A5070774016- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Computational Drug Discovery Methods
Hebrew University of Jerusalem
2018-2023
BitterDB (http://bitterdb.agri.huji.ac.il) was introduced in 2012 as a central resource for information on bitter-tasting molecules and their receptors. The is frequently used choosing suitable ligands experimental studies, developing bitterness predictors, analysis of receptors promiscuity more. Here, we describe major upgrade the database, including significant increase content well new features. now holds over 1000 bitter molecules, up from initial 550. When available, quantitative...
Drug development is a long, expensive and multistage process geared to achieving safe drugs with high efficacy. A crucial prerequisite for completing the medication regimen oral drugs, particularly pediatric geriatric populations, taste that does not hinder compliance. Currently, aversive of tested in late stages clinical trials. This can result need reformulate, potentially resulting use more animals additional toxicity trials, increased financial costs delay release market. Here we present...
Bitterness is an aversive cue elicited by thousands of chemically diverse compounds. Bitter taste may prevent consumption foods and jeopardize drug compliance. The G protein-coupled receptors for bitter taste, TAS2Rs, have species-dependent number subtypes varying expression levels in extraoral tissues. Molecular recognition TAS2R physiologically important, presents a challenging case study ligand-receptor matchmaking. Inspired hybrid recommendation systems, we developed new set similarity...
Flavor is perceived through the olfactory, taste, and trigeminal systems, mediated by designated GPCRs channels. Signal integration occurs mainly in brain, but some cross-reactivities occur at receptor level. Here, we predict potential bitterness taste receptors targets for thousands of odorants. BitterPredict BitterIntense classifiers suggest that 3-9% flavor food odorants have bitter almost none are intensely bitter. About 14% molecules expected to an odor. Bitterness more common...
Abstract The human GPCR family comprises circa 800 members, activated by hundreds of thousands compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily, expressed orally extra-orally involved in physiological pathological conditions. TAS2R14 is the most promiscuous member, with over 150 agonists 3 antagonists known prior to this study. Due scarcity inhibitors importance chemical probes for exploring functions, we aimed discover new ligands receptor, emphasis on...
Abstract Bitterness is an aversive cue elicited by thousands of chemically diverse compounds. Bitter taste may prevent consumption foods and jeopardize drug compliance. The G protein-coupled receptors for bitter taste, TAS2Rs, have species-dependent number subtypes varying expression levels in extraoral tissues. Molecular recognition TAS2R physiologically important, presents a challenging case study ligand-receptor matchmaking. Inspired hybrid recommendation systems, we developed new set...
Abstract Drug development is a long, expensive and multistage process geared to achieving safe drugs with high efficacy. A crucial prerequisite for completing the medication regimen oral drugs, particularly pediatric geriatric populations, taste that does not hinder compliance. Currently, aversive of tested in late stages clinical trials. This can result need reformulate, potentially resulting use more animals additional toxicity trials, increased financial costs delay release market. Here...