A5044794391- Hormonal and reproductive studies
- Prostate Cancer Treatment and Research
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Estrogen and related hormone effects
- Photoreceptor and optogenetics research
- Reproductive tract infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Sperm and Testicular Function
- Cervical Cancer and HPV Research
- Prostate Cancer Diagnosis and Treatment
- Escherichia coli research studies
- Effects and risks of endocrine disrupting chemicals
- Xenotransplantation and immune response
- Stress Responses and Cortisol
- Growth Hormone and Insulin-like Growth Factors
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
University of Miami
2022-2023
Sylvester Comprehensive Cancer Center
2022-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2020
Instituto de Investigaciones en Ciencias de la Salud
2016-2020
Universidad Nacional de Córdoba
2012-2020
Neutrophils are major effectors of acute inflammation against infection and tissue damage, with ability to adapt their phenotype according the microenvironment. Although sex hormones regulate adaptive immune cells, which explains differences in immunity infection, little information is available about effects androgens on neutrophils. We therefore aimed examine neutrophil recruitment plasticity androgen-dependent -independent sites under androgen manipulation. By using a bacterial model...
Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of homeostasis, alterations which are a central aspect development pathological conditions. Testosterone can act through classic androgen receptor (AR) cytoplasm, eliciting genomic signaling, or different types receptors located at plasma membrane nongenomic signaling. We aimed to find evidence testosterone-signaling mechanisms pSMCs and their participation cell proliferation, differentiation,...
Candida albicans is the prevalent etiological agent in acute vulvovaginal infection and most severe chronic condition known as recurrent candidiasis (VVC). A critical role of local innate immunity defense pathogenesis vaginal by proposed. The fungal recognition immune receptor an essential step for induction responses including cytokines antimicrobial peptides (AMPs) production host protection. Using TLR2-deficient mice, we characterized early response during VVC. Intravaginal challenge...
Prostatic smooth muscle cells (pSMCs) differentiation is a key factor for prostatic homeostasis, with androgens exerting multiple effects on these cells. Here, we demonstrated that the myodifferentiator complex Srf/Myocd up‐regulated by testosterone in dose‐dependent manner primary cultures of rat pSMCs, which was associated to increase Acta2 , Cnn1 and Lmod1 expressions. Blocking Srf or Myocd siRNAs inhibited effect testosterone. While LPS led dedifferentiated phenotype characterized...
Androgen deprivation therapy (ADT) is the longstanding treatment for advanced prostate cancer (PC) because androgen receptor (AR) key therapeutic vulnerability this disease. Bipolar (BAT) - rapid cycling of supraphysiologic (SPA) and low serum testosterone levels an alternative concept, but not all patients respond acquired resistance can occur. In issue JCI, Sena et al. developed a gene signature indicative high AR activity to predict patient response BAT, including decline in both...
Event Abstract Back to Effect of testosterone on the activity inflammatory cells Amado Quintar1, 2*, Carolina Leimgruber1, Nahuel Peinetti1 and Cristina Maldonado1 1 Universidad Nacional de Cordoba, Centro Microscopía Electrónica, Facultad Ciencias Médicas, Argentina 2 INICSA-CONICET, Immunomodulation by sex hormones have both physiological pathological implications in several processes. However, role androgens controlling response is just begun be dissected. Our initial goal was analyze...
Supplementary Figure from Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin Signaling Axis by Repurposing Vaptans
Supplementary Figure from Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin Signaling Axis by Repurposing Vaptans
Abstract Background: Men with incurable castration resistant prostate cancer (CRPC) are typically treated taxanes; however, drug resistance rapidly develops. Thus, overcoming taxane PC is a major clinical need. We previously identified seven gene network in aggressive CRPC, which includes the mitotic serine threonine kinase BUB1 , regulator of spindle assembly checkpoint (SAC). Alterations kinases (and SAC malfunction) associated advanced and development thereby represent potential...
<div>Abstract<p>Men with advanced prostate cancer are treated by androgen deprivation therapy but the disease recurs as incurable castration-resistant (CRPC), requiring new treatment options. We previously demonstrated that G protein–coupled receptor (GPCR) arginine vasopressin type1A (AVPR1A) is expressed in CRPC and promotes growth <i>in vitro</i> vivo</i>. AVPR1A part of a family GPCR's including type 2 (AVPR2). Interrogation patient sample data revealed...
<div>Abstract<p>Men with advanced prostate cancer are treated by androgen deprivation therapy but the disease recurs as incurable castration-resistant (CRPC), requiring new treatment options. We previously demonstrated that G protein–coupled receptor (GPCR) arginine vasopressin type1A (AVPR1A) is expressed in CRPC and promotes growth <i>in vitro</i> vivo</i>. AVPR1A part of a family GPCR's including type 2 (AVPR2). Interrogation patient sample data revealed...
Los andrógenos suprimen las defensas del huésped a través de múltiples mecanismos la inmunidad adaptativa; sin embargo, existe escasa evidencia sobre su acción en respuesta inflamatoria temprana dominada por neutrófilos. Nuestro objetivo fue evaluar el efecto testosterona reclutamiento y fenotipo neutrófilos sitios andrógeno-dependientes e independientes.Ratas Wistar macho adultas fueron orquiectomizadas inmediatamente tratadas con dosis fisiológica (T) o vehículo (OX). La próstata ventral...