A5037223625- HIV/AIDS Research and Interventions
- LGBTQ Health, Identity, and Policy
- HIV Research and Treatment
- Sexuality, Behavior, and Technology
- Sex work and related issues
- Lipoproteins and Cardiovascular Health
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Immune Cell Function and Interaction
- Racial and Ethnic Identity Research
- Opioid Use Disorder Treatment
- African Sexualities and LGBTQ+ Issues
- Attachment and Relationship Dynamics
- T-cell and B-cell Immunology
- Food Security and Health in Diverse Populations
- Homelessness and Social Issues
- Reproductive tract infections research
- Cytomegalovirus and herpesvirus research
- Cholesterol and Lipid Metabolism
- Digital Mental Health Interventions
- Syphilis Diagnosis and Treatment
- HIV-related health complications and treatments
- Substance Abuse Treatment and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Whitman-Walker Health
2019-2024
Zero to Three
2022
National Alliance of State and Territorial AIDS Directors
2015
Black and Latina transgender women (BLTW) face significant HIV disparities with estimated prevalence up to 50% annual incidence rates as high 2.8 per 100 person-years. However, few studies have evaluated the acceptability uptake of high-impact prevention interventions among BLTW.Data collection took place in Baltimore, MD Washington, DC from May 2015 2017.This mixed methods study included quantitative interviewer-administered surveys, key informant interviews, focus group discussions. Rapid...
Curing HIV infection will require the elimination of a reservoir infected CD4+ T cells that persists despite HIV-specific cytotoxic cell (CTL) responses. Although viral latency is critical factor in this persistence, recent evidence also suggests role for intrinsic resistance reservoir-harboring to CTL killing. This may have contributed negative outcomes clinical trials, where pharmacologic reversal has thus far failed drive reductions reservoirs. Through transcriptional profiling, we herein...
Abstract The Intact Proviral DNA Assay (IPDA) was developed to address the critical need for a scalable method intact HIV-1 reservoir quantification. This droplet digital PCR-based assay simultaneously targets two regions distinguish genomically proviruses against large background of defective ones, and its application has yielded insights into persistence. Reports failures however, attributed polymorphism, have recently emerged. Here, we describe diverse North American cohort people with...
The Rapid Opioid Dependence Screen (RODS) is an 8-item measure of opioid dependence designed for quick, targeted screening in clinical and research settings. Based on the Diagnostic Statistical Manual Mental Disorders, Fourth edition, criteria, RODS has average administration less than 2 minutes can easily be administered as a stand-alone instrument or part comprehensive interview. This study reports initial validation among sample 97 newly incarcerated, HIV-positive individuals. Using Mini...
Black transgender women are disproportionately affected by violence and poor care-delivery, contributing to mental health. Little is known regarding the effect of gender diverse (TGD) community connection (TCC) on This analysis (a) explores relationships between TCC, polyvictimization, health (b) analyzes how TCC influenced help-seeking following violent experiences among women. Mixed-methods data from 19 were analyzed using correlational thematic content analyses. Findings suggest that...
Background In the United States, transgender women (TW) are disproportionately burdened by HIV infection. Cohort studies needed to evaluate factors driving acquisition among TW over time. These will require implementation strategies that acceptable community and feasible implement. Objective This study aims investigate rate correlates of other health outcomes in eastern southern States. Methods LITE is a multisite prospective cohort 6 US cities, which be followed across 24 months...
Background Black and Latina transgender women (TW) experience a disparate burden of HIV related comorbidities, including poor mental health cardiovascular disease (CVD) risks. Pervasive multilevel stigma discrimination operate as psychosocial stressors for TW living with shape disparities this population. Gender-affirming hormone therapy (GAHT) is commonly used by to facilitate alignment the body gender identity; in context stigma, GAHT may both improve increase CVD Objective This study aims...
Preexposure prophylaxis (PrEP) is effective in preventing HIV among adherent users. However, PrEP uptake transgender women low, and current prescribing guidelines from the Centers for Disease Control Prevention (CDC) are not specific to women. Self-perceived risk of those who PrEP-indicated well understood.This cross-sectional analysis included 1293 screened at baseline March 2018 May 2020 a multisite, prospective cohort study. We compared prevalence indication using CDC criteria versus...
The HIV epidemic disproportionately impacts transgender women in the United States. Cohort studies identify unique risks for affected populations, but use of facility-based methods may bias findings towards individuals living research catchment areas, more engaged health services, or, case those who are open about their identity. Digital clinical trials and other online increasingly common, providing opportunity to reach not commonly research. Simultaneously, there is a need understand...
Antiretroviral (ARV) drug regimens suppress HIV-1 replication but are unable to cure infection. This leaves people living with burdened by a lifelong commitment expensive daily medication. Furthermore, it has become clear that ARV therapy does not fully restore health, leaving individuals at elevated risk for cardiovascular disease, certain types of cancers, and neurocognitive disorders, as well them exposed stigma. Efforts therefore under way develop therapies capable curing A key focus...
Abstract Introduction Transgender women in the United States experience high HIV incidence and suboptimal Pre‐exposure prophylaxis (PrEP) engagement. We sought to estimate PrEP initiation discontinuation rates characterize experiences among a prospective cohort of transgender women. Methods Using sequential, explanatory, mixed‐methods design, 1312 at risk for acquisition were enrolled from March 2018 August 2020 followed through July 2022 (median follow‐up 24 months; interquartile range...
Background: Among communities with elevated HIV burden, increased uptake of PrEP, including long-acting injectable (LAI) could lower incidence. Lack data on LAI PrEP interest among transgender women in the US has limited scientific understanding potential impact new infections within communities. Our objective was to determine percent interested and identify correlates interest. Methods: Transgender enrolled LITE Cohort who completed 12-month surveys between March 2019 September 2021 were...
Abstract Introduction Transgender women (TW) experience an increased risk of human immunodeficiency virus (HIV) acquisition. This study identified patterns HIV awareness and prevention strategies used by TW who were not living with HIV. Methods Data drawn from a baseline survey the LITE Study, multi‐site cohort in Eastern Southern United States (March 2018–August 2020). We conducted latent class analysis to identify classes among reported past 12‐month sexual activity ( N = 958) using 10...
Abstract Background Policy protections for transgender adults in the United States are consistently associated with positive health outcomes. However, studies over-represent non-Latinx White people and obscure variation policies’ intended goals. This study examined racial differences relationship between transgender-related policies women’s self-rated health. Guided by Critical Race Theory, we hypothesized that conferring access to resources (e.g., healthcare) would be better among all...
Opening Paragraph (serves as abstract for submission) and Body The Intact Proviral DNA Assay (IPDA) was developed to address the critical need a precise scalable method intact HIV reservoir quantification 1 . This duplexed droplet digital PCR (ddPCR) assay simultaneously targets Packaging Signal (Ψ) Rev Responsive Element (RRE) within Envelope ( env ) distinguish genomically proviruses against large background of defective ones 2 IPDA requires less time, resources, biological material than...
Home-based (unsupervised) buprenorphine initiation is considered safe and effective, yet many patients report barriers to successful treatment initiation. Prescription digital therapeutics (PDTs) are software-based disease treatments regulated by the US Food Drug Administration (FDA). The reSET-O PDT was authorized FDA in 2018 delivers behavioral for individuals receiving opioid use disorder (OUD). A prototype (PEAR-002b) designed with developed assist unsupervised
Curing HIV infection will require the elimination of a reservoir infected CD4+ T-cells that persists despite HIV-specific CTL responses. While viral latency is critical factor in this persistence, recent evidence also suggests role for intrinsic resistance reservoir-harboring cells to killing. We explored hypothesis mediated by BCL-2 family proteins, which can antagonize CTL-induced apoptosis. show reactivatable disproportionately present BCL-2hi T-cells, are relatively resistant CTL....
<h3>Background</h3> Transgender women (TGW) in the U.S. experience a disproportionate burden of HIV and STIs. National HIV/STI surveillance does not report statistics for TGW. We describe baseline prevalence characteristics STI among cohort TGW enrolled across 6 cities eastern southern US to-date. <h3>Methods</h3> Adult TGW, regardless status, are recruited screening visit. Participants complete socio-behavioral survey, oral screening, urine self-collected anal vaginal specimens <i>Neisseria...
Developing an integrated civilian-military (CIV/MIL) model for healthcare emergency response planning will support collaborative and synchronised medical responses in domestic disasters. Mission accomplishment is achieved by identifying opportunities such integration through initial strategic assessment then developing, piloting, implementing, evaluating disseminating programmes services that meet the documented needs of both civilian military partners. The sectors each have numerous...
<sec> <title>BACKGROUND</title> In the United States, transgender women (TW) are disproportionately burdened by HIV infection. Cohort studies needed to evaluate factors driving acquisition among TW over time. These will require implementation strategies that acceptable community and feasible implement. </sec> <title>OBJECTIVE</title> This study aims investigate rate correlates of other health outcomes in eastern southern States. <title>METHODS</title> LITE is a multisite prospective cohort 6...