A5002656582- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Nonmelanoma Skin Cancer Studies
- Cervical Cancer and HPV Research
- Porphyrin and Phthalocyanine Chemistry
- Nail Diseases and Treatments
- Insect Pest Control Strategies
- Mosquito-borne diseases and control
- Curcumin's Biomedical Applications
- Electrospun Nanofibers in Biomedical Applications
- Photoacoustic and Ultrasonic Imaging
- Infectious Diseases and Mycology
- Fungal Infections and Studies
- Essential Oils and Antimicrobial Activity
- Cutaneous lymphoproliferative disorders research
- Wound Healing and Treatments
- biodegradable polymer synthesis and properties
- Phytochemistry Medicinal Plant Applications
- Ocular Infections and Treatments
- Skin Protection and Aging
- Advanced Cellulose Research Studies
- Trypanosoma species research and implications
- bioluminescence and chemiluminescence research
- Advanced Nanomaterials in Catalysis
- Bee Products Chemical Analysis
Universidade de São Paulo
2016-2025
Universidade Federal de São Carlos
2016-2025
Texas A&M University
2025
Hospital Universitário da Universidade de São Paulo
2019
Universidade Estadual de Campinas (UNICAMP)
2005-2018
Hospital Amaral Carvalho
2016
Instituto de Psicologia Comportamental de São Carlos
2015
Hospital Vozandes
2015
Universidade de Caxias do Sul
2015
National Polytechnic School
2015
Blend solutions of poly(ε-caprolactone) (PCL) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh) were successfully electrospun. The weight ratio PCL/QCh ranged in the interval 95/5-70/30 while two QCh samples used, namely QCh1 (DQ¯ = 47.3%; DPv¯ 2218) QCh2 71.1%; 1427). According to characteristics derivative content on resulting nonwoven, nanofibers displayed different average diameter (175 nm-415 nm), nonwovens exhibited variable porosity (57.0%-81.6%), swelling capacity...
Graphene Oxide (GO) with their interesting properties including thermal and electrical conductivity antibacterial characteristics have many promising applications in medicine. The prevalence of resistant bacteria is considered a public health problem worldwide, herein, GO has been used as broad spectrum selective agent based on the PTT / PDT effect. preparation, characterization, determination photophysical two different sizes graphene oxide described. In vitro light dose...
Graphical Abstract Brief description of the procedures carried out in this study. In vivo and vitro antibacterial photodynamic therapy (aPDT) studies, where aPDT mediated by C-DOTS blue LED light against S. aureus was evaluated.
Gram-negative bacteria and in biofilms are very difficult to eradicate the most antibiotic-resistant bacteria. Therapeutic alternatives less susceptible mechanisms of resistance urgently needed respond an alarming increase resistant nosocomial infections. Antibacterial photodynamic inactivation (PDI) generates oxidative stress that triggers multiple cell death more counteract by We explore PDI multidrug-resistant bacterial strains collected from patients show how positive charge distribution...
Core-sheath nanofibers were successfully prepared via coaxial electrospinning by using chitosan with well-defined structural characteristics as the shell layer and poly (vinyl alcohol) (PVA) containing tetracycline hydrochloride (TH) core layer. The effects of average degree deacetylation (DD‾) post-electrospinning genipin crosslinking on physicochemical biological properties resulting nonwovens evaluated. Defect-free geometrically uniform diameters predominantly in range 100-300 nm...
This work evaluated antimicrobial photodynamic therapy (PDT), sonodynamic (SDT), and the association of both therapies (sonophotodynamic [SPDT]), mediated by curcumin (Cur) against Staphylococcus aureus biofilm. Next, additional strategies for these treatments were assessed.S. biofilms received PDT, SDT, SPDT, Cur (80 µM), LED light (450 nm), 1 MHz ultrasound. The same also performed adding a strategy: with sodium dodecyl sulfate (SDS), potassium iodide (KI) or pre-treatment Cell viability...
Therapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2) multifunctional therapeutic dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC were characterized distinct physicochemical...
Abstract Infectious pneumonia is a major cause of morbidity/mortality, mainly because the increasing rate microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) emerging as promising approach, effects are based on oxidative stress, preventing microorganism resistance. In two previous studies, in vitro inactivation Streptococcus pneumoniae using indocyanine green (ICG) and infrared light source was success killing 5 log 10 colony‐forming units (CFU/mL) with only μ mol/L ICG. this...
(1) Background: Cervical cancer is the third most commonly diagnosed and fourth leading cause of death in women worldwide. The highest incidence rates are Africa, followed by South-Central Asia South America. According to Brazilian National Institute Cancer (INCA), 16,370 new cases cervical were estimated for each year biennium 2018-2019. About 90% cancers originate from malignant progression intraepithelial neoplasia (CIN) which classified based on cytohistological characteristics (low-...
Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility ability to incorporate great variety of active agents. Silver sulfadiazine (SDZ) an antibiotic used control bacterial infection in external wounds. Aiming combine the properties PLA SDZ, hydrotalcite ([Mg–Al]‐LDH) was as host matrix obtain antimicrobial system efficient delivering SDZ from electrospun scaffolds intended for wound skin healing. The structural reconstruction method...
Significance Hospital-acquired infections also caused by multidrug-resistant bacteria are currently one of the most severe problems that our society faces, which constitute an excellent risk for humankind. The absence alternatives to combat these types leaves humanity highly vulnerable. Therefore, it becomes imperative develop new technologies fight bacterial infections, with alternative mechanisms action relative classical antibiotics. Since ventilator-associated pneumonia (VAP) occurs in...
The epimastigote stage of Trypanosoma cruzi undergoes PCD (programmed cell death) when exposed to FHS (fresh human serum). Although it has been known for over 30 years that complement is responsible FHS-induced death, the link between activation and triggering not established. We have previously shown mitochondrion participates in orchestration this model. Several changes mitochondrial function were described, particular was mitochondrion-derived O(2)(*-) (superoxide radical) necessary PCD....
This study reports a new class of photocatalytic hybrid clay nanocomposites prepared from low-cost sources (kaolinite and Carica papaya seeds) doped with Zn Cu salts via solvothermal process. X-ray diffraction analysis suggests that Cu-doping Cu/Zn-doping introduce phases into the crystalline structure Kaolinite clay, which is linked to reduced band gap kaolinite typically between 4.9 8.2 eV 2.69 for Cu-doped 1.5 Cu/Zn (Nisar, J.; Århammar, C.; Jämstorp, E.; Ahuja, R. Phys. Rev. B 2011, 84,...
Photonic crystals are some of the more spectacular realizations that periodic arrays can change behavior electromagnetic waves. In nature, so-called structural colors appear in insects and even plants. Some species create beautiful color patterns as part biological such reproduction or defense mechanisms a form biomimetics. The interaction between light matter occurs at surface, producing diffraction, interference reflectance, transmission is possible under suitable conditions. particular,...
Cancer is the second leading cause of death globally and responsible, where about 1 in 6 deaths world. Therefore, there a need to develop effective antitumor agents that are targeted only specific site tumor improve efficiency cancer diagnosis treatment and, consequently, limit unwanted systemic side effects currently obtained by use chemotherapeutic agents. In this context, due its unique physical chemical properties graphene oxide (GO), it has attracted interest biomedicine for therapy.