A5027250841- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Smoking Behavior and Cessation
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Inflammation biomarkers and pathways
RMIT University
2022-2024
MIT University
2022
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally and primarily caused by cigarette smoking (CS). Neurocognitive comorbidities such as anxiety cognitive impairments are common among people with COPD. CS-induced lung inflammation oxidative stress may “spill-over” into systemic circulation, driving onset these comorbidities. We investigated whether a prophylactic treatment NADPH Oxidase 2 (NOX2) inhibitor, apocynin, could prevent neurocognitive...
Background and Purpose Cardiovascular disease affects up to half of the patients with chronic obstructive pulmonary (COPD), exerting deleterious impact on health outcomes survivability. Vascular endothelial dysfunction marks onset cardiovascular disease. The present study examined effect a potent NADPH Oxidase (NOX) inhibitor free‐radical scavenger, apocynin, COPD‐related Experimental Approach Male BALB/c mice were exposed either room air (Sham) or cigarette smoke (CS) generated from 9...
Chronic obstructive pulmonary disease (COPD) is a major, incurable respiratory condition that primarily caused by cigarette smoking (CS). Neurocognitive disorders including cognitive dysfunction, anxiety and depression are highly prevalent in people with COPD. It understood increased lung inflammation oxidative stress from CS exposure may 'spill over' into the systemic circulation to promote onset of these extra-pulmonary comorbidities, thus impacts quality life The precise role 'spill-over'...
Background and Purpose: Cardiovascular disease (CVD) affects up to half of the patients with chronic obstructive pulmonary (COPD), which exerts deleterious impact on health outcomes survivability. Vascular endothelial dysfunction marks onset cardiovascular disease. The present study examined effect a potent NADPH Oxidase (NOX) inhibitor free-radical scavenger, apocynin, COPD-related CVD. Experimental Approach: Male BALB/c mice were exposed either room air (Sham) or cigarette smoke (CS)...