A5005116471- Epilepsy research and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Traumatic Brain Injury Research
- Child Nutrition and Feeding Issues
- Cancer-related cognitive impairment studies
- Cardiac Arrest and Resuscitation
- Sports Performance and Training
- Parkinson's Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Children's Physical and Motor Development
- Cerebrospinal fluid and hydrocephalus
- Breastfeeding Practices and Influences
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Infant Development and Preterm Care
- Infant Health and Development
Hong Kong Polytechnic University
2019-2025
Universidade Federal de Santa Catarina
2011-2020
(1) Background: Adiponectin is an adipocyte-secreted hormone that has antidepressant- and anxiolytic-like effects in preclinical studies. Here, we investigated the of sub-chronic treatment with AdipoRon, adiponectin receptor agonist, its potential linkage to changes hippocampal adult neurogenesis synaptic plasticity. (2) Methods: Different cohorts wild-type C57BL/6J CamKIIα-Cre male mice were treated (7 days) followed by behavioral, molecular, electrophysiological experiments. (3) Results:...
Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally. Physical exercise, as an effective strategy for improving general health, has been largely reported its effectiveness in slowing neurodegeneration increasing brain functional plasticity, particularly aging brains. However, underlying mechanisms exercise cognitive remain unclear. Adiponectin, cell-secreted protein hormone, recently found to regulate synaptic plasticity mediate...
Abstract Background Major depressive disorder (MDD) is one of the leading causes disability worldwide (Kessler et al., 2003). Despite rapid-acting antidepressants ketamine elicits rapid and sustained antidepressant effects, chronic use side effects like addiction or hallucinogenic(Smith-Apeldoorn 2022). Emerging clinical studies have demonstrated onset single-bout physical exercise (Brush 2021, Ge 2021). However, neural mechanisms underlying this action not been identified. Aims &...
Abstract Background Depression is a pervasive disease and worldwide health challenge 1. First-line antidepressants have delayed therapeutic onset low remission rates 2,3, while rapid-acting (e.g., ketamine) psychomimetic side effects that hinder their widespread use 4. Adiponectin an adipocyte-related hormone has been implicated in depression 5 shown to elicit rapid antidepressant pre-clinical studies 6. Despite its promise as target treatment 7–9, adiponectin properties not tested animal...
<title>Abstract</title> Maternal physical activity during pregnancy has been shown to confer benefits on the brain functions of offspring. This study investigated positive effects maternal exercise enhancing hippocampal synaptic plasticity and resilience stress-induced depressive behavior in adult murine Using a mouse model with mother mice engaged voluntary wheel running pregnancy, we assessed changes long-term potentiation (LTP) dentate gyrus, protein expression, behavioral responses...
<title>Abstract</title> Autism spectrum disorder (ASD) is characterized by early-onset challenges in social communication and repetitive behaviors, influenced both genetic environmental factors. The global increase ASD diagnoses has drawn attention to air pollution as a significant risk factor, although the underlying mechanisms remain unclear. This study investigates impact of maternal exposure pollutant PM<sub>2.5 </sub>on offspring. In this study, female C57BL/6J mice were exposed...
Research suggests that maternal exercise in pregnancy may have beneficial effects on the brain function of offspring. This study sought to determine if voluntary wheel running during improves depression-like behavior, temporal order memory, and hippocampal neurogenesis both female male offspring mice. Pregnant mice were allowed run voluntarily by introducing wheels into housing cages throughout gestational period. Male at age 8- 9-week-old then tested task forced swim test, euthanized for...
Objectives Traumatic brain injury ( TBI ) is a main cause of mortality and morbidity. Association studies between hospitalization variables cognitive impairment after are frequently retrospective, including non‐consecutive patients showing variable degrees severity, poor management missing (drop out) cases. Methods We assessed prospectively the demographic 234 consecutive with severe (admission G lasgow C oma S cale [ GCS ] ≤8) determined their independent association performance in...
(1) Objectives: Epilepsy disorder is likely to increase with aging, leading an increased incidence of comorbidities and mortality. In spite that, there a lack information regarding this issue little knowledge cognitive emotional responses in aging subjects following epileptogenesis. We investigated whether how distress epilepsy-related behavioral biochemical outcomes are associated cognition emotion. (2) Methods: Young middle-aged Wistar rats (3 or 12 months old) were treated...
Chemotherapy-induced cognitive impairment (chemobrain) and muscle wasting (cachexia) are persisting side effects which adversely affect the quality of life cancer survivors. We therefore investigated efficacy physical exercise as a non-pharmacological intervention to reverse adverse chemotherapy. examined whether in terms voluntary wheel running could prevent chemotherapy-induced motor impairments mice treated with multi-kinase inhibitor sorafenib. Adult male BALB/c were subdivided into...
Polyunsaturated fatty acids (PUFAs) play an essential role in brain development. Emerging data have suggested a possible link between imbalance PUFAs and cognitive behavioral deficits offspring. A diet rich high linoleic acid (HLA), typically from preconception to lactation, leads increase the ratio of omega-6 (n-6) omega-3 (n-3) fetus. Arising research has that deficiency is potential risk factor for inducing autism spectrum disorder (ASD)-like deficits. However, impact n- during...
Cognitive impairment is inherent to the ageing process. Several studies suggest that patients with late-life schizophrenia have more marked cognitive impairment.The aim of this study was compare performance elderly institutionalized and control without neurological or psychiatric diseases, matched for age, educational level institutionalization time.The Cambridge Examination Mental Disorders Elderly (CAMCOG) used test 10 schizophrenia. Results were compared those history Hansen's...