No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2002CANCER CONTROL WITH RADICAL PROSTATECTOMY ALONE IN 1,000 CONSECUTIVE PATIENTS GERALD W. HULL, FARHANG RABBANI, FARHAT ABBAS, THOMAS M. WHEELER, MICHAEL KATTAN, and PETER T. SCARDINO HULLGERALD HULL More articles by this author , RABBANIFARHANG RABBANI ABBASFARHAT ABBAS WHEELERTHOMAS WHEELER Financial interest and/or other relationship with Astra Zeneca Pharmaceuticals. KATTANMICHAEL KATTAN SCARDINOPETER View All Author...

We analyzed the long-term progression-free probability after radical retropubic prostatectomy in a consecutive series of patients with localized prostate cancer.From 1983 to 1998, 1,000 (median age 62.9 years, range 37.7 81.4) clinical stage T1 T2 cancer were treated and pelvic lymphadenectomy, without other related therapy before recurrence. Mean followup was 53.2 months 46.9, 1 170).Ten years mean +/- 2 standard errors that remained free progression any further treatment 75.0% 3.7%...

Species distribution modelling (SDM) is an important tool to examine the possible change in population range and/or niche-shift under current environment and predicted climate change. Monotheca buxifolia economically ecologically tree species inhabiting Pakistan Afghanistan dense patches, contracting rapidly. This study hypothesize that might remarkably influence existing pattern of M. area. A total 75 occurrence locations were identified comprising as a dominant species. The Maximum Entropy...

The importance of immuno-histological detection neuroendocrine differentiation in prostatic adenocarcinoma with respect to disease at presentation and Gleason grade is gaining acceptance. There limited literature on the relative significance three commonly used markers NE i.e. Chromogranin A (CgA), Neuron specific enolase (NSE) Synaptophysin (Syn). In current work we have assessed correlation determine value various markers. Consecutive samples malignant specimens (Transurethral resection...

Abnormal placental penetration through the myometrium with bladder invasion is a rare obstetric complication potential for massive blood loss. Urologists are usually consulted after life threatening emergency has already arisen. Their familiarity this condition crucial effective management. We describe 2 cases of placenta percreta to highlight catastrophic nature clinical entity, and review literature on current diagnostic management strategies.Between 1986 1998, 250 adherent (0.9%) were...

As a response to changing operating environment, healthcare administrators are implementing modern management tools in their organizations. The balanced scorecard (BSC) is considered viable tool high-income countries improve hospital performance. BSC has not been applied settings low-income nor the context for implementation examined. This study explored contextual perspectives relation Pakistani hospital. Four clinical units of this were involved based on willingness participate....

Abstract Purpose To investigate the promoter methylation status at selected loci which encode for key proteins involved in apoptosis, DNA repair, cell cycle control and progression urothelial carcinoma of bladder compare findings from tissue samples with that plasma. Methods Total genomic was isolated 43 non-muscle invasive (low grade) 33 muscle (high cancer along 10 cases normal mucosa. Promoter investigated RASSF1A , APC MGMT CDKN2A CDKN2B genes using real-time methylation-specific PCR...

The aim of this study was to examine the course time-dependent evolution HIV-1 subtype A on a global level, especially with respect dynamics immunogenic HIV gag epitopes.We used total 1,893 sequences representing timeline from 1985 through 2010, and 19 different countries in Africa, Europe Asia. phylogenetic relationship its epidemic analysed Maximum Likelihood tree Bayesian Skyline plot, genomic variability measured terms G → substitutions Shannon entropy, epitopes examined. Finally,...

Abstract The pathophysiology of prostate cancer involves both genetic and acquired factors, including pathogens, such as viruses. A limited number studies have shown the presence Epstein-Barr virus (EBV) in tissues. However, there is a dearth data exploring EBV latency profile cancer, relationship with histopathological features cancer. In this study, benign prostatic hyperplasia (BPH) samples were screened for EBV, followed by characterization analysis parameters EBV-positive EBV-negative...

Objective: To determine the frequency of patients who need below knee amputation after conservative management presenting in tertiary care hospital Pakistan. Study Design: Observational Cross-sectional study. Setting: Azra Naheed Medical College/CMA Teaching and Research Hospital Lahore Period: One year from 31st March 2022 to 28th February 2023. Methods: After approval Institutional review board medical College, sample was raised using non-convenience probability sampling. Sample size 145...

Recent reports on acetylcholine muscarinic receptor subtype 3 (CHRM3) have shown its growth-promoting role in prostate cancer. Additional studies report the proliferative effect of cholinergic agonist carbachol cancer by agonistic action CHRM3. This study shows that type 1 (CHRM1) contributes toward proliferation and growth We used cytotoxic assays, microarray database CHRM downstream pathways' homology subtypes to uncover multiple signals leading Growth assays showed pilocarpine stimulates...

1. The pharmacology of bimatoprost, a synthetic prostaglandin-amide, was examined in prostaglandin F(2alpha) (PGF(2alpha))-sensitive preparations. Bimatoprost potently contracted the rabbit isolated uterus (pEC(50)=7.92+/-0.16). In contrast, bimatoprost exhibited weak excitatory activity human myometrium from pregnant and nonpregnant donors, mouse uterus, rat endothelium-intact jugular veins, did not stimulate DNA synthesis fibroblasts. 2. possibility that effects may reflect partial agonism...

Aberrations in DNA methylation patterns promote changes gene expression and are invariably associated with neoplasia. is carried out maintained by several methyltransferases (DNMTs) among which DNMT1 functions as a maintenance methylase while DNMT3a 3b serve de novo enzymes. Although DNMT3b has been shown to preferentially target the of sequences residing pericentric heterochromatin whether it involved specific remains an open question. To address this issue, we have silenced...

Abstract Balanced Scorecards (BSC) are being implemented in high income health settings linking organizational strategies with performance data. At this private university hospital Pakistan an elaborate information system exists. This study aimed to make best use of available data for better management. Applying the modified Delphi technique expert panel clinicians and managers reduced a long list indicators manageable size. Indicators from existing documents were evaluated their importance,...