A5077935688- Infant Nutrition and Health
- Birth, Development, and Health
- Apelin-related biomedical research
- Breastfeeding Practices and Influences
- Digestive system and related health
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Infant Health and Development
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Probiotics and Fermented Foods
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
- Nuclear Receptors and Signaling
- Child Nutrition and Water Access
- Neuroscience of respiration and sleep
- Autoimmune and Inflammatory Disorders Research
- Clinical Nutrition and Gastroenterology
- Fatty Acid Research and Health
- Cannabis and Cannabinoid Research
- Regulation of Appetite and Obesity
- Viral gastroenteritis research and epidemiology
Lille Inflammation Research International Center
2021-2025
Inserm
2022-2025
Université de Lille
2017-2025
Centre Hospitalier Universitaire de Lille
2018-2025
Institute for Translational Research in Inflammation
2021-2025
Infinitesimal (United States)
2023
According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity accelerated growth in neonates predispose offspring white adipose tissue (WAT) accumulation. In rodents, adipogenesis mainly develops during lactation. The mechanisms underlying phenomenon known as developmental programming remain elusive. We previously reported that adult rat from high-fat diet-fed dams (called HF) exhibited hypertrophic adipocyte, hyperleptinemia increased leptin mRNA levels a...
Introduction The microbiological safety of donor milk (DM) is commonly ensured by holder pasteurization (HoP, 62.5°C for 30 min) in human banks despite its detrimental effects on several bioactive factors. We compared the concentration twelve endocannabinoid (eCB)-like mediators raw DM and after or high hydrostatic pressure processing (HHP, 350 MPa at 38°C), a non-thermal substitute pasteurization. Methods measured five N-acyl-ethanolamines (NAEs) seven 2-mono-acyl-glycerols (2-MAGs) raw-DM,...
Human milk oligosaccharides (HMOs) promote the development of infant gut microbiota, notably through growth beneficial bacteria.
According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity accelerated growth in neonates program later life. White adipose tissue (WAT) has been focus developmental programming events, although underlying mechanisms remain elusive. In rodents, WAT development primarily occurs during lactation. We previously reported that adult rat offspring from dams fed a high-fat (HF) diet exhibited fat accumulation decreased peroxisome proliferator-activated receptor γ...
The milk metabolome is composed of hundreds molecules that can impact infant development. In preterm infants, sterilized donor (DM) frequently used for their feeding. We aimed to identify differences in the DM after two types sterilization: Holder pasteurization (HoP) and a high hydrostatic pressure (HP) processing. samples were by HoP (62.5°C 30 min) or processed HP (350 MPa at 38°C). 595 metabolites analyzed using an untargeted metabolomic analysis. Both treatments differentially altered...
Human milk banks (HMBs) provide sterilized donor (DM) for the feeding of preterm infants. Most HMBs use standard method Holder pasteurization (HoP) performed by heating DM at 62.5 °C 30 min. High hydrostatic pressure (HHP) processing has been proposed as an alternative to HoP. This study aims evaluate intestinal barrier integrity and microbiota composition in adult mice subjected a chronic oral administration HoP- or HHP-DM. Mice were treated daily gavages with HHP-DM over seven days....
Preterm infants are highly susceptible to oxidative stress due an imbalance between endogenous oxidant and antioxidant systems. In addition, these newborns frequently fed with donor milk (DM) treated by Holder pasteurization (HoP) at 62.5 °C for 30 min, which is known alter numerous heat-sensitive factors, including some antioxidants. High hydrostatic pressure (HHP) processing was recently proposed as innovative method the treatment of DM. The present study aimed measure redox balance HoP-...
An inadequate perinatal nutritional environment can alter the maturation of intestinal barrier and promote long-term pathologies such as metabolic syndrome or chronic diseases. The microbiota seems to play a determining role in development barrier. In present study, we investigated impact consuming an early postnatal prebiotic fiber (PF) on growth, morphology at weaning postnatal-growth-restricted mice (PNGR).Large litters (15 pups/mother) were generated from FVB/NRj induce PNGR day 4 (PN4)...
Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring metabolic pathologies such as obesity. Using a model 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone male rat displayed hyperleptinemia with modifications leptin receptor messenger RNA (mRNA) levels white adipose tissue (WAT). Apelin is member adipokine family regulates various aspects...
Sterilized donor milk (DM) is frequently used for feeding preterm infants. To date, the effect of different modes DM sterilization on short-chain fatty acids (SCFAs) remains unknown. We aimed to quantify SCFAs in samples after two types sterilization: Holder pasteurization (HoP) and a high hydrostatic pressure (HP) processing. Eight pooled were sterilized by HoP (62.5°C 30 min) or processed HP (350 MPa at 38°C). Raw was as control. Six quantified gas chromatography/mass spectrometry....
High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the sterilization of human breast milk (BM). HHP preserves numerous bioactive factors that are degraded by HoP, but no data available apelin and glucagon-like peptide 1 (GLP-1), two hormones implicated in control glucose metabolism directly via gut-brain axis. This study aims determine effects HoP on GLP-1 concentrations BM test effect oral treatments with HoP-...
Pasteurized human donor milk (DM) is frequently used for feeding preterm newborns and extrauterine growth-restricted (EUGR) infants. Most banks performed a pasteurization of DM using the standard method Holder (HoP) which consists heating at 62.5°C 30 min. High hydrostatic pressure (HHP) processing was proposed to be an innovative nonthermal pasteurize DM. However, effect different modes on body growth, intestinal maturation, microbiota has never been investigated in vivo during lactation....
The microbiological safety of donor milk (DM) is widely ensured by Holder pasteurization (HoP, 62.5°C for 30 min) in human banks (HMBs) despite its detrimental effects on intrinsic bio-active factors. We aimed to compare the antimicrobial properties DM after HoP treatment or High Hydro-static Pressure processing (HHP, 350 MPa at 38°C), a non-thermal substitute sterilization. To this end, we assessed lactoferrin and lysozyme concentrations raw, HHP- HoP-treated pools (n=8). impact both...