A5024538104- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
Hebrew University of Jerusalem
2022-2024
Hebrew College
2024
Abstract A large portion of the human GPCRome is still in dark and understudied, consisting even entire subfamilies GPCRs such as odorant receptors, class C orphans, adhesion GPCRs, Frizzleds taste receptors. However, it undeniable that these bring an untapped therapeutic potential should be explored further. Open questions on span diverse topics deorphanisation, development tool compounds tools for studying well understanding basic signalling mechanisms. This review gives overview current...
Abstract Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled (GPCRs) expressed orally and extraorally, elicit signaling in response to large set ligands. Among the 25 functional TAS2Rs encoded human genome, TAS2R14 is most promiscuous, responds hundreds chemically diverse agonists. Here, we present cryo–electron microscopy (cryo-EM) structure (hTAS2R14) complex with its cognate partner gustducin, bound flufenamic acid (FFA), clinically approved nonsteroidal anti-inflammatory...
Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled (GPCRs) expressed orally and extraorally, elicit signaling in response to large set tastants. Among 25 functional TAS2Rs encoded the human genome, TAS2R14 is most promiscuous, responds hundreds chemically diverse ligands. Here we present cryo–electron microscopy (cryo-EM) structure complex with its partner gustducin, bound flufenamic acid (FFA), clinically approved nonsteroidal anti-inflammatory drug. The reveals an unusual...
Abstract The human GPCR family comprises circa 800 members, activated by hundreds of thousands compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily, expressed orally extra-orally involved in physiological pathological conditions. TAS2R14 is the most promiscuous member, with over 150 agonists 3 antagonists known prior to this study. Due scarcity inhibitors importance chemical probes for exploring functions, we aimed discover new ligands receptor, emphasis on...