A5031633331- Ginger and Zingiberaceae research
- Telomeres, Telomerase, and Senescence
- Platelet Disorders and Treatments
- Essential Oils and Antimicrobial Activity
- Advanced Breast Cancer Therapies
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytochemicals and Antioxidant Activities
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Edible Oils Quality and Analysis
- Cancer-related Molecular Pathways
- Sesquiterpenes and Asteraceae Studies
- Antimicrobial agents and applications
- Insect Pest Control Strategies
- Computational Drug Discovery Methods
- Cardiac Ischemia and Reperfusion
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Medicinal Plants
- Free Radicals and Antioxidants
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Cytomegalovirus and herpesvirus research
Catholic University of the Maule
2024-2025
University of Talca
2019-2023
Instituto Venezolano de Investigaciones Científicas
2014-2018
Atrial fibrillation (AF) involves electrical remodeling of the atria, with ion channels such as NaV1.5, KV1.5, and TASK-1 playing crucial roles. This study investigates acetamide-based compounds designed multi-target inhibitors these to address AF. Compound 6f emerged most potent in series, demonstrating a strong inhibition (IC50 ∼0.3 μM), moderate NaV1.5 ∼21.2 μM) subtle KV1.5 ∼81.5 alongside unexpected activation TASK-4 (∼40% at 100 μM). Functional assays on human atrial cardiomyocytes...
Aging is one of the main risk factors for development chronic diseases, with both vascular endothelium and platelets becoming functionally altered. Cellular senescence a form permanent cell cycle arrest initially described in primary cells propagated vitro, although it can also be induced by anticancer drugs other stressful stimuli. Attesting complexity senescent phenotype, synthesize secrete wide variety bioactive molecules. This “senescence-associated secretory phenotype” (SASP) endows...
Alterations in platelet aggregation are common aging individuals and the context of age-related pathologies such as cancer. So far, however, effects senescent cells on platelets have not been explored. In addition to serving a barrier tumor progression, cellular senescence can contribute remodeling tissue microenvironments through capacity synthesize secrete plethora bioactive factors, feature referred senescence-associated secretory phenotype (SASP). As accumulate tissues, sites injury, or...
Three new lupane-type triterpenoids: 6β,30-dihydroxybetulinic acid glucopyranosyl ester (4), (5) and 6β-hydroxybetulinic (6), were isolated from Licania cruegeriana Urb. along with six known compounds. Their structures elucidated on the basis of spectroscopic methods, including IR, ESIMS, 1D- 2D-NMR experiments, as well by comparison their spectral data those related All compounds evaluated in vivo for effects mean arterial blood pressure (MABP) heart rate (HR) spontaneously hypertensive...
Pyrogallol is a polyphenol that generates the superoxide anion. In this study, we investigated influence of pyrogallol on human platelets. Our data showed exposure platelets to induced numerous manifestations apoptosis including depolarization mitochondrial inner membrane and release cytochrome c from mitochondria. also downstream extra-mitochondrial apoptotic responses, activation caspase-3 phosphatidylserine outer leaflet plasma membrane. Addition glutathione significantly rescued cells...
Lipid oxidation is the major cause of deterioration fat-containing foods, especially those containing polyunsaturated fatty acids (PUFAs). Antioxidant additives synthetic origin are added to matrices rich in PUFAs, such as sunflower oil (SO). However, there controversy regarding their safety, and low solubility both water fat has led search for new covalent modifications through lipophilicity. This work presents synthesis O-alkyl acid derivatives from ferulic syringic study antioxidant...
Pyrogallol is a polyphenol that generates the superoxide anion. In this study, we investigated influence of pyrogallol on human platelets. Our data showed exposure platelets to induced numerous manifestations apoptosis including depolarization mitochondrial inner membrane and release cytochrome c from mitochondria. also downstream extra-mitochondrial apoptotic responses, activation caspase-3 phosphatidylserine outer leaflet plasma membrane. Addition glutathione significantly rescued cells...
Despite not dividing, senescent cells acquire the ability to synthesize and secrete a plethora of bioactive molecules, feature known as senescence-associated secretory phenotype (SASP). In addition, often upregulate autophagy, catalytic process that improves cell viability in stress-challenged cells. Notably, this "senescence-related autophagy" can provide free amino acids for activation mTORC1 synthesis SASP components. However, little is about functional status models senescence induced by...
Hedychium coronarium J. Koening, belonging to Zingiberaceae family, is a perennial herb with fleshly aromatic rhizomes. There are no information about the antiplatelet properties of essential oils (EOs) from rhizomes (HCR) and leaves (HCL) this herb, additionally, there reports antibacterial activity species, however, studies have been carried out in Colombian Amazon Region. The EOs were characterized by GC-MS, antiaggregant was assessed ADP Collagen as platelet agonist against E. faecalis...
Cardiovascular diseases (CVDs) remain leading causes of death worldwide. While platelet-mediated thrombus formation following the rupture an atherosclerotic plaque is one key pathophysiologic events in CVDs, role platelets previous or more advanced stages atherosclerosis less known. Interestingly, presence has been observed at core plaque.In order to study conditions necessary for migrate toward lesion, we designed vitro co-culture model. Platelets were co-cultured with monocytes Transwell...
Abstract Introduction: The initial transition from a proliferative to senescent state is accompanied by reduction in the activity of cyclin-cyclin-dependent kinase (CDK) complexes, which turn could be explained activation p53-p21CIP1/WAF1 and/or p16INK4a-pRB signaling pathways. As overexpression D-type cyclins commonly observed gastric cancer cells, use CDK4/6 inhibitors represent viable alternative for treatment. Nonetheless, cell can synthesize and secrete plethora bioactive molecules (a...