interface. Selective Laser Melting (SLM) enables the production of any geometry was implant with 250-µm pore size. The size supports vessel ingrowth, as is strongly dependent on fast vascularization. Additionally, proangiogenic factors promote functionalize factors, polycaprolactone (PCL) coating used. following were examined: vascular endothelial growth factor (VEGF), high...
Recent evidence suggests a subset of cells within tumor with "stem-like" characteristics. These are able to transplant tumors in immunodeficient hosts. Distinct from non-malignant stem cells, cancer (CSC) show low proliferative rates, high self-renewing capacity, propensity differentiate into actively proliferating and resistance chemotherapy or radiation. They often characterized by elevated expression cell surface markers, particular CD133, sets differentially expressed cell-associated...
Biological factors such as TGF–β3 are possible supporters of the healing process in chronic rotator cuff tears. In present study, electrospun chitosan coated polycaprolacton (CS–g–PCL) fibre scaffolds were loaded with and their effect on tendon was compared biomechanically histologically to unloaded a defect rat model. The biomechanical analysis revealed that tendon–bone constructs had significantly lower values for maximum force native tendons. Tendon-bone TGF–β3-loaded showed only slightly...
Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates expression integrins alpha 5 beta 1 v 3 as well focal adhesion kinase (FAK) phosphorylated FAK (pY397), key mediators for cell migration proliferation, in collateral vessels (CV) rabbit hind limbs induced by femoral ligation or an arteriovenous (AV) shunt created between distal artery stump...
Abstract Adequate vascularization of tissue‐engineered constructs remains a major challenge in bone grafting. In view this, we loaded ß‐tricalcium‐phosphate (ß‐TCP) and porous poly( L ‐lactide‐ co ‐glycolide) (PLGA) scaffolds via collagen coating with vascular endothelial growth factor (VEGF) studied whether the VEGF loading improves scaffold angiogenesis vascularization. Dorsal skinfold chambers were implanted into 48 balb/c mice, which assigned to 6 groups ( n = 8 each). Uncoated...
Degradable implant material for bone remodeling that corresponds to the physiological stability of has still not been developed. Promising degradable materials with good mechanical properties are magnesium and alloys. However, excessive gas production due corrosion can lower biocompatibility. In present study we used polymer coating polycaprolactone (PCL), intended rate magnesium. Additionally, improvement geometry increase remodeling. Porous structures known support vessel ingrowth thus...
In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears a common cause of shoulder pain disability among adults. The development graft materials for bridging the gap between tendon bone after chronic rotator essentially limiting factor clinical success tissue engineering construct fast complete vascularization construct. Otherwise, immigrating cells not able to survive longer period time,...
Epitaxial (111) CdTe films have been grown on (1̄ 1̄ 1̄) InP single crystals by one step electrodeposition in aqueous acidic solution, at a temperature of 85 °C, and growth rate about 0.7 μm h−1. Reflexion high-energy electron diffraction five-circle x-ray techniques used to characterize the interface structure epitaxial quality. The epitaxy (fcc a=6.49 Å) takes place with direct continuation lattice a=5.87 Å), no rotation respective crystallographic directions. is markedly improved when...
Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The mobility group A2 (HMGA2) protein was found to be highly expressed human OSCC its expression suggested act as useful predictive prognostic tool clinical management carcinomas. Herein HMGA2 sister gene HMGA1 were analysed within canine samples. Additionally, HMGA negatively regulating miRNAs let-7 family well Lin28 also comparatively analysed. Deregulations either one these...
<title>Abstract</title> <bold>Background:</bold> Peri-implant health depends on the complex interactions between dental implant, surrounding soft/hard tissues and oral microbial environment. However, existing 2D monoculture models fail to replicate this complexity, limiting their clinical relevance. Therefore, study aimed develop a clinically relevant 3D <italic>in vitro</italic> model that integrates soft tissue, hard tissue titanium implant in setup accurately peri-implant In addition, was...
Arteriogenesis or collateral growth is able to compensate for the stenosis of major arteries. Using differential display RT-PCR on growing and quiescent arteries in a rabbit femoral artery ligation model, we cloned full-length cDNA osteoglycin/mimecan. Osteoglycin was present adventitia as glycosylated protein without keratan sulfate side chains, mainly produced by smooth muscle cells (SMCs) perivascular fibroblasts. Northern blot, Western immunohistochemistry confirmed artery-specific...
Various diseases, injuries, and congenital abnormalities may result in degeneration loss of organs tissues. Recently, tissue engineering has offered new treatment options for these common, severe, costly problems human health care. Its application is often based on the usage differentiated stem cells. However, despite intensive research growing knowledge, many questions remain unresolved process cell differentiation. The aim this study was to find standardized models analyzing molecular...
Acute and chronic rotator cuff tears remain challenging for therapy. A wide range of therapeutic approaches were developed but re-tears postoperative complications occur regularly. Especially in elderly people, the natural regeneration processes are decelerated, graft materials often necessary to stabilize tendon-to-bone attachment improve healing process. We here investigated a small animal model newly electrospun polycaprolactone fiber implant coated with chitosan-polycaprolactone...