A5100444420- Hepatitis B Virus Studies
- Cancer-related gene regulation
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Autophagy in Disease and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Studies
- Cancer-related Molecular Pathways
- Corneal surgery and disorders
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- MRI in cancer diagnosis
- Hepatitis Viruses Studies and Epidemiology
- Traditional Chinese Medicine Analysis
- Liver Disease and Transplantation
Soochow University
2025
Second Affiliated Hospital of Soochow University
2025
Zhejiang University of Technology
2022-2025
Tianjin University of Commerce
2025
Shanghai Medical College of Fudan University
2008-2024
Nanjing Drum Tower Hospital
2024
Kunming University of Science and Technology
2024
Fudan University Shanghai Cancer Center
2009-2024
First Affiliated Hospital of GuangXi Medical University
2019-2024
Guangxi Medical University
2019-2024
The hepatitis B virus (HBV) is a DNA that can cause chronic (CHB) in humans. Current therapies for CHB infection are limited efficacy and do not target the pre-existing viral genomic DNA, which present nucleus as covalently closed circular (cccDNA) form. transcription activator-like (TAL) effector nucleases (TALENs) newly developed enzymes cleave sequence-specific targets. Here, TALENs targeting conserved regions of among different HBV genotypes were constructed. expression Huh7 cells...
Abstract A chemoenzymatic platform for the synthesis of S ‐adenosyl‐ L ‐methionine (SAM) analogues compatible with downstream SAM‐utilizing enzymes is reported. Forty‐four non‐native S/Se‐alkylated Met were synthesized and applied to probing substrate specificity five diverse methionine adenosyltransferases (MATs). Human MAT II was among most permissive MATs analyzed enabled 29 SAM analogues. As a proof concept feasibility natural product “alkylrandomization”, small set...
Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for transcription of viral RNAs, plays key role in persistence. While accumulating evidence suggests that cccDNA is regulated by epigenetic machinery, particularly acetylation cccDNA‐bound histone 3 (H3) and H4, potential contributions methylation related host factors remain obscure. Here, screening series...
Abstract Accumulating evidences indicate that circular RNAs (circRNAs) play a vital role in diverse cancer biology. However, the contributions of circRNAs to hepatocellular carcinoma (HCC) and their underlying mechanism remain largely unknown. The present study aims at investigating circRNA-104718 HCC progression, which has been observed be significantly up-regulated tissues. We found that, higher expression also leds poor prognosis patients. Using luciferase binding assays RNA...
Treatment with exogenous interferon (IFN)-α is not effective in the majority of patients chronic hepatitis B virus (HBV) infection. Recent evidence suggests that HBV has evolved strategies to block nuclear translocation signal transducer and activator transcription (STAT) 1 limit IFN-α-induced cellular antiviral responses. However, it remains unclear whether STAT1 impaired what mechanisms are involved. Here we report expression polymerase (Pol) human hepatic cell lines inhibited induction...
Abstract During hepatitis B virus (HBV) replication, spliced HBV genomes and splice-generated proteins have been widely described, however, their biological clinical significance remains to be defined. Here, an elevation of the proportion variants in sera patients with chronic (CHB) is shown correlate impaired respond interferon-α (IFN-α) therapy. Transfection constructs encoding three most dominant species into cells or ectopic expression two major protein including HBSP...
Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), principal methyl donor in many biological processes. MAT2A up-regulated cancers, including liver cancer and colorectal (CRC) a potentially important drug target. We developed family fluorinated N,N-dialkylaminostilbene agents, called FIDAS that inhibit proliferation CRC cells vitro vivo. Using biotinylated analogue, we identified as direct exclusive binding target these agents....
Abstract A chemoenzymatic platform for the synthesis of S ‐adenosyl‐ L ‐methionine (SAM) analogues compatible with downstream SAM‐utilizing enzymes is reported. Forty‐four non‐native S/Se‐alkylated Met were synthesized and applied to probing substrate specificity five diverse methionine adenosyltransferases (MATs). Human MAT II was among most permissive MATs analyzed enabled 29 SAM analogues. As a proof concept feasibility natural product “alkylrandomization”, small set...
Centenarians (CENs) are excellent subjects to study the mechanisms of human longevity and healthy aging. Here, we analyzed transcriptomes 76 centenarians, 54 centenarian-children, 41 spouses centenarian-children by RNA sequencing found that, among significantly differentially expressed genes (SDEGs) exhibited CENs, autophagy-lysosomal pathway is up-regulated. Overexpression several from this pathway, CTSB , ATP6V0C ATG4D WIPI1 could promote autophagy delay senescence in cultured IMR-90...
3514 Background: Despite the fundamental role of WNT signaling in GI cancers, especially colorectal cancer (CRC), no drug targeting has been successfully developed. CGX1321, a highly-potent and selective inhibitor O-acyltransferase Porcupine, blocks ligand secretion. Preclinical studies show that CGX1321 inhibits growth tumors with RSPO fusions or inactivating RNF43 mutations. Activation associated immune-suppression resistance to immunotherapy. Methods: The first-in-human trials...
Four-week treatment of linvencorvir (RO7049389) was generally safe and well tolerated, showed anti-viral activity in chronic hepatitis B (CHB) patients. This study evaluated the efficacy, safety, pharmacokinetics 48-week with plus standard care (SoC) CHB
Abstract Background The aim of this study is to investigate the prevalence myopia and high associated risk factors in key schools Xi'an, China. Methods This cross-sectional started September 2021 was conducted for one month. A total 11,011 students from 10 primary schools, five junior Xi'an were randomly selected undergo visual acuity measurement non-cycloplegic autorefraction. questionnaire completed by their parents together. Results 75.7% 9.7%, respectively. rose significantly as grade or...
Either oxaliplatin- or irinotecan-containing regimen could receive a good effectiveness in patients with metastatic colorectal cancer as the first-line chemotherapy, but not all would benefit from treatment they have received. This study was to investigate role of single nucleotide polymorphisms (SNPs) methylenetetrahydrofolate reductase (MTHFR) and ATP-binding cassette sub-family G member 2 (ABCG2) selecting most appropriate for individual patients. Ninety-two treated 5-fluoropyrimidine...
Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark colorectal cancers (CRC). As part program to develop epigenetic regulators for cancer therapy, we developed carboxamide-substituted benzhydryl amines (CBAs) bearing aryl heteroaryl groups that selectively targeted histone lysine demethylases (KDMs) and functioned as inhibitors the pathway. A biotinylated variant N-((5-chloro-8-hydroxyquinolin-7-yl)...
To compare the results between type I tympanoplasty performed with transcanal endoscopic ear surgery (TEES) and microscopic (MES) for treatment of chronic otitis media in a homogenous group patients.A retrospective study was our department January 2011 2016 to review primary cases subtotal perforation, an intact ossicular chain, dry at least 1 month, normal middle mucosa, follow-up period 6 months post surgery. The adoption TEES or MES divided temporally (before since 2013). undertaken 224...
The outer membrane protein (OMP) is a kind of biofilm matrix component that widely exists in Gram-negative bacteria. However, the mechanism OMP involved settlement molluscs still unclear. In this study, mussel Mytilus coruscus was selected as model to explore function ompR, two-component system response regulator, on Pseudoalteromonas marina biofilm-forming capacity and settlement. motility ΔompR strain increased, decreased, inducing activity biofilms plantigrades decreased significantly (p...
Gastric cancer is a prevalent malignancy worldwide, with early detection and treatment being vital to improving patient outcomes. Amino acids (AAs), as essential regulators in cell metabolism, are implicated the progression response treatment. This study aimed investigate dynamics of plasma AA levels gastric patients preoperatively, postoperatively, following nutritional intervention, comparing them healthy controls. We analyzed 22 AAs samples from 66 55 individuals. The results show that...
Human cytomegalovirus (HCMV) infection is linked to the development and severity of cardiovascular disease atherosclerosis; however, there little known about promotion atherosclerosis. miR-US25-1 one HCMV-encoded miRNAs targets cellular genes that are essential for virus growth control life cycle host cells. The prominent regulation on cell attracts us explore its role in atherosclerosis promotion. It was indicated level upregulated subjects or endothelial cells with HCMV infection;...
Abstract Multi-layered mechanisms of virus host interaction exist for chronic hepatitis B (HBV) infection, which have been typically manifested at the microRNA level. Our previous study suggested that miRNA-939 (miR-939) may play a potential role in regulating HBV replication. Here we further investigated mechanism by miR-939 regulates life cycle. We found inhibited abundance viral RNAs without direct miRNA-mRNA base pairing, but via factors. Expression profiling and functional validation...
Given the high incidence and mortality rates of colorectal cancer (CRC) inadequacy existing treatments for many patients, this study aimed to explore potential Capping Actin Protein (CAPG), a protein involved in actin-related movements, as novel therapeutic target CRC.Bioinformatic analysis gene expression was conducted using UALCAN website. Cell proliferation measured CCK-8 kit. cycle, apoptosis, ferroptosis were analyzed flow cytometry. Tumorigenesis evaluated by subcutaneous inoculation...