A5046772608- Contact Dermatitis and Allergies
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Bioactive Compounds and Antitumor Agents
- Allergic Rhinitis and Sensitization
- Pesticide Exposure and Toxicity
- Inhalation and Respiratory Drug Delivery
- Phenothiazines and Benzothiazines Synthesis and Activities
- Adsorption and biosorption for pollutant removal
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Nail Diseases and Treatments
- Analytical Methods in Pharmaceuticals
- Cellular transport and secretion
- Advanced biosensing and bioanalysis techniques
- Corneal Surgery and Treatments
- Bee Products Chemical Analysis
- Arsenic contamination and mitigation
- DNA and Nucleic Acid Chemistry
- Ocular Surface and Contact Lens
- Pesticide Residue Analysis and Safety
- Metallurgy and Cultural Artifacts
Universität Trier
2016-2025
Technische Universität Braunschweig
2018
Bayer (Germany)
2018
Médecins Sans Frontières
2004-2012
Across (Spain)
2011
Saarland University
1995-1998
A formal validation study was performed, in order to investigate whether the commercially-available reconstructed human epidermis (RHE) models, EPISKIN®, EpiDerm™ and SkinEthic®, are suitable for vitro skin absorption testing. The types currently recommended OECD Test Guideline 428, namely, ex vivo pig skin, were used as references. Based on promising outcome of prevalidation study, panel test substances enlarged nine substances, covering a wider spectrum physicochemical properties. tested...
Exposure to chemicals absorbed by the skin can threaten human health. In order standardise predictive testing of percutaneous absorption for regulatory purposes, OECD adopted guideline 428, which describes methods assessing using and animal skin. this study, a protocol based on principles was developed prevalidated reconstructed epidermis (RHE). The permeation standard compounds, caffeine testosterone, through commercially available RHE models compared that comparison epidermis,...
The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) formed to certain extents. Skin frequently in contact with PAHs and data on metabolic capacity skin tissue toward these compounds are inconclusive. We compared metabolism excised human skin, commercially available vitro 3D models primary 2D cell cultures, analyzed metabolically catalyzed occurrence...
In the current research work, urea-treated microwave-modified sugar cane bagasse (MSCB), an agricultural waste, is employed as low-cost adsorbent for removing Cd (II) ions from reaction media. this comparative analysis of MSCB and unmodified (USCB) were studied at same time comparison was made investigating better adsorption performance using model contaminant. Different parameters affecting removal including time, pH, dose studied. Results indicate that required less extreme conditions...
Hay fever is notoriously triggered when nasal mucosa exposed to allergenic pollen. One possibility overcome this pollen exposure may be the application of an ointment with physical protective effects. In context, we have investigated Bepanthen® Eye and Nose Ointment basis petrolatum as reference while using contemporary in vitro techniques. Pollen from false ragweed (Iva xanthiifolia) was used allergy-causing model deposited aerosol Vitrocell® Powder Chamber (VPC) on Transwell® inserts,...
Ziel der vorliegendenden In-vitro-Studien und In-vivo-Studien war es, die Permeation Penetration eines 2,5%-igen Ketoprofen (CAS 22071-15-4) Gels [Phardol® Schmerz-Gel (Test-D)] mit zweier anderer Ketoprofen-Gele (Ref-I, Ref-E) sowie Ibuprofen 15687-27-1) (Ref-D) an exzidierter Haut zu vergleichen. Außerdem wurden In-vivo-Untersu-chungen durchgeführt. Die Untersuchungen in statischen Franz-Diffusionszellen ermöglichten Bestimmung des transdermalen (systemischen) Transportes, während...
Ungual formulations are regularly tested using human nails or animal surrogates in Franz diffusion cell experiments. Membranes sometimes less than 100 µm thick used, disregarding the higher physiological thickness of and possible fungal infection. In this study, bovine hoof membranes, healthy infected with Trichophyton rubrum, underwent different imaging techniques highlighting that continuous pores traversed entire membrane infection resulted growth, both superficial, as well membrane's...
To develop in vitro methods to assess binding by sodium hyaluronate eye drops corneal surfaces.Two different, complementary set-ups were developed. In a dynamic model, confluent epithelial cells (HCE-T) assembled chamber slides and declining channel. A static model was constructed with ex vivo porcine corneas clamped Franz cells. test the predictive capacity of models, four different containing spiked tritium-labeled standardize quantification. both settings, applied for 5 min physiological...
In order to prepare for a validation study compare percutaneous absorption through reconstructed human epidermis with ex vivo skin and animal skin, nine test compounds, covering wide range of physicochemical properties were selected, namely: benzoic acid; caffeine; clotrimazole; digoxin; flufenamic ivermectin; mannitol; nicotine; testosterone. The donor receptor media the substances, addition solubiliser lipophilic as well stability solubility substances in vehicles, systematically analysed....
In vitro skin permeation experiments are highly relevant for pharmaceutical, cosmetic, agricultural developments, and regulatory evaluation. A key requirement is the barrier integrity, that accompanied by an intact stratum corneum (SC) which implements high quality. variety of integrity tests currently available, example, measurement transepidermal water loss, monitoring tritiated transdermal electrical resistance (TER).We aimed a non-destructive examination as quality control system, based...