A5040946773- Extracellular vesicles in disease
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Ophthalmology and Eye Disorders
- Tracheal and airway disorders
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Synthesis and Biological Evaluation
- Venous Thromboembolism Diagnosis and Management
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Synthesis and biological activity
- Thyroid Disorders and Treatments
- Synthesis of Organic Compounds
Medical University of Warsaw
2017-2024
The role of CD44 in progression head and neck squamous cell carcinoma (HNSCC) has been controversial. goal this study was to the effects CD44(+) tumor cells on initial stages angiogenesis evaluate as a potential marker angiogenesis. gene expression studied using Cancer Genome Atlas (TCGA) Head Neck data base. Expression levels microvascular density (MVD) markers were assessed by immunohistochemistry performed with tissue microarrays cohort 49 HNSCC patients, 11 patients dysplasia 12 control...
Abstract Transforming growth factor β (TGFβ) is a major component of tumor‐derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ + TEX to promote tumor and pro‐tumor activities the microenvironment (TME) are largely unknown. produced head neck squamous cell carcinoma (HNSCC) lines carried angiogenesis‐promoting proteins. stimulated macrophage chemotaxis without notable M1/M2 phenotype shift reprogrammed primary human macrophages pro‐angiogenic...
Abstract Head and neck squamous cell carcinomas (HNSCCs) evade immune responses through multiple resistance mechanisms. Extracellular vesicles (EVs) released by the tumor interacting with cells induce dysfunction contribute to progression. This study evaluates clinical relevance impact on anti-tumor of gene signatures expressed in HNSCC associated EV production/release. Expression levels two recently described sets were determined The Cancer Genome Atlas Neck cohort (n = 522) validated...
e18067 Background: Hypoxia characterizes solid tumors and results in increased tumor resistance. Head neck squamous cell carcinoma (HNSCC) hypoxic areas despite new treatment modalities high recurrence level. interferes glycosylation modifications. In previous study we demonstrated that hypoxia induces release of small extracellular vesicles (sEVs) by cells. Specific sEV profiles were found to be distinct cancer, but not have been studied HNSCC yet. Methods: lines FaDu, PCI-30, SCC-25 normal...
Abstract Exosomes, belonging to the group of extracellular bodies, are released by healthy as well cancerous cells and serve a communication pathway. Tumor-derived exosomes (TEX) possess capacity reprogram function normal owing their genetic molecular cargo. Such target endothelial (among others) in tumor microenvironment promote angiogenesis. Blood supply is essential solid growth metastasis. The potential pro-angiogenic changes enhanced an increased amount circulating tumor-derived body...
Abstract Background There is growing evidence that obstructive sleep apnea (OSA) promotes vascular endothelial dysfunction and atherogenesis. Pathways mediate this pathology may include Toll-like receptors (TLRs) receptor for advanced glycation end products (RAGE) which play a significant role in proinflammatory processes. The aim of study was to measure the expression above-mentioned relation OSA severity carotid plaques obtained during open endarterectomy. Methods This prospective included...
Tissue hypoxia is commonly observed in head and neck squamous cell carcinomas (HNSCCs), resulting molecular functional alterations of the tumor cells. The aim this study was to characterize tumor-derived small extracellular vesicles (sEVs) released under hypoxic vs. normoxic conditions analyze their proteomic content. HNSCC cells (FaDu, PCI-30, SCC-25) HaCaT keratinocytes were cultured 21, 10, 5, 1% O2. sEVs isolated from supernatants using size exclusion chromatography (SEC) characterized...
Angiogenesis, the formation of new blood vessels, plays a crucial role in progression and metastasis various cancers, including head neck squamous cell carcinoma (HNSCC). HNSCCs are characterized by altered levels angiogenesis-related factors, overexpression pro-angiogenic factors such as vascular endothelial growth factor (VEGF) platelet-derived (PDGF), well dysregulation angiogenesis inhibitors. Together, these drive vessels within tumor microenvironment considered therapeutic targets...
Graves’ ophthalmopathy (GO) is a chronic autoimmune inflammatory disorder involving orbital tissues. A receptor for advanced glycation end products (RAGE) and its ligand high mobility group box 1 (HMGB1) protein trigger inflammation cell proliferation are involved in the pathogenesis of various diseases. This study was aimed to evaluate RAGE HMGB1 expression GO determine potential clinical significance. To best our knowledge, this first showing tissue using immunohistochemistry. Sections...
A chronic inflammatory process characteristic of obstructive sleep apnea promotes vascular endothelial dysfunction and atherogenesis. This can lead to destabilization rupture cardiovascular plaques, which clinically manifests as an acute coronary syndrome or stroke. The aim this study was investigate the pathway leading plaque in non-to-mild moderate-to-severe groups OSA patients. prospective involved enrollment patients scheduled for endarterectomy. performed prior surgery....
Cholesteatoma is a specific medical condition involving the abnormal, non-cancerous growth of skin-like tissue in middle ear, potentially leading to collection debris and even infections. The receptor for advanced glycation (RAGE) its ligand, high-mobility box 1 (HMGB1), are both known be overexpressed cholesteatoma play potential role pathogenesis disease. In this study, we investigated small extracellular vesicles (sEVs) carrying HMGB1 inducing disease-promoting effects cholesteatoma. No...