Tong Chen

ORCID: 0000-0003-1951-0257
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About
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Research Areas
  • Pain Mechanisms and Treatments
  • Cancer Treatment and Pharmacology
  • Potassium and Related Disorders
  • Pharmacological Effects and Toxicity Studies
  • Glaucoma and retinal disorders
  • Nanoparticle-Based Drug Delivery
  • Peroxisome Proliferator-Activated Receptors
  • Ocular Surface and Contact Lens
  • Neurological diseases and metabolism
  • Medical Research and Treatments
  • Ion Transport and Channel Regulation
  • Radiomics and Machine Learning in Medical Imaging
  • Parkinson's Disease Mechanisms and Treatments
  • Advanced X-ray and CT Imaging
  • Drug Transport and Resistance Mechanisms
  • Cardiac Imaging and Diagnostics
  • Cell Adhesion Molecules Research
  • HIV/AIDS drug development and treatment
  • Proteoglycans and glycosaminoglycans research
  • Nanoplatforms for cancer theranostics
  • Income, Poverty, and Inequality
  • Regional Development and Environment
  • Epilepsy research and treatment
  • Anesthesia and Pain Management

Xuzhou Central Hospital
2025

Kunming Medical University
2015-2024

Chinese People's Liberation Army
2023

Background The Triglyceride-Glucose (TyG) index has become a reliable indicator for evaluating the level of insulin resistance, pivotal factor in both metabolic and neurodegenerative disorders. Serum neurofilament light chain (sNfL) serves as responsive biomarker detecting neuroaxonal injury. Despite this, interplay between TyG sNfL levels not been sufficiently investigated. aim this research is to scrutinize correlation across substantial, population-based cohort. Methods Our study involved...

10.1371/journal.pone.0321226 article EN cc-by PLoS ONE 2025-04-10

To investigate the predictive value of radiomics features based on cardiac magnetic resonance (CMR) cine images for left ventricular adverse remodeling (LVAR) after acute ST-segment elevation myocardial infarction (STEMI).We conducted a retrospective, single-center, cohort study involving 244 patients (random-split into 170 and 74 training testing, respectively) having an STEMI (88.5% males, 57.0 ± 10.3 years age) who underwent CMR examination at one week six months percutaneous coronary...

10.3348/kjr.2023.0061 article EN Korean Journal of Radiology 2023-01-01

Background: The aim of this study was to investigate the factors affecting plasma valproic acid (VPA) concentration in pediatric patients with epilepsy and clinical significance CYP2C9 gene polymorphisms personalized dosing using therapeutic drug monitoring pharmacogenetic testing. Methods: medical records children who underwent at our institution between July 2022 2023 met inclusion criteria were reviewed. Statistical analysis performed determine whether age, sex, blood ammonia, liver...

10.1097/ftd.0000000000001180 article EN Therapeutic Drug Monitoring 2024-01-26

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition affecting cancer patients, often resulting from the use of neurotoxic agents, such as paclitaxel. This study aimed to establish rat model CIPN through systemic administration paclitaxel and identify potential biomarkers using activity-based protein profiling (ABPP) with desthiobiotin iodoacetamide (DBIA) probe. Male Sprague-Dawley rats received injections at dosage 2 mg/kg on Days 0, 2, 4, 6. Behavioral...

10.1101/2024.10.30.620562 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-11-01

10.16418/j.issn.1000-3045.20201007003 article EN Bulletin of Chinese Academy of Sciences (Chinese Version) 2020-01-01
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