A5101634365- Dental Health and Care Utilization
- Cleft Lip and Palate Research
- Oral microbiology and periodontitis research
- Indigenous Health, Education, and Rights
- Protease and Inhibitor Mechanisms
- Dental Education, Practice, Research
- Infective Endocarditis Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Indigenous Studies and Ecology
- Health Systems, Economic Evaluations, Quality of Life
- Trace Elements in Health
- HIV, Drug Use, Sexual Risk
- Heavy Metal Exposure and Toxicity
- Cardiac Arrest and Resuscitation
- Pharmaceutical Economics and Policy
- Alzheimer's disease research and treatments
- Traumatic Brain Injury Research
- Alcohol Consumption and Health Effects
- Oral health in cancer treatment
- Dental Research and COVID-19
- Interpreting and Communication in Healthcare
- Anesthesia and Neurotoxicity Research
- Health and Lifestyle Studies
- Neuroscience and Neuropharmacology Research
- Temporomandibular Joint Disorders
Western Sydney University
2017-2025
South Western Sydney Local Health District
2017-2025
The University of Sydney
2018-2025
Ingham Institute
2017-2025
Sydney Dental Hospital
2024
University of Central Lancashire
2018
Centre for the Study of Developing Societies
2016-2018
Amrita Institute of Medical Sciences and Research Centre
2018
UCL Australia
2018
University College London
2018
Periodontal inflammation is characterized by irreversible degradation of periodontal ligament collagen fibers leading to loss tooth attachment. Cultured gingival keratinocytes and fibroblasts express, in vitro, various matrix metalloproteinases (MMPs) which can degrade fibrillar collagens. We hypothesized that several MMPs are also synthesized vivo sulcular epithelium, analyzed the collagenolytic (MMP-2, -8, -13, -14) matrilysin (MMP-7) tissue specimens crevicular fluid from adult localized...
Objectives: Matrix metalloproteinases (MMPs) play crucial role in various tissue destructive inflammatory processes by degrading almost all peri‐cellular and basement membrane components. MMP‐8 (collagenase‐2) is the major MMP periodontitis. MMP‐7 (matrilysin‐1), addition to its ability degrade matrix components, activates other latent pro‐MMPs defensins, host cell‐derived antimicrobial cryptidins. The aim of present study was characterize relationship, levels molecular forms diseased...
The aim of this study was to explore the perception patients with cardiovascular disease towards oral health and potential for cardiac care clinicians promote health.A needs assessment undertaken twelve attending rehabilitation between 2015 2016, in three metropolitan hospitals Sydney, Australia. These participated face-to-face semi-structured interviews. Data analysed using thematic analysis.Results suggested that while considered relevant there high prevalence poor among participants,...
Matrix metalloproteinase-9 (MMP-9) has been shown to be involved in the development of diabetic nephropathy (DNP). We studied levels, molecular forms, and degree activation urinary MMP-8, -9, -14, trypsin-1 -2, as well tumor-associated trypsin inhibitor (TATI) DNP patients healthy controls.Urinary samples were analyzed for MMPs by Western blotting gelatin zymography trypsin-1, TATI time-resolved immunofluorometric assays.Total MMP-8 immunoreactivity, proportion active MMP-9, gelatinolytic...
Periodontal disease is a risk factor for atherosclerotic cardiovascular and it recommended internationally that patients with should engage in preventative oral health practices attend regular dental care visits. This study aimed to explore the status, behaviours knowledge of disease.A cross-sectional questionnaire containing 31 items was administered from cardiac rehabilitation outpatient clinics Sydney Australia 2016-2017.Of 318 surveyed, 81.1% reported having at least one problem. Over...
Background: Oral health problems are common, but often overlooked, among people receiving palliative care. Aim: To better understand how oral can be addressed in this population, study aimed to explore the perceptions of care medical practitioners who provide inform development a program. Design: A descriptive qualitative design was adopted. Setting/participants: single focus group conducted with 18 at facility Sydney, Australia. All participants had experience providing services clients....
Abstract Aim This study aimed to explore the perceptions of residential aged care nursing and management staff regarding oral care, develop strategies improve health residents. Design A qualitative approach was used. Methods Two focus groups were conducted with at two facilities transcripts thematically analysed. Results All had an awareness importance health; however, they highlighted significant challenges in current system that affect implementation training practice guidelines facility....
Abstract Introduction Alcohol and illicit drug use is linked to a higher prevalence of oral health complications. However, substance can lead avoidance dental services due anxiety competing priorities. This study explores current knowledge, attitudes practices clinicians an alcohol other service regarding promoting among their clients. Methods Exploratory qualitative design using semi‐structured interviews with medical nursing staff working as professionals in Drug Health Service South...
Human matrix metalloproteinase-20 (MMP-20, enamelysin) fragments the enamel-specific protein amelogenin and has been shown to be synthesized exclusively by odontoblasts ameloblasts in certain odontogenic tumors. Here we demonstrate, for first time, expression of MMP-20 mRNA two carcinoma cell lines originating from tongue. Treatment SCC-25 HSC-3 cells with phorbol 12-myristate 13-acetate (10 nmol/L) up-regulated up 1.6-fold, but transforming growth factor beta ng/mL) had no effect. The...
Abstract Background In Australia, models of care have been developed to train antenatal providers promote oral health among pregnant women. However, these are underpinned by Western values maternity that do not consider the cultural needs Aboriginal and Torres Strait Islander This study aimed explore perceptions experiences staff towards during pregnancy. It is part a larger program research develop new, culturally safe model for women Methods A descriptive qualitative methodology informed...
Evidence suggests that the gamma-aminobutyric acid (GABA)ergic system may be involved in cognitive dysfunction following traumatic brain injury (TBI). We investigated effect of flumazenil treatment, a benzodiazepine antagonist approved by U.S. Food and Drug Administration, on learning memory immature rat experimental injury. Post-natal day 17 rats were injured using controlled cortical impact. Systemic treatment with at 1, 5, 10 mg/kg was initiated post-injury 1 administered for 13 days via...
Pregnant women in Australia seldom seek dental care and are unaware of its importance. To address these gaps the midwifery-initiated oral health service (MIOH-DS) program was comprehensive trialled found effective. The aim this study to undertake a process evaluation MIOH-DS using perspectives pregnant who participated trial.A qualitative research design utilized, whereby content analysis undertaken on data from 11 semi-structured interviews with program.All participants were receptive...
Objectives To critically evaluate the cost-effectiveness of Midwifery Initiated Oral Health-Dental Service (MIOH-DS) designed to improve oral health pregnant Australian women. Previous efficacy and process evaluations MIOH-DS showed positive outcomes improvements across various measures. Design setting The evaluation used a cost-utility model based on initial study design trial in Sydney, Australia from perspective public healthcare provider for duration 3 months 4 years. Participants Data...
Abstract Issues Poor oral health is a significant problem among people who access alcohol and other drugs (AOD) services, yet little known about their health‐care needs whether any interventions guidelines are implemented within AOD treatment services. Approach A scoping review was conducted to identify scientific literature in three focus areas: knowledge, attitudes practices of clients clinicians at AOD‐related services; for clinicians; that describe promoting clients. Key Findings...
Objective This study aimed to look at the practices and perspectives of residential aged care facility ( RACF ) staff regarding provision oral health in s. Background Emphasis has been placed on adequate s through Better Oral Health Residential Aged Care programme. Endorsed by Australian government, this programme provided education training for staff. However, recent evidence suggests that nearly five years after implementation programme, NSW remains inadequate. Materials Methods project...
Abstract Oxidative damage to every class of biological macromolecule has been characterized in Alzheimer's disease. Abnormalities iron and copper metabolism are also being implicated as playing a crucial role neurodegenerative disease pathogenesis. Metal homeostasis it pertains alterations brain function diseases is reviewed here with its relationship oxidative stress. While there documented evidence for transition metal homeostasis, redox‐activity, localization, important realize that...