A5019410277- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Connexins and lens biology
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Adenosine and Purinergic Signaling
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
Collège de France
2020-2025
Inserm
2020-2025
Centre Interdisciplinaire de Recherche en Biologie
2020-2025
Université Paris Sciences et Lettres
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Sorbonne Université
2020-2024
Max Delbrück Center
2020
Presynaptic glutamate replenishment is fundamental to brain function. In high activity regimes, such as epileptic episodes, this process thought rely on the glutamate-glutamine cycle between neurons and astrocytes. However presence of an astroglial glutamine supply, well its functional relevance in vivo healthy remain controversial, partly due a lack tools that can directly examine transfer. Here, we generated fluorescent probe tracks live cells, which provides direct visual evidence...
Microglial cells are considered as sensors of brain pathology by detecting any sign lesions, infections, or dysfunction and can influence the onset progression neurological diseases. They capable sensing their neuronal environment via many different signaling molecules, such neurotransmitters, neurohormones neuropeptides. The neuropeptide VGF has been associated with metabolic disorders. TLQP21 is a VGF-derived peptide shown to signal C3aR1 C1qBP receptors. effect on microglial functions in...
Astrocytes form extensive networks with diverse calcium activity, yet the organization and connectivity of these across brain regions remain largely unknown. To address this, we developed AstroNet, a data-driven algorithm that uses two-photon imaging to map temporal correlations in astrocyte activation. By organizing individual activation events chronologically, our method reconstructs functional extracts local correlations. We create graph network by tallying direct co-activations between...
Astroglial networks closely interact with neuronal populations, but their functional contribution to representation of sensory information remains unexplored. The superior colliculus (SC) integrates multi-sensory by generating distinct spatial patterns responses specific stimulation. Here, we report that astrocytes from the mouse SC form extensive in retinorecipient layer compared visual cortex. This strong astroglial connectivity relies on high expression gap-junction proteins. Genetic...
Abstract Astrocytes have long been considered to be a largely homogeneous cell population. Recent studies however suggest that astrocytes are highly adapted the local neuronal circuitry. Glucose utilization in retinorecipient superior colliculus (SC) is one of highest brain. Since metabolic support neurons major function astrocytes, they could particular relevance this region and display specific features. However, little known about their interactions with multisensory brain area. We thus...
Abstract Presynaptic glutamate replenishment is fundamental to brain function. In high activity regimes, such as epileptic episodes, this process thought rely on the glutamate-glutamine cycle between neurons and astrocytes. However presence of an astroglial glutamine supply, well its functional relevance in vivo healthy remain controversial, partly due a lack tools that can directly examine transfer. Here, we generated novel fluorescent probe tracks live cells, which provided direct visual...